| LLYELI LILLY & Co | 1,168,082 | $1.07B |
| GMOptec International, Inc. | 12,848,239 | $957.2M |
| INSMINSMED Inc | 5,642,725 | $922.7M |
| UNHUnitedHealth Group Incorporated Common Stock (DE) | 3,198,020 | $865.4M |
| PFEPFIZER INC | 21,926,362 | $615.7M |
| MRKMerck & Co., Inc. | 4,917,482 | $591.5M |
| ABTABBOTT LABORATORIES | 5,397,254 | $554.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,474,362 | $487.8M |
| JNJJOHNSON & JOHNSON | 1,901,804 | $464.9M |
| NVONovo Nordisk A/S | 9,311,206 | $342.2M |
| MRNAModerna, Inc. | 5,351,332 | $271.8M |
| ABBVAbbVie Inc. | 969,890 | $210.9M |
| MEDPMedpace Holdings Inc. | 432,602 | $207.7M |
| BBIOBridgeBio Pharma, Inc. | 2,545,486 | $189.0M |
| PCVXVaxcyte, Inc. | 2,865,318 | $166.5M |
| PMPhilip Morris International Inc | 850,149 | $140.6M |
| ICLRICON plc | 1,232,255 | $136.4M |
| HALOHALOZYME THERAPEUTICS, INC. | 1,899,408 | $122.8M |
| ELVElevance Health Inc. | 414,192 | $121.3M |
| PTCTPTC THERAPEUTICS, INC. | 1,640,381 | $111.8M |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 248,960 | $111.2M |
| RVMDREVOLUTION MEDICINES, INC. | 1,078,498 | $104.9M |
| AMGNAMGEN INC | 292,409 | $102.9M |
| AXSMAxsome Therapeutics, Inc. | 607,165 | $102.6M |
| ARGXARGENX SE | 134,022 | $97.9M |
| IBRXImmunityBio, Inc. | 12,571,597 | $96.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 2,681,169 | $90.7M |
| CAHCardinal Health Inc. | 385,670 | $81.5M |
| DVADaVita Inc. | 504,639 | $77.6M |
| OSCROscar Health Inc. | 6,570,785 | $75.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,192,838 | $74.8M |
| NTLAIntellia Therapeutics, Inc. | 5,728,177 | $73.4M |
| COGTCogent Biosciences, Inc. | 1,868,389 | $71.9M |
| UTHRUNITED THERAPEUTICS Corp | 119,106 | $70.6M |
| MCKMcKesson Corporation | 79,747 | $69.0M |
| RIOTRiot Platforms, Inc. | 5,455,200 | $67.4M |
| MDGLMADRIGAL PHARMACEUTICALS, INC. | 127,339 | $66.7M |
| NVAXNOVAVAX INC | 8,094,658 | $65.9M |
| BMYBRISTOL MYERS SQUIBB CO | 1,059,538 | $64.3M |
| INSPInspire Medical Systems Inc. | 1,199,637 | $61.9M |
| ARQTArcutis Biotherapeutics, Inc. | 2,496,222 | $58.8M |
| JAZZJazz Pharmaceuticals plc | 298,090 | $56.4M |
| TARSTarsus Pharmaceuticals, Inc. | 791,146 | $55.5M |
| VKTXViking Therapeutics, Inc. | 1,676,713 | $54.6M |
| RPRXRoyalty Pharma plc | 1,122,047 | $53.8M |
| VTRSViatris Inc | 3,882,541 | $52.5M |
| CYTKCYTOKINETICS INC | 747,331 | $49.3M |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | 2,602,543 | $48.2M |
| CORTCORCEPT THERAPEUTICS INC | 1,181,348 | $47.6M |
| KNSAKiniksa Pharmaceuticals International, plc | 959,257 | $46.2M |
| XERSXeris Biopharma Holdings, Inc. | 7,788,811 | $45.2M |
| PCRXPacira BioSciences, Inc. | 1,982,724 | $44.8M |
| MLTXMoonLake Immunotherapeutics | 2,390,661 | $44.6M |
| SMMTSummit Therapeutics Inc. | 2,242,229 | $42.5M |
| CORCencora Inc. | 134,365 | $42.2M |
| GHGuardant Health Inc. | 443,375 | $41.0M |
| ROIVRoivant Sciences Ltd. | 1,392,748 | $38.6M |
| ARVNARVINAS, INC. | 3,638,567 | $38.6M |
| SNDXSyndax Pharmaceuticals Inc | 1,601,896 | $37.4M |
| LQDALiquidia Corp | 909,265 | $34.3M |
| GEHCGE HealthCare Technologies Inc. | 480,374 | $34.2M |
| CRLCHARLES RIVER LABORATORIES INTERNATIONAL, INC. | 193,483 | $33.4M |
| IONSIONIS PHARMACEUTICALS INC | 429,599 | $32.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 622,450 | $32.2M |
| ANABANAPTYSBIO, INC | 579,296 | $32.1M |
| NEONeoGenomics Inc. | 4,164,183 | $30.9M |
| GILDGILEAD SCIENCES, INC. | 220,919 | $30.8M |
| DGXQuest Diagnostics Incorporated | 147,727 | $29.0M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 8,016,353 | $28.1M |
| ADPTAdaptive Biotechnologies Corp | 1,965,610 | $27.3M |
| RAREUltragenyx Pharmaceutical Inc. | 1,261,018 | $26.4M |
| CNTACentessa Pharmaceuticals plc | 643,808 | $25.6M |
| ALKSAlkermes plc. | 710,297 | $25.1M |
| TVTXTravere Therapeutics, Inc. | 836,544 | $24.9M |
| MOHMolina Healthcare Inc | 185,783 | $24.8M |
| VRDNViridian Therapeutics, Inc.\DE | 1,262,540 | $24.7M |
| BHVNBiohaven Ltd. | 2,847,193 | $24.1M |
| MLYSMineralys Therapeutics, Inc. | 887,192 | $24.0M |
| REGNREGENERON PHARMACEUTICALS, INC. | 30,530 | $23.6M |
| BNTXBioNTech SE | 264,768 | $23.5M |
| AUPHAurinia Pharmaceuticals Inc. | 1,572,983 | $23.3M |
| PBIPROVENTION BIO, INC. | 2,100,701 | $23.2M |
| PBHPrestige Consumer Healthcare Inc. | 381,033 | $22.6M |
| MYGNMYRIAD GENETICS INC | 4,499,724 | $20.2M |
| TGTXTG THERAPEUTICS, INC. | 605,247 | $20.1M |
| TSHATaysha Gene Therapies, Inc. | 4,427,301 | $19.8M |
| ERASErasca, Inc. | 1,219,534 | $19.7M |
| CRONCronos Group Inc. | 7,618,227 | $19.1M |
| URGNUroGen Pharma Ltd. | 1,023,159 | $18.4M |
| ESPREsperion Therapeutics, Inc. | 6,540,785 | $17.9M |
| REPLReplimune Group, Inc. | 2,336,528 | $17.9M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 530,698 | $17.6M |
| LGNDLigand Pharmaceuticals Incorporated | 87,228 | $17.4M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 1,763,347 | $17.1M |
| ANIPANI PHARMACEUTICALS INC | 213,433 | $16.4M |
| ACADACADIA PHARMACEUTICALS INC | 729,836 | $16.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 282,460 | $16.0M |
| OGNOrganon & Co. | 2,662,152 | $15.9M |
| TBPHTheravance Biopharma, Inc. | 954,042 | $15.5M |
| MIRMMirum Pharmaceuticals, Inc. | 167,489 | $15.5M |
| CCXIChemoCentryx, Inc. | 1,297,180 | $13.2M |
| SRPTSarepta Therapeutics, Inc. | 601,786 | $13.1M |
| AMPHAmphastar Pharmaceuticals, Inc. | 665,542 | $13.0M |
| ALMSALUMIS INC. | 572,129 | $12.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 149,609 | $12.6M |
| FULCFulcrum Therapeutics, Inc. | 1,623,281 | $12.5M |
| BIOABioAge Labs, Inc. | 699,190 | $12.2M |
| RIGLRIGEL PHARMACEUTICALS INC | 445,678 | $12.1M |
| NBIXNEUROCRINE BIOSCIENCES INC | 89,184 | $11.7M |
| SVRASavara Inc | 2,111,882 | $11.5M |
| NVSNovartis AG | 70,100 | $10.7M |
| TERNTerns Pharmaceuticals, Inc. | 201,191 | $10.6M |
| IMCRImmunocore Holdings plc | 335,191 | $10.1M |
| GPCRStructure Therapeutics Inc. | 204,790 | $9.9M |
| FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share) | 429,332 | $9.7M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 315,000 | $9.6M |
| VCELVericel Corp | 295,626 | $9.5M |
| AVNSAvanos Medical Inc. | 671,413 | $9.4M |
| MMSIMerit Medical Systems Inc. | 134,156 | $9.2M |
| ZTSZoetis Inc. | 77,249 | $9.1M |
| PHVSPharvaris N.V. | 321,157 | $9.1M |
| KODKodiak Sciences Inc. | 229,955 | $8.8M |
| MBXMBX Biosciences, Inc. | 288,889 | $8.6M |
| AVBPArriVent BioPharma, Inc. | 368,795 | $8.5M |
| MANEVeradermics Incorporated | 134,219 | $8.5M |
| EBSEmergent BioSolutions Inc. | 1,003,912 | $8.3M |
| ZVRAZEVRA THERAPEUTICS, INC. | 846,457 | $7.9M |
| RCKTRocket Pharmaceuticals Inc. | 2,169,625 | $7.8M |
| FLGTFulgent Genetics Inc. | 486,770 | $7.7M |
| ELVNEnliven Therapeutics, Inc. | 193,531 | $7.6M |
| ACHAccendra Health Inc. | 3,311,601 | $7.6M |
| APLSApellis Pharmaceuticals, Inc. | 186,853 | $7.5M |
| QDELQuidelOrtho Corp | 450,099 | $7.4M |
| UPBUpstream Bio, Inc. | 820,480 | $7.4M |
| VIRVir Biotechnology, Inc. | 817,685 | $7.3M |
| ALECAlector, Inc. | 3,332,835 | $7.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 488,098 | $7.1M |
| CRSPCRISPR Therapeutics AG | 142,700 | $6.8M |
| ALLOAllogene Therapeutics, Inc. | 2,763,776 | $6.7M |
| INBXInhibrx Biosciences, Inc. | 100,137 | $6.7M |
| GLPGGalapagos NV | 215,718 | $6.5M |
| KYTXKyverna Therapeutics, Inc. | 721,581 | $6.2M |
| INDVIndivior Pharmaceuticals, Inc. | 203,985 | $6.2M |
| ABVXAbivax SA | 55,150 | $6.1M |
| ARRYARRAY BIOPHARMA INC | 823,628 | $6.0M |
| ZYMEZymeworks Inc. | 235,621 | $5.9M |
| AGLagilon health inc. | 742,218 | $5.9M |
| INVAInnoviva, Inc. | 248,819 | $5.8M |
| KROSKeros Therapeutics, Inc. | 509,608 | $5.6M |
| RCUSArcus Biosciences, Inc. | 259,400 | $5.6M |
| BCAXBicara Therapeutics Inc. | 276,943 | $5.5M |
| RAPPRapport Therapeutics, Inc. | 175,449 | $5.5M |
| ORGOOrganogenesis Holdings Inc. | 2,297,974 | $5.4M |
| RZLTRezolute, Inc. | 1,765,980 | $5.4M |
| NRIXNurix Therapeutics, Inc. | 344,203 | $5.3M |
| CSTLCastle Biosciences Inc. | 211,966 | $5.2M |
| DFTXDefinium Therapeutics Inc. | 271,717 | $5.1M |
| ADMAADMA BIOLOGICS, INC. | 560,827 | $5.1M |
| DSGNDesign Therapeutics, Inc. | 470,270 | $5.0M |
| APGEApogee Therapeutics, Inc. | 58,835 | $5.0M |
| AZNASTRAZENECA PLC | 25,005 | $4.9M |
| HLFHerbalife Ltd. | 331,107 | $4.9M |
| PRMEPrime Medicine, Inc. | 1,393,621 | $4.8M |
| EDITEditas Medicine, Inc. | 1,943,893 | $4.8M |
| QUREuniQure N.V. | 268,014 | $4.4M |
| TEVATeva Pharmaceutical Industries Limited | 140,073 | $4.2M |
| BIIBBIOGEN INC. | 21,900 | $4.0M |
| ANNXAnnexon, Inc. | 702,799 | $3.9M |
| ACHCAcadia Healthcare Company Inc. | 165,121 | $3.9M |
| INOINOVIO PHARMACEUTICALS, INC. | 2,212,819 | $3.9M |
| PRGOPERRIGO Co plc | 348,281 | $3.7M |
| MGTXMeiraGTx Holdings plc | 425,281 | $3.7M |
| TECXTectonic Therapeutic, Inc. | 116,120 | $3.6M |
| WSTWest Pharmaceutical Services Inc. | 14,001 | $3.5M |
| ZNTLZentalis Pharmaceuticals, Inc. | 1,484,098 | $3.5M |
| ELANElanco Animal Health Inc | 145,018 | $3.5M |
| ACRSAclaris Therapeutics, Inc. | 900,804 | $3.4M |
| BHCBausch Health Companies Inc. | 621,755 | $3.4M |
| ANIKAnika Therapeutics Inc. | 229,796 | $3.3M |
| EWTXEdgewise Therapeutics, Inc. | 104,863 | $3.3M |
| NUSNu Skin Enterprises Inc. | 444,086 | $3.2M |
| USNAUSANA HEALTH SCIENCES INC | 182,483 | $3.2M |
| CGONCG Oncology, Inc. | 46,610 | $3.2M |
| ZBHZimmer Biomet Holdings Inc. | 34,746 | $3.1M |
| RGENREPLIGEN CORP | 26,300 | $3.1M |
| MGNXMACROGENICS INC | 1,058,424 | $3.1M |
| BCRXBIOCRYST PHARMACEUTICALS INC | 302,101 | $2.9M |
| HRMYHarmony Biosciences Holdings, Inc. | 101,427 | $2.8M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 32,652 | $2.8M |
| BVSBioventus Inc. | 310,610 | $2.8M |
| CCCCC4 Therapeutics, Inc. | 1,060,331 | $2.8M |
| KRYSKrystal Biotech, Inc. | 10,396 | $2.7M |
| LRMRLarimar Therapeutics, Inc. | 575,624 | $2.6M |
| GMEDGlobus Medical Inc. | 28,359 | $2.4M |
| SIGASIGA TECHNOLOGIES INC | 456,385 | $2.4M |
| RGNXREGENXBIO Inc. | 286,001 | $2.4M |
| ALDXAldeyra Therapeutics, Inc. | 1,403,990 | $2.4M |
| CAICaris Life Sciences Inc. | 129,577 | $2.3M |
| EOLSEvolus, Inc. | 559,050 | $2.3M |
| XENEXenon Pharmaceuticals Inc. | 38,740 | $2.3M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 351,235 | $2.2M |
| ALTAltimmune, Inc. | 727,001 | $2.2M |
| TWSTTwist Bioscience Corp | 46,644 | $2.2M |
| TRVITrevi Therapeutics, Inc. | 181,344 | $2.2M |
| SGMTSagimet Biosciences Inc. | 411,570 | $2.2M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 2,600,990 | $2.1M |
| IPEXInflection Point Acquisition Corp. V | 200,000 | $2.1M |
| AVIRAtea Pharmaceuticals, Inc. | 379,314 | $2.0M |
| PGNYProgyny Inc. | 119,072 | $2.0M |
| ALHCAlignment Healthcare Inc. | 113,292 | $2.0M |
| ABSIAbsci Corporation | 649,817 | $1.9M |
| ARCTArcturus Therapeutics Holdings Inc. | 252,034 | $1.9M |
| RDYDR REDDYS LABORATORIES LTD | 138,551 | $1.9M |
| ARDXARDELYX, INC. | 313,961 | $1.9M |
| OCULOCULAR THERAPEUTIX, INC | 218,478 | $1.9M |
| SKINThe Beauty Health Company | 1,898,475 | $1.7M |
| NUVBNuvation Bio Inc. | 392,986 | $1.7M |
| CLDXCelldex Therapeutics, Inc. | 52,860 | $1.7M |
| STOKStoke Therapeutics, Inc. | 49,972 | $1.6M |
| PRAXPraxis Precision Medicines, Inc. | 5,000 | $1.6M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 29,100 | $1.6M |
| TLRYTilray Brands, Inc. | 237,771 | $1.5M |
| PHATPhathom Pharmaceuticals, Inc. | 132,457 | $1.5M |
| JANXJanux Therapeutics, Inc. | 98,395 | $1.4M |
| MAZEMaze Therapeutics, Inc. | 45,636 | $1.4M |
| CYRXCryoport, Inc. | 158,225 | $1.3M |
| CMPSCOMPASS Pathways plc | 236,380 | $1.3M |
| MDXGMiMedx Group Inc | 312,696 | $1.2M |
| NAGENiagen Bioscience, Inc. | 277,381 | $1.2M |
| ZLABZai Lab Ltd | 63,243 | $1.2M |
| GENBGenerate Biomedicines Inc. | 95,000 | $1.2M |
| TMCITreace Medical Concepts Inc. | 841,269 | $1.1M |
| DRUGBRIGHT MINDS BIOSCIENCES INC. | 15,445 | $1.1M |
| GLUEMonte Rosa Therapeutics, Inc. | 66,327 | $1.1M |
| AMLXAmylyx Pharmaceuticals, Inc. | 74,230 | $1.0M |
| ANROAlto Neuroscience, Inc. | 45,343 | $1.0M |
| SLNOSOLENO THERAPEUTICS INC | 30,247 | $1.0M |
| CPRXCATALYST PHARMACEUTICALS, INC. | 40,542 | $1.0M |
| TRDAEntrada Therapeutics, Inc. | 79,047 | $998K |
| FLNAFilana Therapeutics Inc. | 559,205 | $945K |
| SLDBSolid Biosciences Inc. | 128,348 | $924K |
| ADCTADC Therapeutics SA | 243,176 | $912K |
| ENTAENANTA PHARMACEUTICALS INC | 70,884 | $895K |
| BKHABlack Hawk Acquisition Corporation | 75,000 | $866K |
| IQVIQVIA Holdings Inc. | 5,000 | $853K |
| QGENQIAGEN N.V. | 19,397 | $777K |
| BDTXBlack Diamond Therapeutics, Inc. | 363,921 | $775K |
| SDGRSchrodinger, Inc. | 67,141 | $763K |
| NKTXNkarta, Inc. | 356,932 | $753K |
| OMEROMEROS CORP | 71,168 | $752K |
| SRRKScholar Rock Holding Corp | 14,644 | $720K |
| NRCNational Research Corporation Common Stock (Delaware) | 40,000 | $679K |
| ABUSArbutus Biopharma Corp | 143,201 | $644K |
| IDXXIDEXX LABORATORIES INC /DE | 1,074 | $603K |
| OABIOmniAb Inc. | 380,254 | $597K |
| OLMAOlema Pharmaceuticals, Inc. | 39,230 | $585K |
| NPCENeuropace Inc. | 43,625 | $574K |
| ORICOric Pharmaceuticals, Inc. | 44,390 | $562K |
| UTMDUtah Medical Products Inc. | 8,735 | $541K |
| WVEWave Life Sciences Ltd. | 72,305 | $524K |
| CGCCanopy Growth Corp | 541,753 | $514K |
| CABACabaletta Bio, Inc. | 189,412 | $510K |
| ONCBeOne Medicines Ltd. | 1,600 | $475K |
| PAHCPHIBRO ANIMAL HEALTH CORP | 8,454 | $468K |
| DAWNDay One Biopharmaceuticals, Inc. | 21,626 | $464K |
| ABEOABEONA THERAPEUTICS INC. | 101,065 | $453K |
| VYGRVoyager Therapeutics, Inc. | 98,716 | $381K |
| CMPXCompass Therapeutics, Inc. | 65,967 | $349K |
| TCRXTScan Therapeutics, Inc. | 319,587 | $323K |
| AKTSAktis Oncology Inc. | 17,062 | $305K |
| INCYIncyte Corp. | 3,200 | $301K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 13,726 | $296K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 26,474 | $249K |
| ACBAURORA CANNABIS INC | 74,117 | $243K |
| FDMT4D Molecular Therapeutics, Inc. | 24,030 | $224K |
| VERAVera Therapeutics, Inc. | 5,500 | $221K |
| BAXBaxter International Inc. | 10,737 | $180K |
| IRWDIRONWOOD PHARMACEUTICALS INC | 47,938 | $168K |
| DNAGinkgo Bioworks Holdings Inc. | 27,169 | $167K |
| AGMBAgomAb Therapeutics NV | 15,326 | $161K |
| CLOVClover Health Investments Corp. | 91,011 | $160K |
| VSTMVerastem, Inc. | 26,659 | $141K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 46,008 | $141K |
| MXCTMaxCyte Inc. | 200,505 | $141K |
| AVXLANAVEX LIFE SCIENCES CORP. | 44,856 | $138K |
| GOSSGossamer Bio, Inc. | 389,431 | $128K |
| SANASana Biotechnology, Inc. | 38,670 | $111K |
| AGENAGENUS INC | 33,269 | $111K |
| ATAIAtai Beckley N.V. | 27,419 | $97K |
| SPRYARS Pharmaceuticals, Inc. | 11,873 | $95K |
| ALGSAligos Therapeutics, Inc. | 10,978 | $82K |
| AQSTAquestive Therapeutics, Inc. | 18,149 | $75K |
| AKBAAkebia Therapeutics, Inc. | 16,106 | $22K |
| BKHARBlack Hawk Acquisition Corp | 15,000 | $20K |