| SNYSanofi | 4,754,359 | $229.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 687,816 | $227.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 254,946 | $197.0M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 1,286,303 | $111.9M |
| GILDGILEAD SCIENCES, INC. | 797,709 | $111.2M |
| MRNAModerna, Inc. | 1,977,079 | $100.4M |
| INSMINSMED Inc | 538,257 | $88.0M |
| CNTACentessa Pharmaceuticals plc | 2,049,439 | $81.4M |
| ARGXARGENX SE | 95,253 | $69.6M |
| ZBIOZenas BioPharma, Inc. | 3,127,031 | $61.1M |
| PVLAPALVELLA THERAPEUTICS, INC. | 433,015 | $54.0M |
| INCYIncyte Corp. | 499,864 | $47.0M |
| CYTKCYTOKINETICS INC | 699,453 | $46.1M |
| FBRXForte Biosciences, Inc. | 1,765,516 | $45.7M |
| BBIOBridgeBio Pharma, Inc. | 588,434 | $43.7M |
| RZLTRezolute, Inc. | 12,990,659 | $39.6M |
| SRRKScholar Rock Holding Corp | 797,913 | $39.2M |
| EXELEXELIXIS, INC. | 912,913 | $39.2M |
| APGEApogee Therapeutics, Inc. | 442,738 | $37.3M |
| GMABGenmab A/S | 1,251,590 | $33.6M |
| PCVXVaxcyte, Inc. | 566,828 | $32.9M |
| ARQTArcutis Biotherapeutics, Inc. | 1,077,267 | $25.4M |
| ANABANAPTYSBIO, INC | 364,121 | $20.2M |
| VCELVericel Corp | 627,515 | $20.2M |
| AXSMAxsome Therapeutics, Inc. | 108,571 | $18.4M |
| AGMBAgomAb Therapeutics NV | 1,618,000 | $17.0M |
| LQDALiquidia Corp | 438,767 | $16.6M |
| PTCTPTC THERAPEUTICS, INC. | 225,916 | $15.4M |
| ADMAADMA BIOLOGICS, INC. | 1,701,315 | $15.3M |
| FDMT4D Molecular Therapeutics, Inc. | 1,432,260 | $13.3M |
| VRDNViridian Therapeutics, Inc.\DE | 668,968 | $13.1M |
| AQSTAquestive Therapeutics, Inc. | 2,940,339 | $12.2M |
| ARVNARVINAS, INC. | 1,140,715 | $12.1M |
| ABVXAbivax SA | 108,200 | $12.0M |
| COGTCogent Biosciences, Inc. | 285,661 | $11.0M |
| IBRXImmunityBio, Inc. | 1,386,591 | $10.6M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 1,059,849 | $10.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 169,014 | $9.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 162,097 | $9.2M |
| UPBUpstream Bio, Inc. | 979,758 | $8.8M |
| KODKodiak Sciences Inc. | 210,210 | $8.0M |
| OVIDOvid Therapeutics Inc. | 3,571,000 | $7.9M |
| KROSKeros Therapeutics, Inc. | 689,229 | $7.6M |
| XERSXeris Biopharma Holdings, Inc. | 856,813 | $5.0M |
| NTLAIntellia Therapeutics, Inc. | 368,617 | $4.7M |
| ZYMEZymeworks Inc. | 182,410 | $4.6M |
| JAZZJazz Pharmaceuticals plc | 19,667 | $3.7M |
| RCKTRocket Pharmaceuticals Inc. | 1,023,747 | $3.7M |
| TVTXTravere Therapeutics, Inc. | 92,812 | $2.8M |
| ANIPANI PHARMACEUTICALS INC | 22,985 | $1.8M |
| AVXLANAVEX LIFE SCIENCES CORP. | 532,252 | $1.6M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 237,715 | $1.5M |
| CATXPerspective Therapeutics, Inc. | 222,142 | $926K |
| TGTXTG THERAPEUTICS, INC. | 27,590 | $917K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 14,112 | $885K |
| ROIVRoivant Sciences Ltd. | 31,287 | $867K |
| FLGTFulgent Genetics Inc. | 49,207 | $782K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 18,904 | $525K |
| HROWHARROW, INC. | 12,255 | $432K |
| ZVRAZEVRA THERAPEUTICS, INC. | 42,195 | $393K |
| LRMRLarimar Therapeutics, Inc. | 61,350 | $276K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 5,059 | $261K |
| OLMAOlema Pharmaceuticals, Inc. | 14,086 | $210K |
| FLNAFilana Therapeutics Inc. | 115,097 | $195K |
| ZNTLZentalis Pharmaceuticals, Inc. | 65,520 | $153K |
| SIGASIGA TECHNOLOGIES INC | 28,422 | $152K |
| LBRXLB PHARMACEUTICALS INC | 5,000 | $123K |
| PTGXProtagonist Therapeutics, Inc | 1,001 | $106K |
| PLRXPLIANT THERAPEUTICS, INC. | 62,651 | $79K |
| ACADACADIA PHARMACEUTICALS INC | 3,510 | $78K |
| KALVKalVista Pharmaceuticals, Inc. | 3,719 | $75K |
| KURAKura Oncology, Inc. | 8,172 | $66K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 12,222 | $43K |
| TERNTerns Pharmaceuticals, Inc. | 719 | $38K |
| MAZEMaze Therapeutics, Inc. | 1,097 | $33K |
| RCUSArcus Biosciences, Inc. | 1,410 | $30K |
| ANTXAN2 Therapeutics, Inc. | 8,322 | $28K |
| FOLDAMICUS THERAPEUTICS, INC. | 1,460 | $21K |
| FENCFENNEC PHARMACEUTICALS INC. | 2,401 | $15K |
| BDTXBlack Diamond Therapeutics, Inc. | 5,363 | $11K |
| BMEABiomea Fusion, Inc. | 6,969 | $11K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 1,013 | $10K |
| TNGXTango Therapeutics, Inc. | 354 | $7K |
| CGEMCullinan Therapeutics, Inc. | 516 | $7K |
| CHRSCoherus Oncology, Inc. | 3,916 | $7K |
| ALDXAldeyra Therapeutics, Inc. | 2,962 | $5K |
| CCCCC4 Therapeutics, Inc. | 1,878 | $5K |
| ANNXAnnexon, Inc. | 753 | $4K |
| AARDAardvark Therapeutics, Inc. | 1,083 | $4K |
| SGMTSagimet Biosciences Inc. | 781 | $4K |
| DFTXDefinium Therapeutics Inc. | 207 | $4K |
| CRDFCardiff Oncology, Inc. | 2,253 | $4K |
| FATEFATE THERAPEUTICS INC | 3,015 | $4K |
| JSPRJasper Therapeutics Inc. | 3,868 | $3K |
| ATNMActinium Pharmaceuticals, Inc. | 1,403 | $1K |
| ORGOOrganogenesis Holdings Inc. | 374 | $886 |
| SRZNSurrozen Inc. | 29 | $845 |
| SKYESkye Bioscience, Inc. | 1,158 | $712 |
| AGIOAGIOS PHARMACEUTICALS, INC. | 19 | $643 |
| BEAMBeam Therapeutics Inc. | 24 | $572 |
| KLRSKalaris Therapeutics, Inc. | 34 | $196 |
| OGNOrganon & Co. | 4 | $24 |