| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 11,797,085 | $651K |
| INCYIncyte Corp. | 1,900,824 | $179K |
| REGNREGENERON PHARMACEUTICALS, INC. | 151,191 | $117K |
| KNSAKiniksa Pharmaceuticals International, plc | 1,336,313 | $64K |
| GILDGILEAD SCIENCES, INC. | 267,646 | $37K |
| RDYDR REDDYS LABORATORIES LTD | 2,408,761 | $33K |
| FLGTFulgent Genetics Inc. | 1,233,951 | $20K |
| IMCRImmunocore Holdings plc | 501,091 | $15K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 1,547,593 | $15K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 2,041,759 | $13K |
| TEVATeva Pharmaceutical Industries Limited | 397,716 | $12K |
| JAZZJazz Pharmaceuticals plc | 54,814 | $10K |
| ARVNARVINAS, INC. | 949,874 | $10K |
| BCYCBICYCLE THERAPEUTICS PLC | 1,968,025 | $9K |
| ALECAlector, Inc. | 4,038,785 | $9K |
| STROSUTRO BIOPHARMA, INC. | 335,813 | $8K |
| BIOABioAge Labs, Inc. | 392,346 | $7K |
| ZNTLZentalis Pharmaceuticals, Inc. | 2,848,252 | $7K |
| DSGNDesign Therapeutics, Inc. | 616,481 | $7K |
| BDTXBlack Diamond Therapeutics, Inc. | 2,348,651 | $5K |
| CCCCC4 Therapeutics, Inc. | 1,890,914 | $5K |
| RLMDRELMADA THERAPEUTICS, INC. | 712,540 | $5K |
| FATEFATE THERAPEUTICS INC | 4,120,200 | $5K |
| TRDAEntrada Therapeutics, Inc. | 333,169 | $4K |
| ANNXAnnexon, Inc. | 758,232 | $4K |
| ORGOOrganogenesis Holdings Inc. | 1,576,645 | $4K |
| EXELEXELIXIS, INC. | 81,718 | $3K |
| PLRXPLIANT THERAPEUTICS, INC. | 2,416,508 | $3K |
| APLSApellis Pharmaceuticals, Inc. | 74,716 | $3K |
| KURAKura Oncology, Inc. | 365,118 | $3K |
| PTCTPTC THERAPEUTICS, INC. | 32,735 | $2K |
| ALXOALX ONCOLOGY HOLDINGS INC | 1,101,025 | $2K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 38,356 | $2K |
| PRLDPrelude Therapeutics Inc | 511,519 | $2K |
| BBIOBridgeBio Pharma, Inc. | 20,768 | $2K |
| ALDXAldeyra Therapeutics, Inc. | 858,288 | $1K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 20,535 | $1K |
| KZRKezar Life Sciences, Inc. | 151,630 | $1K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 108,792 | $1K |
| SIGASIGA TECHNOLOGIES INC | 188,484 | $1K |
| VYGRVoyager Therapeutics, Inc. | 248,871 | $957 |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 18,131 | $934 |
| ACETAdicet Bio, Inc. | 118,138 | $802 |
| ANABANAPTYSBIO, INC | 13,219 | $730 |
| KROSKeros Therapeutics, Inc. | 65,436 | $721 |
| KYNBKYNTRA BIO INC. | 105,585 | $714 |
| AGENAGENUS INC | 215,047 | $713 |
| LXRXLEXICON PHARMACEUTICALS, INC. | 445,288 | $693 |
| BHVNBiohaven Ltd. | 81,748 | $688 |
| ARDXARDELYX, INC. | 115,334 | $687 |
| MRNAModerna, Inc. | 13,380 | $677 |
| ACADACADIA PHARMACEUTICALS INC | 29,722 | $660 |
| ATNMActinium Pharmaceuticals, Inc. | 600,819 | $596 |
| COGTCogent Biosciences, Inc. | 13,814 | $530 |
| FLNAFilana Therapeutics Inc. | 284,213 | $478 |
| KRROKorro Bio, Inc. | 41,825 | $471 |
| OGNOrganon & Co. | 75,233 | $449 |
| AXSMAxsome Therapeutics, Inc. | 2,427 | $410 |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 513,168 | $409 |
| ESPREsperion Therapeutics, Inc. | 125,942 | $343 |
| VTGNVistagen Therapeutics, Inc. | 589,663 | $336 |
| MLTXMoonLake Immunotherapeutics | 16,527 | $305 |
| CTMXCytomX Therapeutics, Inc. | 63,694 | $298 |
| TGTXTG THERAPEUTICS, INC. | 8,660 | $287 |
| STOKStoke Therapeutics, Inc. | 8,759 | $284 |
| DNAGinkgo Bioworks Holdings Inc. | 46,171 | $281 |
| ACIUAC Immune SA | 96,907 | $266 |
| LRMRLarimar Therapeutics, Inc. | 59,481 | $265 |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 29,148 | $260 |
| WHWKWhitehawk Therapeutics, Inc. | 70,101 | $239 |
| INVAInnoviva, Inc. | 10,249 | $237 |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 621 | $205 |
| CHRSCoherus Oncology, Inc. | 117,866 | $198 |
| BCABBioAtla, Inc. | 1,233,919 | $198 |
| AGIOAGIOS PHARMACEUTICALS, INC. | 5,859 | $196 |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 2,218 | $192 |
| LENZLENZ Therapeutics, Inc. | 20,611 | $188 |
| FDMT4D Molecular Therapeutics, Inc. | 20,109 | $186 |
| ADPTAdaptive Biotechnologies Corp | 12,807 | $177 |
| ONCBeOne Medicines Ltd. | 597 | $177 |
| QNCXQuince Therapeutics, Inc. | 1,750,862 | $176 |
| SGMTSagimet Biosciences Inc. | 29,636 | $154 |
| ARQTArcutis Biotherapeutics, Inc. | 6,333 | $149 |
| RNACCartesian Therapeutics, Inc. | 23,484 | $142 |
| NKTRNEKTAR THERAPEUTICS | 1,989 | $141 |
| CSBRCHAMPIONS ONCOLOGY, INC. | 21,323 | $121 |
| LONALeonaBio, Inc. | 10,230 | $105 |
| RZLTRezolute, Inc. | 33,769 | $101 |
| RCUSArcus Biosciences, Inc. | 4,350 | $93 |
| RLYBRallybio Corp | 10,433 | $92 |
| BEAMBeam Therapeutics Inc. | 3,348 | $79 |
| TVTXTravere Therapeutics, Inc. | 2,624 | $77 |
| ASRTAssertio Holdings, Inc. | 3,899 | $73 |
| TENXTENAX THERAPEUTICS, INC. | 4,502 | $71 |
| PCVXVaxcyte, Inc. | 1,072 | $62 |
| ORMPORAMED PHARMACEUTICALS INC. | 15,066 | $50 |
| SRZNSurrozen Inc. | 1,508 | $43 |
| INSMINSMED Inc | 240 | $39 |
| AUTLAutolus Therapeutics plc | 27,597 | $38 |
| ORICOric Pharmaceuticals, Inc. | 2,679 | $33 |
| ANIXAnixa Biosciences Inc | 12,898 | $33 |
| NTLAIntellia Therapeutics, Inc. | 2,607 | $32 |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 8,417 | $29 |
| RGNXREGENXBIO Inc. | 3,233 | $27 |
| AYTUAYTU BIOPHARMA, INC | 10,237 | $27 |
| SLNSilence Therapeutics Plc | 4,818 | $25 |
| MISTMilestone Pharmaceuticals Inc. | 20,468 | $24 |
| ALTAltimmune, Inc. | 7,311 | $22 |
| VCELVericel Corp | 675 | $21 |
| IVVDInvivyd, Inc. | 13,022 | $16 |
| ALMSALUMIS INC. | 588 | $12 |
| OLMAOlema Pharmaceuticals, Inc. | 721 | $10 |
| ATHEAlterity Therapeutics Limited | 1,863 | $6 |
| TERNTerns Pharmaceuticals, Inc. | 98 | $5 |
| XFORX4 Pharmaceuticals, Inc | 802 | $3 |
| HURATuHURA Biosciences, Inc./NV | 20 | $0 |
| RNTXRein Therapeutics, Inc. | 17 | $0 |
| HCMHUTCHMED (China) Limited | 9 | $0 |
| NCNANuCana plc | 2 | $0 |