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| ABBVAbbVie Inc. | 3,299,346 | $717.6M |
| JNJJOHNSON & JOHNSON | 2,877,878 | $703.5M |
| MRKMerck & Co., Inc. | 5,547,858 | $667.4M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,802,363 | $596.3M |
| GILDGILEAD SCIENCES, INC. | 3,978,823 | $554.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 562,097 | $434.3M |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 813,285 | $363.2M |
| ZBHZimmer Biomet Holdings Inc. | 3,963,206 | $358.4M |
| AZNASTRAZENECA PLC | 1,807,026 | $356.4M |
| IDXXIDEXX LABORATORIES INC /DE | 599,931 | $337.1M |
| UNHUnitedHealth Group Incorporated Common Stock (DE) | 958,339 | $259.3M |
| CORCencora Inc. | 803,602 | $252.4M |
| ALKSAlkermes plc. | 6,072,103 | $214.7M |
| GMOptec International, Inc. | 2,492,165 | $185.7M |
| DGXQuest Diagnostics Incorporated | 867,331 | $170.0M |
| IQVIQVIA Holdings Inc. | 961,429 | $164.0M |
| INSMINSMED Inc | 925,799 | $151.4M |
| LNTHLantheus Holdings, Inc. | 1,781,106 | $135.1M |
| GEHCGE HealthCare Technologies Inc. | 1,877,533 | $133.6M |
| ARGXARGENX SE | 173,700 | $126.8M |
| IONSIONIS PHARMACEUTICALS INC | 1,663,803 | $124.9M |
| NVSNovartis AG | 703,178 | $107.4M |
| SNYSanofi | 2,148,014 | $103.5M |
| CPRXCATALYST PHARMACEUTICALS, INC. | 4,138,416 | $102.5M |
| WSTWest Pharmaceutical Services Inc. | 399,700 | $100.2M |
| ZTSZoetis Inc. | 834,384 | $98.6M |
| BMYBRISTOL MYERS SQUIBB CO | 1,614,388 | $97.9M |
| MCKMcKesson Corporation | 111,093 | $96.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,616,008 | $89.2M |
| TECHBIO-TECHNE Corp | 1,650,060 | $86.2M |
| MDGLMADRIGAL PHARMACEUTICALS, INC. | 163,933 | $85.8M |
| BBIOBridgeBio Pharma, Inc. | 1,090,326 | $81.0M |
| OSCROscar Health Inc. | 7,029,356 | $80.6M |
| GHGuardant Health Inc. | 867,537 | $80.1M |
| GPCRStructure Therapeutics Inc. | 1,438,031 | $69.3M |
| VKTXViking Therapeutics, Inc. | 2,078,577 | $67.6M |
| VTRSViatris Inc | 4,629,065 | $62.5M |
| AMGNAMGEN INC | 177,650 | $62.5M |
| JAZZJazz Pharmaceuticals plc | 328,657 | $62.1M |
| HRMYHarmony Biosciences Holdings, Inc. | 2,105,179 | $59.0M |
| PTGXProtagonist Therapeutics, Inc | 537,320 | $56.6M |
| ABTABBOTT LABORATORIES | 465,878 | $47.8M |
| QDELQuidelOrtho Corp | 2,856,132 | $46.9M |
| GLUEMonte Rosa Therapeutics, Inc. | 2,809,647 | $46.2M |
| NVONovo Nordisk A/S | 1,211,319 | $44.5M |
| INVAInnoviva, Inc. | 1,910,021 | $44.5M |
| NUVLNuvalent, Inc. | 431,067 | $44.2M |
| ADMAADMA BIOLOGICS, INC. | 4,789,011 | $43.1M |
| PRAXPraxis Precision Medicines, Inc. | 128,254 | $41.3M |
| UTHRUNITED THERAPEUTICS Corp | 69,368 | $41.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 651,544 | $40.9M |
| XENEXenon Pharmaceuticals Inc. | 679,314 | $39.5M |
| CRNXCrinetics Pharmaceuticals, Inc. | 1,052,858 | $38.2M |
| EWTXEdgewise Therapeutics, Inc. | 1,147,176 | $36.1M |
| SRRKScholar Rock Holding Corp | 707,101 | $34.8M |
| ARQTArcutis Biotherapeutics, Inc. | 1,463,228 | $34.5M |
| COGTCogent Biosciences, Inc. | 890,568 | $34.3M |
| RVMDREVOLUTION MEDICINES, INC. | 335,528 | $32.6M |
| INCYIncyte Corp. | 336,785 | $31.7M |
| PFEPFIZER INC | 1,087,523 | $30.5M |
| CAHCardinal Health Inc. | 142,396 | $30.1M |
| URGNUroGen Pharma Ltd. | 1,637,570 | $29.4M |
| VERAVera Therapeutics, Inc. | 728,330 | $29.3M |
| CYTKCYTOKINETICS INC | 443,957 | $29.3M |
| RGENREPLIGEN CORP | 235,365 | $27.7M |
| CNTACentessa Pharmaceuticals plc | 687,427 | $27.3M |
| CLDXCelldex Therapeutics, Inc. | 856,310 | $27.2M |
| RIOTRiot Platforms, Inc. | 2,148,272 | $26.6M |
| MLYSMineralys Therapeutics, Inc. | 884,107 | $24.0M |
| RDYDR REDDYS LABORATORIES LTD | 1,661,333 | $23.0M |
| PCVXVaxcyte, Inc. | 355,854 | $20.7M |
| EBSEmergent BioSolutions Inc. | 2,425,722 | $20.1M |
| AMPHAmphastar Pharmaceuticals, Inc. | 1,017,538 | $19.9M |
| NBIXNEUROCRINE BIOSCIENCES INC | 150,298 | $19.8M |
| BIIBBIOGEN INC. | 104,783 | $19.2M |
| PCRXPacira BioSciences, Inc. | 837,563 | $18.9M |
| DNLIDenali Therapeutics Inc. | 935,692 | $18.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 519,455 | $16.6M |
| GMEDGlobus Medical Inc. | 189,032 | $16.3M |
| ELVElevance Health Inc. | 52,670 | $15.4M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 460,744 | $15.2M |
| ANIPANI PHARMACEUTICALS INC | 191,576 | $14.7M |
| RIGLRIGEL PHARMACEUTICALS INC | 544,431 | $14.7M |
| NUSNu Skin Enterprises Inc. | 2,021,202 | $14.7M |
| GMABGenmab A/S | 538,944 | $14.5M |
| TEVATeva Pharmaceutical Industries Limited | 469,635 | $14.1M |
| NATRNATURES SUNSHINE PRODUCTS INC | 574,825 | $13.8M |
| HALOHALOZYME THERAPEUTICS, INC. | 208,091 | $13.4M |
| NUVBNuvation Bio Inc. | 2,897,078 | $12.4M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,916,346 | $12.2M |
| ACHCAcadia Healthcare Company Inc. | 518,606 | $12.1M |
| EVMNEvommune, Inc. | 492,938 | $11.3M |
| MEDPMedpace Holdings Inc. | 21,873 | $10.5M |
| TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock) | 515,359 | $9.5M |
| NEOGNEOGEN CORP | 977,678 | $9.1M |
| INDVIndivior Pharmaceuticals, Inc. | 273,434 | $8.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 161,025 | $8.3M |
| LGNDLigand Pharmaceuticals Incorporated | 40,495 | $8.1M |
| IDYAIDEAYA Biosciences, Inc. | 241,508 | $8.0M |
| SIGASIGA TECHNOLOGIES INC | 1,317,784 | $7.1M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 79,096 | $6.6M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 115,882 | $6.5M |
| ERASErasca, Inc. | 380,977 | $6.2M |
| PBHPrestige Consumer Healthcare Inc. | 101,903 | $6.0M |
| MMSIMerit Medical Systems Inc. | 85,661 | $5.9M |
| CRSPCRISPR Therapeutics AG | 120,488 | $5.7M |
| BVSBioventus Inc. | 619,803 | $5.7M |
| ALHCAlignment Healthcare Inc. | 312,851 | $5.5M |
| RPRXRoyalty Pharma plc | 113,636 | $5.5M |
| AUPHAurinia Pharmaceuticals Inc. | 365,236 | $5.4M |
| QGENQIAGEN N.V. | 123,079 | $4.9M |
| ELANElanco Animal Health Inc | 187,928 | $4.5M |
| ICUIICU Medical Inc. | 34,062 | $4.4M |
| RLAYRelay Therapeutics, Inc. | 440,185 | $4.4M |
| BNTXBioNTech SE | 47,643 | $4.2M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 120,253 | $4.1M |
| BEAMBeam Therapeutics Inc. | 168,673 | $4.0M |
| KURAKura Oncology, Inc. | 486,570 | $4.0M |
| MRNAModerna, Inc. | 76,687 | $3.9M |
| AVNSAvanos Medical Inc. | 274,921 | $3.9M |
| PGNYProgyny Inc. | 225,792 | $3.8M |
| ONCBeOne Medicines Ltd. | 12,346 | $3.7M |
| ORKAOruka Therapeutics, Inc. | 74,386 | $3.6M |
| SHCSotera Health Company | 251,852 | $3.6M |
| SPRYARS Pharmaceuticals, Inc. | 428,599 | $3.4M |
| USNAUSANA HEALTH SCIENCES INC | 190,952 | $3.3M |
| ROIVRoivant Sciences Ltd. | 114,627 | $3.2M |
| OGNOrganon & Co. | 477,736 | $2.9M |
| MOHMolina Healthcare Inc | 20,068 | $2.7M |
| NTLAIntellia Therapeutics, Inc. | 208,301 | $2.7M |
| VIRVir Biotechnology, Inc. | 296,824 | $2.7M |
| ELVNEnliven Therapeutics, Inc. | 62,116 | $2.4M |
| ALMSALUMIS INC. | 102,456 | $2.3M |
| PMPhilip Morris International Inc | 13,030 | $2.2M |
| XNCRXencor Inc | 175,177 | $2.1M |
| SRPTSarepta Therapeutics, Inc. | 94,400 | $2.1M |
| CGEMCullinan Therapeutics, Inc. | 144,107 | $2.0M |
| ANIKAnika Therapeutics Inc. | 137,584 | $2.0M |
| CSTLCastle Biosciences Inc. | 79,107 | $1.9M |
| TBPHTheravance Biopharma, Inc. | 117,738 | $1.9M |
| DAWNDay One Biopharmaceuticals, Inc. | 88,278 | $1.9M |
| ORICOric Pharmaceuticals, Inc. | 146,804 | $1.9M |
| TYRATyra Biosciences, Inc. | 47,929 | $1.8M |
| TWSTTwist Bioscience Corp | 37,838 | $1.8M |
| ZYMEZymeworks Inc. | 70,851 | $1.8M |
| ACADACADIA PHARMACEUTICALS INC | 79,266 | $1.8M |
| RAPPRapport Therapeutics, Inc. | 56,292 | $1.8M |
| CRLCHARLES RIVER LABORATORIES INTERNATIONAL, INC. | 9,148 | $1.6M |
| MDXGMiMedx Group Inc | 382,824 | $1.5M |
| SEPNSepterna, Inc. | 61,290 | $1.5M |
| BAXBaxter International Inc. | 84,521 | $1.4M |
| PRGOPERRIGO Co plc | 117,052 | $1.3M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 355,806 | $1.2M |
| OLMAOlema Pharmaceuticals, Inc. | 81,734 | $1.2M |
| NRIXNurix Therapeutics, Inc. | 78,057 | $1.2M |
| FULCFulcrum Therapeutics, Inc. | 156,242 | $1.2M |
| GLPGGalapagos NV | 38,790 | $1.2M |
| BCAXBicara Therapeutics Inc. | 51,553 | $1.0M |
| OFIXOrthofix Medical Inc. Common Stock (DE) | 87,822 | $1.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 69,479 | $1.0M |
| TRDAEntrada Therapeutics, Inc. | 77,971 | $984K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 310,434 | $953K |
| FDMT4D Molecular Therapeutics, Inc. | 101,511 | $945K |
| NEONeoGenomics Inc. | 127,243 | $944K |
| CYRXCryoport, Inc. | 112,353 | $930K |
| ARVNARVINAS, INC. | 85,492 | $906K |
| AVIRAtea Pharmaceuticals, Inc. | 167,230 | $900K |
| FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share) | 38,613 | $871K |
| FLGTFulgent Genetics Inc. | 53,941 | $858K |
| BHCBausch Health Companies Inc. | 157,050 | $849K |
| SLDBSolid Biosciences Inc. | 114,392 | $824K |
| UPBUpstream Bio, Inc. | 87,624 | $789K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 79,631 | $774K |
| STOKStoke Therapeutics, Inc. | 23,397 | $762K |
| KROSKeros Therapeutics, Inc. | 64,260 | $709K |
| TVTXTravere Therapeutics, Inc. | 23,814 | $708K |
| KRYSKrystal Biotech, Inc. | 2,717 | $702K |
| DSGNDesign Therapeutics, Inc. | 65,638 | $698K |
| PAHCPHIBRO ANIMAL HEALTH CORP | 12,282 | $679K |
| NRCNational Research Corporation Common Stock (Delaware) | 38,468 | $653K |
| DVADaVita Inc. | 4,003 | $615K |
| AKBAAkebia Therapeutics, Inc. | 415,988 | $578K |
| VYGRVoyager Therapeutics, Inc. | 147,647 | $570K |
| ABSIAbsci Corporation | 185,869 | $558K |
| MCRBSeres Therapeutics, Inc. | 62,316 | $553K |
| INSPInspire Medical Systems Inc. | 10,682 | $551K |
| ARRYARRAY BIOPHARMA INC | 75,614 | $547K |
| DNAGinkgo Bioworks Holdings Inc. | 87,386 | $536K |
| ARCTArcturus Therapeutics Holdings Inc. | 66,012 | $510K |
| BIOABioAge Labs, Inc. | 28,903 | $506K |
| TARAProtara Therapeutics, Inc. | 92,969 | $484K |
| JBIOJade Biosciences, Inc. | 33,369 | $469K |
| KYTXKyverna Therapeutics, Inc. | 53,235 | $459K |
| RAREUltragenyx Pharmaceutical Inc. | 21,780 | $456K |
| LFVNLifevantage Corp | 104,664 | $452K |
| AVBPArriVent BioPharma, Inc. | 19,515 | $450K |
| UTMDUtah Medical Products Inc. | 7,253 | $450K |
| ACRSAclaris Therapeutics, Inc. | 118,702 | $445K |
| JANXJanux Therapeutics, Inc. | 30,215 | $420K |
| CMPXCompass Therapeutics, Inc. | 78,328 | $414K |
| ORGOOrganogenesis Holdings Inc. | 168,372 | $399K |
| KODKodiak Sciences Inc. | 10,356 | $395K |
| TECXTectonic Therapeutic, Inc. | 12,534 | $387K |
| MYGNMYRIAD GENETICS INC | 85,615 | $385K |
| ABCLAbCellera Biologics Inc. | 109,011 | $380K |
| NGNENeurogene Inc. | 18,540 | $374K |
| KNSAKiniksa Pharmaceuticals International, plc | 7,302 | $352K |
| LRMRLarimar Therapeutics, Inc. | 77,636 | $349K |
| PTCTPTC THERAPEUTICS, INC. | 5,003 | $341K |
| CGONCG Oncology, Inc. | 4,907 | $332K |
| FBRXForte Biosciences, Inc. | 12,699 | $329K |
| NAGENiagen Bioscience, Inc. | 74,490 | $329K |
| AURAAura Biosciences, Inc. | 48,323 | $323K |
| LYELLyell Immunopharma, Inc. | 15,971 | $320K |
| ANROAlto Neuroscience, Inc. | 14,186 | $319K |
| SGMTSagimet Biosciences Inc. | 60,369 | $315K |
| ETONEton Pharmaceuticals, Inc. | 11,926 | $294K |
| CABACabaletta Bio, Inc. | 108,319 | $291K |
| MAZEMaze Therapeutics, Inc. | 9,635 | $288K |
| CAICaris Life Sciences Inc. | 14,940 | $267K |
| IMNMImmunome Inc. | 12,149 | $266K |
| MBXMBX Biosciences, Inc. | 8,726 | $260K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 9,154 | $254K |
| BBNXBeta Bionics Inc. | 23,904 | $240K |
| CCCCC4 Therapeutics, Inc. | 85,444 | $225K |
| CRBUCaribou Biosciences, Inc. | 112,453 | $214K |
| RCKTRocket Pharmaceuticals Inc. | 57,562 | $206K |
| ZURAZura Bio Ltd | 33,733 | $201K |
| NKTXNkarta, Inc. | 94,851 | $200K |
| BDTXBlack Diamond Therapeutics, Inc. | 91,046 | $194K |
| ALTAltimmune, Inc. | 62,909 | $194K |
| HLFHerbalife Ltd. | 13,019 | $192K |
| IMRXImmuneering Corp | 34,224 | $180K |
| CRMDCorMedix Inc. | 26,402 | $179K |
| TNXPTonix Pharmaceuticals Holding Corp. | 12,850 | $177K |
| CATXPerspective Therapeutics, Inc. | 35,722 | $149K |
| SABSSAB BIOTHERAPEUTICS, INC. | 37,455 | $143K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 15,139 | $142K |
| CNTXContext Therapeutics Inc. | 50,912 | $133K |
| IPSCCentury Therapeutics, Inc. | 58,742 | $133K |
| ALLOAllogene Therapeutics, Inc. | 50,228 | $123K |
| INNVINNOVUS PHARMACEUTICALS, INC. | 15,109 | $121K |
| QTTBQ32 Bio Inc. | 18,770 | $121K |
| ZNTLZentalis Pharmaceuticals, Inc. | 48,572 | $114K |
| ORMPORAMED PHARMACEUTICALS INC. | 32,307 | $110K |
| BHVNBiohaven Ltd. | 11,368 | $96K |
| FLNAFilana Therapeutics Inc. | 53,367 | $90K |
| REPLReplimune Group, Inc. | 11,650 | $89K |
| MGNXMACROGENICS INC | 30,556 | $88K |
| SRTSSensus Healthcare Inc. | 21,272 | $85K |
| PEPGPepGen Inc. | 42,601 | $75K |
| CHRSCoherus Oncology, Inc. | 43,242 | $73K |
| ANNXAnnexon, Inc. | 12,463 | $69K |
| ABEOABEONA THERAPEUTICS INC. | 12,718 | $57K |
| OABIOmniAb Inc. | 34,816 | $55K |
| ABOSAcumen Pharmaceuticals, Inc. | 17,929 | $42K |
| PRLDPrelude Therapeutics Inc | 10,294 | $35K |
| MBOTMicrobot Medical Inc. | 12,418 | $30K |