| REGNREGENERON PHARMACEUTICALS, INC. | 1,231,008 | $946.0M |
| EXELEXELIXIS, INC. | 13,095,741 | $561.7M |
| INCYIncyte Corp. | 5,807,930 | $536.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 7,676,541 | $429.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 913,104 | $297.9M |
| JAZZJazz Pharmaceuticals plc | 1,338,458 | $249.9M |
| GILDGILEAD SCIENCES, INC. | 1,164,803 | $162.1M |
| ROIVRoivant Sciences Ltd. | 5,946,858 | $161.6M |
| INSMINSMED Inc | 675,485 | $108.8M |
| PTCTPTC THERAPEUTICS, INC. | 342,106 | $23.3M |
| OGNOrganon & Co. | 3,450,626 | $20.2M |
| KNSAKiniksa Pharmaceuticals International, plc | 378,697 | $18.2M |
| AXSMAxsome Therapeutics, Inc. | 104,059 | $17.6M |
| KURAKura Oncology, Inc. | 2,124,480 | $17.3M |
| APLSApellis Pharmaceuticals, Inc. | 427,970 | $17.2M |
| BHVNBiohaven Ltd. | 1,975,516 | $16.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 283,123 | $15.6M |
| ARDXARDELYX, INC. | 2,439,450 | $14.6M |
| BBIOBridgeBio Pharma, Inc. | 160,112 | $11.9M |
| ACADACADIA PHARMACEUTICALS INC | 527,913 | $11.8M |
| INVAInnoviva, Inc. | 495,841 | $11.6M |
| TGTXTG THERAPEUTICS, INC. | 344,189 | $11.4M |
| RVMDREVOLUTION MEDICINES, INC. | 116,787 | $11.4M |
| ARQTArcutis Biotherapeutics, Inc. | 468,253 | $11.0M |
| RCKTRocket Pharmaceuticals Inc. | 3,069,930 | $11.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 733,198 | $10.6M |
| SRRKScholar Rock Holding Corp | 211,960 | $10.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 167,210 | $10.3M |
| CYTKCYTOKINETICS INC | 156,544 | $10.3M |
| DAWNDay One Biopharmaceuticals, Inc. | 444,467 | $9.5M |
| TERNTerns Pharmaceuticals, Inc. | 176,773 | $9.3M |
| TVTXTravere Therapeutics, Inc. | 305,412 | $9.1M |
| RGNXREGENXBIO Inc. | 1,051,712 | $8.8M |
| NUVBNuvation Bio Inc. | 1,995,758 | $8.6M |
| SMMTSummit Therapeutics Inc. | 443,757 | $8.1M |
| XERSXeris Biopharma Holdings, Inc. | 1,394,376 | $8.1M |
| NTLAIntellia Therapeutics, Inc. | 630,529 | $8.1M |
| COGTCogent Biosciences, Inc. | 189,796 | $7.3M |
| ADPTAdaptive Biotechnologies Corp | 485,233 | $6.7M |
| SIGASIGA TECHNOLOGIES INC | 1,219,677 | $6.5M |
| RDYDR REDDYS LABORATORIES LTD | 445,277 | $6.1M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 59,279 | $5.2M |
| CGEMCullinan Therapeutics, Inc. | 360,874 | $5.1M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 800,194 | $5.1M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 98,257 | $5.1M |
| ALDXAldeyra Therapeutics, Inc. | 2,829,875 | $4.8M |
| ADMAADMA BIOLOGICS, INC. | 514,789 | $4.6M |
| KROSKeros Therapeutics, Inc. | 406,563 | $4.5M |
| ANNXAnnexon, Inc. | 777,253 | $4.3M |
| OCULOCULAR THERAPEUTIX, INC | 499,339 | $4.2M |
| SNYSanofi | 78,929 | $3.8M |
| LRMRLarimar Therapeutics, Inc. | 817,517 | $3.7M |
| FATEFATE THERAPEUTICS INC | 3,001,521 | $3.6M |
| KODKodiak Sciences Inc. | 85,818 | $3.3M |
| SANASana Biotechnology, Inc. | 1,124,279 | $3.2M |
| ALMSALUMIS INC. | 146,682 | $3.2M |
| KRROKorro Bio, Inc. | 267,755 | $3.0M |
| ARVNARVINAS, INC. | 285,118 | $3.0M |
| NUVLNuvalent, Inc. | 26,831 | $2.7M |
| RZLTRezolute, Inc. | 796,696 | $2.4M |
| AVXLANAVEX LIFE SCIENCES CORP. | 756,792 | $2.3M |
| ZYMEZymeworks Inc. | 90,669 | $2.3M |
| TEVATeva Pharmaceutical Industries Limited | 75,218 | $2.3M |
| TNGXTango Therapeutics, Inc. | 107,286 | $2.2M |
| GMABGenmab A/S | 83,279 | $2.2M |
| TNXPTonix Pharmaceuticals Holding Corp. | 161,208 | $2.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 624,168 | $2.2M |
| IONSIONIS PHARMACEUTICALS INC | 28,783 | $2.2M |
| ORICOric Pharmaceuticals, Inc. | 170,087 | $2.2M |
| ABSIAbsci Corporation | 699,439 | $2.1M |
| ORGOOrganogenesis Holdings Inc. | 881,717 | $2.1M |
| CHRSCoherus Oncology, Inc. | 1,206,046 | $2.0M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 204,016 | $2.0M |
| DNLIDenali Therapeutics Inc. | 102,579 | $2.0M |
| MRNAModerna, Inc. | 38,315 | $1.9M |
| RCUSArcus Biosciences, Inc. | 86,294 | $1.9M |
| LQDALiquidia Corp | 48,986 | $1.8M |
| ARGXARGENX SE | 2,530 | $1.8M |
| DNAGinkgo Bioworks Holdings Inc. | 294,788 | $1.8M |
| ANABANAPTYSBIO, INC | 32,467 | $1.8M |
| VCELVericel Corp | 48,690 | $1.6M |
| ALECAlector, Inc. | 711,334 | $1.5M |
| STOKStoke Therapeutics, Inc. | 46,459 | $1.5M |
| LGNDLigand Pharmaceuticals Incorporated | 7,437 | $1.5M |
| PCVXVaxcyte, Inc. | 25,458 | $1.5M |
| ANIPANI PHARMACEUTICALS INC | 18,842 | $1.4M |
| OLMAOlema Pharmaceuticals, Inc. | 89,562 | $1.3M |
| LENZLENZ Therapeutics, Inc. | 140,305 | $1.3M |
| PTGXProtagonist Therapeutics, Inc | 11,874 | $1.3M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 36,410 | $1.2M |
| BIOABioAge Labs, Inc. | 69,334 | $1.2M |
| HUMAHumacyte Inc. | 1,924,691 | $1.2M |
| SLDBSolid Biosciences Inc. | 151,541 | $1.1M |
| HURATuHURA Biosciences, Inc./NV | 607,168 | $1.1M |
| DFTXDefinium Therapeutics Inc. | 57,094 | $1.1M |
| CMPXCompass Therapeutics, Inc. | 200,428 | $1.1M |
| SYRESpyre Therapeutics, Inc. | 20,874 | $1.1M |
| TRDAEntrada Therapeutics, Inc. | 79,493 | $1.0M |
| ZBIOZenas BioPharma, Inc. | 50,971 | $996K |
| IRONDisc Medicine, Inc. | 14,155 | $905K |
| VYGRVoyager Therapeutics, Inc. | 232,681 | $898K |
| OPKOPKO HEALTH, INC. | 763,590 | $870K |
| ESPREsperion Therapeutics, Inc. | 314,866 | $863K |
| MLTXMoonLake Immunotherapeutics | 46,185 | $861K |
| MAZEMaze Therapeutics, Inc. | 27,945 | $834K |
| KALVKalVista Pharmaceuticals, Inc. | 37,572 | $756K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 244,391 | $750K |
| ZVRAZEVRA THERAPEUTICS, INC. | 79,915 | $745K |
| PGENPRECIGEN, INC. | 184,994 | $716K |
| SLNOSOLENO THERAPEUTICS INC | 21,152 | $708K |
| APGEApogee Therapeutics, Inc. | 8,027 | $676K |
| UPBUpstream Bio, Inc. | 72,171 | $650K |
| TECXTectonic Therapeutic, Inc. | 16,934 | $523K |
| RNACCartesian Therapeutics, Inc. | 84,020 | $517K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 641,587 | $513K |
| IBRXImmunityBio, Inc. | 66,547 | $510K |
| AARDAardvark Therapeutics, Inc. | 134,495 | $507K |
| FLGTFulgent Genetics Inc. | 29,444 | $468K |
| ABEOABEONA THERAPEUTICS INC. | 102,645 | $460K |
| FDMT4D Molecular Therapeutics, Inc. | 45,777 | $426K |
| VRDNViridian Therapeutics, Inc.\DE | 20,208 | $395K |
| VKTXViking Therapeutics, Inc. | 12,172 | $390K |
| MESOMesoblast Limited | 25,344 | $390K |
| BEAMBeam Therapeutics Inc. | 15,692 | $374K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 4,118 | $346K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 10,384 | $332K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 10,022 | $305K |
| SVRASavara Inc | 55,177 | $301K |
| DSGNDesign Therapeutics, Inc. | 25,957 | $276K |
| ALTAltimmune, Inc. | 85,454 | $263K |
| BCAXBicara Therapeutics Inc. | 13,186 | $262K |
| NRIXNurix Therapeutics, Inc. | 16,406 | $254K |
| CLDXCelldex Therapeutics, Inc. | 7,777 | $247K |
| GRFSGrifols S.A. | 30,633 | $246K |
| HROWHARROW, INC. | 6,548 | $231K |
| SLSSELLAS Life Sciences Group, Inc. | 53,990 | $228K |
| STROSUTRO BIOPHARMA, INC. | 8,605 | $214K |
| AQSTAquestive Therapeutics, Inc. | 51,594 | $214K |
| NGNENeurogene Inc. | 10,311 | $208K |
| SPRYARS Pharmaceuticals, Inc. | 25,877 | $208K |
| ORKAOruka Therapeutics, Inc. | 4,207 | $206K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 96,234 | $150K |
| FENCFENNEC PHARMACEUTICALS INC. | 24,146 | $148K |
| TVRDTvardi Therapeutics, Inc. | 42,192 | $134K |
| CATXPerspective Therapeutics, Inc. | 26,716 | $111K |
| ABUSArbutus Biopharma Corp | 23,819 | $107K |
| CRDFCardiff Oncology, Inc. | 66,156 | $107K |
| GERNGERON CORP | 59,847 | $89K |
| CADLCandel Therapeutics, Inc. | 18,028 | $88K |
| DMACDiaMedica Therapeutics Inc. | 11,287 | $76K |
| PLXProtalix BioTherapeutics, Inc. | 30,493 | $66K |
| ZNTLZentalis Pharmaceuticals, Inc. | 22,675 | $53K |
| ATAIAtai Beckley N.V. | 11,070 | $39K |
| MEDSDataMeds AI, Inc. | 20,293 | $2K |