| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,802,363 | $596.3M |
| GILDGILEAD SCIENCES, INC. | 3,978,823 | $554.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 562,097 | $434.3M |
| INSMINSMED Inc | 925,799 | $151.4M |
| ARGXARGENX SE | 173,700 | $126.8M |
| IONSIONIS PHARMACEUTICALS INC | 1,663,803 | $124.9M |
| SNYSanofi | 2,148,014 | $103.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,616,008 | $89.2M |
| BBIOBridgeBio Pharma, Inc. | 1,090,326 | $81.0M |
| GPCRStructure Therapeutics Inc. | 1,438,031 | $69.3M |
| VKTXViking Therapeutics, Inc. | 2,078,577 | $67.6M |
| JAZZJazz Pharmaceuticals plc | 328,657 | $62.1M |
| PTGXProtagonist Therapeutics, Inc | 537,320 | $56.6M |
| EXELEXELIXIS, INC. | 1,272,244 | $54.6M |
| INVAInnoviva, Inc. | 1,910,021 | $44.5M |
| NUVLNuvalent, Inc. | 431,067 | $44.2M |
| ADMAADMA BIOLOGICS, INC. | 4,789,011 | $43.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 651,544 | $40.9M |
| SRRKScholar Rock Holding Corp | 707,101 | $34.8M |
| ARQTArcutis Biotherapeutics, Inc. | 1,463,228 | $34.5M |
| COGTCogent Biosciences, Inc. | 890,568 | $34.3M |
| RVMDREVOLUTION MEDICINES, INC. | 335,528 | $32.6M |
| INCYIncyte Corp. | 336,785 | $31.7M |
| CYTKCYTOKINETICS INC | 443,957 | $29.3M |
| CNTACentessa Pharmaceuticals plc | 687,427 | $27.3M |
| CLDXCelldex Therapeutics, Inc. | 856,310 | $27.2M |
| RDYDR REDDYS LABORATORIES LTD | 1,661,333 | $23.0M |
| PCVXVaxcyte, Inc. | 355,854 | $20.7M |
| DNLIDenali Therapeutics Inc. | 935,692 | $18.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 519,455 | $16.6M |
| ANIPANI PHARMACEUTICALS INC | 191,576 | $14.7M |
| GMABGenmab A/S | 538,944 | $14.5M |
| TEVATeva Pharmaceutical Industries Limited | 469,635 | $14.1M |
| NUVBNuvation Bio Inc. | 2,897,078 | $12.4M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,916,346 | $12.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 161,025 | $8.3M |
| LGNDLigand Pharmaceuticals Incorporated | 40,495 | $8.1M |
| SIGASIGA TECHNOLOGIES INC | 1,317,784 | $7.1M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 79,096 | $6.6M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 115,882 | $6.5M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 120,253 | $4.1M |
| BEAMBeam Therapeutics Inc. | 168,673 | $4.0M |
| KURAKura Oncology, Inc. | 486,570 | $4.0M |
| MRNAModerna, Inc. | 76,687 | $3.9M |
| ONCBeOne Medicines Ltd. | 12,346 | $3.7M |
| ORKAOruka Therapeutics, Inc. | 74,386 | $3.6M |
| SPRYARS Pharmaceuticals, Inc. | 428,599 | $3.4M |
| ROIVRoivant Sciences Ltd. | 114,627 | $3.2M |
| OGNOrganon & Co. | 477,736 | $2.9M |
| NTLAIntellia Therapeutics, Inc. | 208,301 | $2.7M |
| ELVNEnliven Therapeutics, Inc. | 62,116 | $2.4M |
| ALMSALUMIS INC. | 102,456 | $2.3M |
| CGEMCullinan Therapeutics, Inc. | 144,107 | $2.0M |
| DAWNDay One Biopharmaceuticals, Inc. | 88,278 | $1.9M |
| ORICOric Pharmaceuticals, Inc. | 146,804 | $1.9M |
| ZYMEZymeworks Inc. | 70,851 | $1.8M |
| ACADACADIA PHARMACEUTICALS INC | 79,266 | $1.8M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 355,806 | $1.2M |
| OLMAOlema Pharmaceuticals, Inc. | 81,734 | $1.2M |
| NRIXNurix Therapeutics, Inc. | 78,057 | $1.2M |
| BCAXBicara Therapeutics Inc. | 51,553 | $1.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 69,479 | $1.0M |
| TRDAEntrada Therapeutics, Inc. | 77,971 | $984K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 310,434 | $953K |
| FDMT4D Molecular Therapeutics, Inc. | 101,511 | $945K |
| ARVNARVINAS, INC. | 85,492 | $906K |
| FLGTFulgent Genetics Inc. | 53,941 | $858K |
| SLDBSolid Biosciences Inc. | 114,392 | $824K |
| UPBUpstream Bio, Inc. | 87,624 | $789K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 79,631 | $774K |
| STOKStoke Therapeutics, Inc. | 23,397 | $762K |
| KROSKeros Therapeutics, Inc. | 64,260 | $709K |
| TVTXTravere Therapeutics, Inc. | 23,814 | $708K |
| DSGNDesign Therapeutics, Inc. | 65,638 | $698K |
| VYGRVoyager Therapeutics, Inc. | 147,647 | $570K |
| ABSIAbsci Corporation | 185,869 | $558K |
| DNAGinkgo Bioworks Holdings Inc. | 87,386 | $536K |
| BIOABioAge Labs, Inc. | 28,903 | $506K |
| JBIOJade Biosciences, Inc. | 33,369 | $469K |
| CMPXCompass Therapeutics, Inc. | 78,328 | $414K |
| ORGOOrganogenesis Holdings Inc. | 168,372 | $399K |
| KODKodiak Sciences Inc. | 10,356 | $395K |
| TECXTectonic Therapeutic, Inc. | 12,534 | $387K |
| ABCLAbCellera Biologics Inc. | 109,011 | $380K |
| NGNENeurogene Inc. | 18,540 | $374K |
| KNSAKiniksa Pharmaceuticals International, plc | 7,302 | $352K |
| LRMRLarimar Therapeutics, Inc. | 77,636 | $349K |
| PTCTPTC THERAPEUTICS, INC. | 5,003 | $341K |
| FBRXForte Biosciences, Inc. | 12,699 | $329K |
| LYELLyell Immunopharma, Inc. | 15,971 | $320K |
| SGMTSagimet Biosciences Inc. | 60,369 | $315K |
| MAZEMaze Therapeutics, Inc. | 9,635 | $288K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 9,154 | $254K |
| HROWHARROW, INC. | 7,060 | $249K |
| CCCCC4 Therapeutics, Inc. | 85,444 | $225K |
| RCKTRocket Pharmaceuticals Inc. | 57,562 | $206K |
| ZURAZura Bio Ltd | 33,733 | $201K |
| BDTXBlack Diamond Therapeutics, Inc. | 91,046 | $194K |
| ALTAltimmune, Inc. | 62,909 | $194K |
| TNXPTonix Pharmaceuticals Holding Corp. | 12,850 | $177K |
| CATXPerspective Therapeutics, Inc. | 35,722 | $149K |
| SABSSAB BIOTHERAPEUTICS, INC. | 37,455 | $143K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 15,139 | $142K |
| CNTXContext Therapeutics Inc. | 50,912 | $133K |
| ZNTLZentalis Pharmaceuticals, Inc. | 48,572 | $114K |
| ORMPORAMED PHARMACEUTICALS INC. | 32,307 | $110K |
| BHVNBiohaven Ltd. | 11,368 | $96K |
| FLNAFilana Therapeutics Inc. | 53,367 | $90K |
| CHRSCoherus Oncology, Inc. | 43,242 | $73K |
| ANNXAnnexon, Inc. | 12,463 | $69K |
| ABEOABEONA THERAPEUTICS INC. | 12,718 | $57K |
| PRLDPrelude Therapeutics Inc | 10,294 | $35K |