| INSMINSMED Inc | 5,625,825 | $919.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,059,062 | $350.4M |
| BBIOBridgeBio Pharma, Inc. | 2,545,486 | $189.0M |
| PCVXVaxcyte, Inc. | 2,865,318 | $166.5M |
| EXELEXELIXIS, INC. | 3,603,063 | $154.5M |
| PTCTPTC THERAPEUTICS, INC. | 1,640,381 | $111.8M |
| AXSMAxsome Therapeutics, Inc. | 603,465 | $102.0M |
| RVMDREVOLUTION MEDICINES, INC. | 1,022,298 | $99.4M |
| IBRXImmunityBio, Inc. | 12,571,597 | $96.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 2,681,169 | $90.7M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,183,838 | $74.2M |
| NTLAIntellia Therapeutics, Inc. | 5,728,177 | $73.4M |
| COGTCogent Biosciences, Inc. | 1,868,389 | $71.9M |
| ARQTArcutis Biotherapeutics, Inc. | 2,496,222 | $58.8M |
| JAZZJazz Pharmaceuticals plc | 298,090 | $56.4M |
| VKTXViking Therapeutics, Inc. | 1,676,713 | $54.6M |
| CYTKCYTOKINETICS INC | 706,631 | $46.6M |
| KNSAKiniksa Pharmaceuticals International, plc | 959,257 | $46.2M |
| XERSXeris Biopharma Holdings, Inc. | 7,788,811 | $45.2M |
| MLTXMoonLake Immunotherapeutics | 2,390,661 | $44.6M |
| SMMTSummit Therapeutics Inc. | 2,242,229 | $42.5M |
| ROIVRoivant Sciences Ltd. | 1,392,748 | $38.6M |
| ARVNARVINAS, INC. | 3,638,567 | $38.6M |
| ARGXARGENX SE | 52,122 | $38.1M |
| MRNAModerna, Inc. | 666,532 | $33.9M |
| LQDALiquidia Corp | 873,065 | $32.9M |
| IONSIONIS PHARMACEUTICALS INC | 429,599 | $32.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 622,450 | $32.2M |
| ANABANAPTYSBIO, INC | 579,296 | $32.1M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 8,016,353 | $28.1M |
| GILDGILEAD SCIENCES, INC. | 200,919 | $28.0M |
| ADPTAdaptive Biotechnologies Corp | 1,965,610 | $27.3M |
| CNTACentessa Pharmaceuticals plc | 643,808 | $25.6M |
| TVTXTravere Therapeutics, Inc. | 836,544 | $24.9M |
| VRDNViridian Therapeutics, Inc.\DE | 1,262,540 | $24.7M |
| BHVNBiohaven Ltd. | 2,847,193 | $24.1M |
| TGTXTG THERAPEUTICS, INC. | 590,047 | $19.6M |
| ESPREsperion Therapeutics, Inc. | 6,540,785 | $17.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 22,730 | $17.6M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 1,763,347 | $17.1M |
| ANIPANI PHARMACEUTICALS INC | 213,433 | $16.4M |
| ACADACADIA PHARMACEUTICALS INC | 729,836 | $16.2M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 282,460 | $16.0M |
| OGNOrganon & Co. | 2,644,552 | $15.8M |
| LGNDLigand Pharmaceuticals Incorporated | 78,428 | $15.7M |
| ALMSALUMIS INC. | 572,129 | $12.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 149,609 | $12.6M |
| BIOABioAge Labs, Inc. | 699,190 | $12.2M |
| SVRASavara Inc | 2,111,882 | $11.5M |
| TERNTerns Pharmaceuticals, Inc. | 201,191 | $10.6M |
| IMCRImmunocore Holdings plc | 335,191 | $10.1M |
| GPCRStructure Therapeutics Inc. | 204,790 | $9.9M |
| VCELVericel Corp | 295,626 | $9.5M |
| PHVSPharvaris N.V. | 321,157 | $9.1M |
| KODKodiak Sciences Inc. | 229,955 | $8.8M |
| MANEVeradermics Incorporated | 134,219 | $8.5M |
| ZVRAZEVRA THERAPEUTICS, INC. | 846,457 | $7.9M |
| RCKTRocket Pharmaceuticals Inc. | 2,169,625 | $7.8M |
| FLGTFulgent Genetics Inc. | 486,770 | $7.7M |
| ELVNEnliven Therapeutics, Inc. | 193,531 | $7.6M |
| APLSApellis Pharmaceuticals, Inc. | 186,853 | $7.5M |
| UPBUpstream Bio, Inc. | 820,480 | $7.4M |
| ALECAlector, Inc. | 3,332,835 | $7.2M |
| FOLDAMICUS THERAPEUTICS, INC. | 488,098 | $7.1M |
| ZYMEZymeworks Inc. | 235,621 | $5.9M |
| INVAInnoviva, Inc. | 248,819 | $5.8M |
| ABVXAbivax SA | 50,550 | $5.6M |
| KROSKeros Therapeutics, Inc. | 509,608 | $5.6M |
| RCUSArcus Biosciences, Inc. | 259,400 | $5.6M |
| BCAXBicara Therapeutics Inc. | 276,943 | $5.5M |
| ORGOOrganogenesis Holdings Inc. | 2,297,974 | $5.4M |
| RZLTRezolute, Inc. | 1,765,980 | $5.4M |
| NRIXNurix Therapeutics, Inc. | 344,203 | $5.3M |
| DFTXDefinium Therapeutics Inc. | 271,717 | $5.1M |
| ADMAADMA BIOLOGICS, INC. | 560,827 | $5.1M |
| DSGNDesign Therapeutics, Inc. | 470,270 | $5.0M |
| APGEApogee Therapeutics, Inc. | 58,835 | $5.0M |
| TEVATeva Pharmaceutical Industries Limited | 140,073 | $4.2M |
| ANNXAnnexon, Inc. | 702,799 | $3.9M |
| INOINOVIO PHARMACEUTICALS, INC. | 2,212,819 | $3.9M |
| TECXTectonic Therapeutic, Inc. | 116,120 | $3.6M |
| ZNTLZentalis Pharmaceuticals, Inc. | 1,484,098 | $3.5M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 32,652 | $2.8M |
| CCCCC4 Therapeutics, Inc. | 1,060,331 | $2.8M |
| QUREuniQure N.V. | 160,714 | $2.6M |
| LRMRLarimar Therapeutics, Inc. | 575,624 | $2.6M |
| SIGASIGA TECHNOLOGIES INC | 456,385 | $2.4M |
| RGNXREGENXBIO Inc. | 286,001 | $2.4M |
| ALDXAldeyra Therapeutics, Inc. | 1,403,990 | $2.4M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 351,235 | $2.2M |
| ALTAltimmune, Inc. | 727,001 | $2.2M |
| SGMTSagimet Biosciences Inc. | 411,570 | $2.2M |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 2,600,990 | $2.1M |
| ABSIAbsci Corporation | 649,817 | $1.9M |
| RDYDR REDDYS LABORATORIES LTD | 138,551 | $1.9M |
| ARDXARDELYX, INC. | 313,961 | $1.9M |
| OCULOCULAR THERAPEUTIX, INC | 218,478 | $1.9M |
| NUVBNuvation Bio Inc. | 392,986 | $1.7M |
| CLDXCelldex Therapeutics, Inc. | 52,860 | $1.7M |
| STOKStoke Therapeutics, Inc. | 49,972 | $1.6M |
| MAZEMaze Therapeutics, Inc. | 45,636 | $1.4M |
| CMPSCOMPASS Pathways plc | 236,380 | $1.3M |
| SLNOSOLENO THERAPEUTICS INC | 30,247 | $1.0M |
| TRDAEntrada Therapeutics, Inc. | 79,047 | $998K |
| FLNAFilana Therapeutics Inc. | 559,205 | $945K |
| SLDBSolid Biosciences Inc. | 128,348 | $924K |
| BDTXBlack Diamond Therapeutics, Inc. | 363,921 | $775K |
| SRRKScholar Rock Holding Corp | 14,644 | $720K |
| ABUSArbutus Biopharma Corp | 143,201 | $644K |
| OLMAOlema Pharmaceuticals, Inc. | 39,230 | $585K |
| ORICOric Pharmaceuticals, Inc. | 44,390 | $562K |
| DAWNDay One Biopharmaceuticals, Inc. | 21,626 | $464K |
| ABEOABEONA THERAPEUTICS INC. | 101,065 | $453K |
| VYGRVoyager Therapeutics, Inc. | 98,716 | $381K |
| CMPXCompass Therapeutics, Inc. | 65,967 | $349K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 13,726 | $296K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 26,474 | $249K |
| FDMT4D Molecular Therapeutics, Inc. | 24,030 | $224K |
| DNAGinkgo Bioworks Holdings Inc. | 27,169 | $167K |
| AGMBAgomAb Therapeutics NV | 15,326 | $161K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 46,008 | $141K |
| AVXLANAVEX LIFE SCIENCES CORP. | 44,856 | $138K |
| SANASana Biotechnology, Inc. | 38,670 | $111K |
| AGENAGENUS INC | 33,269 | $111K |
| ATAIAtai Beckley N.V. | 27,419 | $97K |
| SPRYARS Pharmaceuticals, Inc. | 11,873 | $95K |
| ALGSAligos Therapeutics, Inc. | 10,978 | $82K |
| AQSTAquestive Therapeutics, Inc. | 18,149 | $75K |