| REGNREGENERON PHARMACEUTICALS, INC. | 2,722,071 | $2.10B |
| GILDGILEAD SCIENCES, INC. | 3,484,026 | $485.6M |
| INSMINSMED Inc | 2,617,251 | $428.0M |
| JAZZJazz Pharmaceuticals plc | 1,958,940 | $370.3M |
| SNYSanofi | 7,165,193 | $345.2M |
| BBIOBridgeBio Pharma, Inc. | 2,438,925 | $181.1M |
| ARGXARGENX SE | 233,493 | $170.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 470,390 | $155.6M |
| TERNTerns Pharmaceuticals, Inc. | 2,409,019 | $127.0M |
| IONSIONIS PHARMACEUTICALS INC | 1,575,023 | $118.3M |
| LGNDLigand Pharmaceuticals Incorporated | 573,177 | $114.4M |
| RVMDREVOLUTION MEDICINES, INC. | 1,133,546 | $110.2M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 968,182 | $81.2M |
| PTCTPTC THERAPEUTICS, INC. | 1,121,388 | $76.4M |
| AXSMAxsome Therapeutics, Inc. | 438,490 | $74.1M |
| EXELEXELIXIS, INC. | 1,663,917 | $71.4M |
| INCYIncyte Corp. | 693,785 | $65.3M |
| ONCBeOne Medicines Ltd. | 201,641 | $59.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 626,845 | $54.5M |
| ARQTArcutis Biotherapeutics, Inc. | 2,297,943 | $54.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 933,879 | $52.8M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 942,429 | $52.0M |
| ORKAOruka Therapeutics, Inc. | 1,004,056 | $49.2M |
| NUVLNuvalent, Inc. | 434,742 | $44.5M |
| SYRESpyre Therapeutics, Inc. | 882,833 | $44.5M |
| ABVXAbivax SA | 382,830 | $42.6M |
| RDYDR REDDYS LABORATORIES LTD | 2,856,094 | $39.6M |
| APGEApogee Therapeutics, Inc. | 405,538 | $34.1M |
| BCAXBicara Therapeutics Inc. | 1,621,643 | $32.3M |
| GMABGenmab A/S | 1,193,145 | $32.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 462,707 | $29.0M |
| SLNOSOLENO THERAPEUTICS INC | 835,178 | $28.0M |
| PCVXVaxcyte, Inc. | 473,363 | $27.5M |
| CNTACentessa Pharmaceuticals plc | 684,482 | $27.2M |
| TNGXTango Therapeutics, Inc. | 1,296,283 | $27.1M |
| CYTKCYTOKINETICS INC | 409,784 | $27.0M |
| SPRYARS Pharmaceuticals, Inc. | 3,278,549 | $26.3M |
| GPCRStructure Therapeutics Inc. | 531,595 | $25.6M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 770,160 | $24.7M |
| TEVATeva Pharmaceutical Industries Limited | 732,290 | $22.1M |
| ADMAADMA BIOLOGICS, INC. | 2,344,899 | $21.1M |
| ORICOric Pharmaceuticals, Inc. | 1,452,835 | $18.4M |
| OLMAOlema Pharmaceuticals, Inc. | 1,218,957 | $18.2M |
| SLDBSolid Biosciences Inc. | 2,192,937 | $15.8M |
| PTGXProtagonist Therapeutics, Inc | 137,871 | $14.5M |
| IVAInventiva S.A. | 2,461,565 | $13.7M |
| MANEVeradermics Incorporated | 200,000 | $12.6M |
| PGENPRECIGEN, INC. | 2,633,780 | $10.2M |
| LENZLENZ Therapeutics, Inc. | 1,100,148 | $10.1M |
| CNTXContext Therapeutics Inc. | 3,803,338 | $10.0M |
| IMMXImmix Biopharma, Inc. | 969,066 | $8.8M |
| QUREuniQure N.V. | 480,866 | $7.9M |
| SIONSionna Therapeutics, Inc. | 175,483 | $7.0M |
| INVAInnoviva, Inc. | 257,607 | $6.0M |
| ACADACADIA PHARMACEUTICALS INC | 230,072 | $5.1M |
| STOKStoke Therapeutics, Inc. | 142,793 | $4.6M |
| BIOABioAge Labs, Inc. | 265,373 | $4.6M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 85,956 | $4.4M |
| ACETAdicet Bio, Inc. | 626,571 | $4.3M |
| IBRXImmunityBio, Inc. | 491,093 | $3.8M |
| TVTXTravere Therapeutics, Inc. | 124,192 | $3.7M |
| ANABANAPTYSBIO, INC | 65,820 | $3.7M |
| TGTXTG THERAPEUTICS, INC. | 84,280 | $2.8M |
| ADPTAdaptive Biotechnologies Corp | 174,330 | $2.4M |
| ARVNARVINAS, INC. | 216,788 | $2.3M |
| ROIVRoivant Sciences Ltd. | 80,032 | $2.2M |
| CRDFCardiff Oncology, Inc. | 1,205,803 | $2.0M |
| ZYMEZymeworks Inc. | 77,659 | $1.9M |
| FOLDAMICUS THERAPEUTICS, INC. | 129,278 | $1.9M |
| MAZEMaze Therapeutics, Inc. | 59,637 | $1.8M |
| OGNOrganon & Co. | 282,913 | $1.7M |
| VCELVericel Corp | 45,675 | $1.5M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 215,391 | $1.4M |
| INABIN8BIO, INC. | 914,531 | $1.4M |
| SRRKScholar Rock Holding Corp | 26,882 | $1.3M |
| ANIPANI PHARMACEUTICALS INC | 16,018 | $1.2M |
| MRNAModerna, Inc. | 22,527 | $1.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 52,623 | $1.1M |
| KODKodiak Sciences Inc. | 29,348 | $1.1M |
| ARDXARDELYX, INC. | 185,250 | $1.1M |
| COGTCogent Biosciences, Inc. | 24,353 | $937K |
| DNLIDenali Therapeutics Inc. | 48,732 | $936K |
| ELVNEnliven Therapeutics, Inc. | 20,182 | $791K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 24,073 | $732K |
| HROWHARROW, INC. | 20,631 | $727K |
| VKTXViking Therapeutics, Inc. | 20,255 | $659K |
| PVLAPALVELLA THERAPEUTICS, INC. | 4,657 | $580K |
| BEAMBeam Therapeutics Inc. | 23,487 | $560K |
| NUVBNuvation Bio Inc. | 118,593 | $509K |
| XERSXeris Biopharma Holdings, Inc. | 80,217 | $465K |
| APLSApellis Pharmaceuticals, Inc. | 11,380 | $458K |
| CMPXCompass Therapeutics, Inc. | 66,607 | $352K |
| ESPREsperion Therapeutics, Inc. | 126,374 | $346K |
| ZVRAZEVRA THERAPEUTICS, INC. | 36,794 | $343K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 8,287 | $280K |
| KROSKeros Therapeutics, Inc. | 21,756 | $240K |
| KNSAKiniksa Pharmaceuticals International, plc | 4,944 | $238K |
| SIGASIGA TECHNOLOGIES INC | 43,862 | $235K |
| AVXLANAVEX LIFE SCIENCES CORP. | 71,908 | $221K |
| FLGTFulgent Genetics Inc. | 13,777 | $219K |
| BHVNBiohaven Ltd. | 20,506 | $173K |
| SANASana Biotechnology, Inc. | 57,909 | $167K |
| GRFSGrifols S.A. | 19,611 | $157K |
| RGNXREGENXBIO Inc. | 16,801 | $141K |
| TRDAEntrada Therapeutics, Inc. | 11,102 | $140K |
| UPBUpstream Bio, Inc. | 14,589 | $131K |
| KURAKura Oncology, Inc. | 14,353 | $117K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 37,916 | $116K |
| CNTNCanton Strategic Holdings, Inc. | 25,000 | $82K |
| ONCYONCOLYTICS BIOTECH INC | 69,842 | $71K |
| GERNGERON CORP | 30,761 | $46K |
| RCKTRocket Pharmaceuticals Inc. | 11,095 | $40K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 11,283 | $40K |