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| MRKMerck & Co., Inc. | 84,314,971 | $10.14B |
| JNJJOHNSON & JOHNSON | 20,075,375 | $4.91B |
| AZNASTRAZENECA PLC | 23,751,085 | $4.63B |
| PMPhilip Morris International Inc | 16,855,584 | $2.79B |
| ABTABBOTT LABORATORIES | 27,070,518 | $2.78B |
| UNHUnitedHealth Group Incorporated Common Stock (DE) | 10,091,639 | $2.73B |
| ELVElevance Health Inc. | 8,228,537 | $2.41B |
| GILDGILEAD SCIENCES, INC. | 13,537,991 | $1.89B |
| ABBVAbbVie Inc. | 6,897,816 | $1.50B |
| VRTXVERTEX PHARMACEUTICALS INC / MA | 3,212,589 | $1.43B |
| CORCencora Inc. | 4,548,612 | $1.43B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,837,459 | $1.42B |
| PFEPFIZER INC | 49,916,961 | $1.40B |
| UTHRUNITED THERAPEUTICS Corp | 2,264,247 | $1.34B |
| ZTSZoetis Inc. | 10,150,096 | $1.20B |
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| ICLRICON plc | 5,913,037 | $654.3M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 11,717,613 | $646.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,935,925 | $640.5M |
| RVMDREVOLUTION MEDICINES, INC. | 6,027,819 | $586.2M |
| QGENQIAGEN N.V. | 14,364,303 | $575.1M |
| BIIBBIOGEN INC. | 2,961,641 | $543.0M |
| CYTKCYTOKINETICS INC | 8,009,489 | $527.9M |
| IONSIONIS PHARMACEUTICALS INC | 6,391,816 | $480.0M |
| IDXXIDEXX LABORATORIES INC /DE | 735,475 | $413.3M |
| PTGXProtagonist Therapeutics, Inc | 3,599,644 | $379.4M |
| APGEApogee Therapeutics, Inc. | 4,375,703 | $368.3M |
| MDGLMADRIGAL PHARMACEUTICALS, INC. | 694,958 | $363.8M |
| CGONCG Oncology, Inc. | 5,371,232 | $363.5M |
| GPCRStructure Therapeutics Inc. | 7,260,287 | $349.9M |
| BMYBRISTOL MYERS SQUIBB CO | 5,506,996 | $334.0M |
| SRRKScholar Rock Holding Corp | 6,717,655 | $330.2M |
| PCVXVaxcyte, Inc. | 5,614,597 | $326.3M |
| KYMRKymera Therapeutics, Inc. | 3,889,687 | $324.0M |
| INCYIncyte Corp. | 3,266,136 | $307.4M |
| ALHCAlignment Healthcare Inc. | 17,098,936 | $301.3M |
| CRNXCrinetics Pharmaceuticals, Inc. | 8,157,204 | $296.3M |
| CRLCHARLES RIVER LABORATORIES INTERNATIONAL, INC. | 1,629,401 | $281.1M |
| XENEXenon Pharmaceuticals Inc. | 4,829,641 | $280.8M |
| CLDXCelldex Therapeutics, Inc. | 8,560,476 | $271.5M |
| PTCTPTC THERAPEUTICS, INC. | 3,942,610 | $268.6M |
| TECHBIO-TECHNE Corp | 5,120,185 | $267.6M |
| NUVLNuvalent, Inc. | 2,470,491 | $253.1M |
| TEVATeva Pharmaceutical Industries Limited | 7,251,828 | $218.4M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 2,595,783 | $217.8M |
| ACHCAcadia Healthcare Company Inc. | 9,072,942 | $212.2M |
| AXSMAxsome Therapeutics, Inc. | 1,145,306 | $193.6M |
| BBIOBridgeBio Pharma, Inc. | 2,483,953 | $184.5M |
| NBIXNEUROCRINE BIOSCIENCES INC | 1,389,539 | $183.1M |
| GMOptec International, Inc. | 2,386,253 | $177.8M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 5,115,818 | $163.8M |
| MOHMolina Healthcare Inc | 1,131,960 | $150.9M |
| SLNOSOLENO THERAPEUTICS INC | 4,426,781 | $148.2M |
| IMCRImmunocore Holdings plc | 4,706,168 | $141.9M |
| COGTCogent Biosciences, Inc. | 3,578,622 | $137.7M |
| RCUSArcus Biosciences, Inc. | 6,089,516 | $131.5M |
| INSPInspire Medical Systems Inc. | 2,535,954 | $130.8M |
| MIRMMirum Pharmaceuticals, Inc. | 1,334,809 | $123.3M |
| MRNAModerna, Inc. | 2,357,597 | $119.8M |
| IRONDisc Medicine, Inc. | 1,735,376 | $111.0M |
| ALKSAlkermes plc. | 2,970,166 | $105.0M |
| IMNMImmunome Inc. | 4,731,977 | $103.5M |
| STOKStoke Therapeutics, Inc. | 3,095,700 | $100.8M |
| MBXMBX Biosciences, Inc. | 3,191,824 | $95.3M |
| SYRESpyre Therapeutics, Inc. | 1,824,811 | $92.0M |
| MLYSMineralys Therapeutics, Inc. | 3,359,068 | $91.0M |
| GHGuardant Health Inc. | 972,563 | $89.8M |
| JAZZJazz Pharmaceuticals plc | 458,014 | $86.6M |
| AMGNAMGEN INC | 228,017 | $80.2M |
| ELANElanco Animal Health Inc | 3,035,856 | $72.6M |
| INSMINSMED Inc | 399,044 | $65.3M |
| WSTWest Pharmaceutical Services Inc. | 248,636 | $62.3M |
| TRVITrevi Therapeutics, Inc. | 5,189,088 | $61.9M |
| VRDNViridian Therapeutics, Inc.\DE | 3,078,554 | $60.2M |
| PHVSPharvaris N.V. | 2,118,900 | $59.9M |
| LNTHLantheus Holdings, Inc. | 768,850 | $58.3M |
| PRAXPraxis Precision Medicines, Inc. | 174,350 | $56.2M |
| RAREUltragenyx Pharmaceutical Inc. | 2,640,812 | $55.3M |
| ADPTAdaptive Biotechnologies Corp | 3,857,422 | $53.5M |
| ARRYARRAY BIOPHARMA INC | 5,782,216 | $41.8M |
| AKTSAktis Oncology Inc. | 2,317,044 | $41.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 716,523 | $40.5M |
| PGNYProgyny Inc. | 2,287,381 | $38.8M |
| OCSOculis Holding AG | 1,345,728 | $35.8M |
| MCKMcKesson Corporation | 40,624 | $35.2M |
| TWSTTwist Bioscience Corp | 738,629 | $35.1M |
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| ICUIICU Medical Inc. | 243,121 | $31.4M |
| TVTXTravere Therapeutics, Inc. | 1,022,272 | $30.4M |
| MANEVeradermics Incorporated | 477,833 | $30.2M |
| DMRADamora Therapeutics, Inc. | 1,058,000 | $27.4M |
| ROIVRoivant Sciences Ltd. | 963,282 | $26.7M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 2,818,348 | $25.2M |
| DFTXDefinium Therapeutics Inc. | 1,304,749 | $24.7M |
| ZBIOZenas BioPharma, Inc. | 1,246,053 | $24.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 273,757 | $23.8M |
| MEDPMedpace Holdings Inc. | 48,222 | $23.2M |
| JANXJanux Therapeutics, Inc. | 1,597,650 | $22.2M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 641,486 | $21.7M |
| PRCTPROCEPT BioRobotics Corporation | 861,605 | $21.5M |
| MMSIMerit Medical Systems Inc. | 303,828 | $20.9M |
| RIOTRiot Platforms, Inc. | 1,618,318 | $20.0M |
| TERNTerns Pharmaceuticals, Inc. | 375,505 | $19.8M |
| DGXQuest Diagnostics Incorporated | 90,736 | $17.8M |
| CTMXCytomX Therapeutics, Inc. | 3,582,985 | $16.8M |
| KODKodiak Sciences Inc. | 436,329 | $16.6M |
| IMTXImmatics N.V. | 1,561,892 | $15.4M |
| SVRASavara Inc | 2,710,723 | $14.8M |
| TRDAEntrada Therapeutics, Inc. | 1,034,782 | $13.1M |
| XERSXeris Biopharma Holdings, Inc. | 2,171,354 | $12.6M |
| IQVIQVIA Holdings Inc. | 72,874 | $12.4M |
| BNTXBioNTech SE | 135,018 | $12.0M |
| PCRXPacira BioSciences, Inc. | 478,383 | $10.8M |
| APLSApellis Pharmaceuticals, Inc. | 249,635 | $10.0M |
| DRUGBRIGHT MINDS BIOSCIENCES INC. | 136,677 | $10.0M |
| OLMAOlema Pharmaceuticals, Inc. | 664,679 | $9.9M |
| ERASErasca, Inc. | 595,379 | $9.6M |
| MNPRMonopar Therapeutics | 174,342 | $9.6M |
| PMNProMIS Neurosciences Inc. | 696,378 | $8.8M |
| VCELVericel Corp | 272,777 | $8.8M |
| MNKDMANNKIND CORP | 3,283,179 | $8.0M |
| LQDALiquidia Corp | 199,060 | $7.5M |
| GEHCGE HealthCare Technologies Inc. | 102,107 | $7.3M |
| SMMTSummit Therapeutics Inc. | 362,858 | $6.9M |
| ONCBeOne Medicines Ltd. | 20,828 | $6.2M |
| TNGXTango Therapeutics, Inc. | 289,180 | $6.0M |
| ORKAOruka Therapeutics, Inc. | 121,225 | $5.9M |
| ELVNEnliven Therapeutics, Inc. | 150,126 | $5.9M |
| ALMSALUMIS INC. | 239,231 | $5.3M |
| PALIPALISADE BIO, INC. | 2,904,911 | $5.1M |
| NRIXNurix Therapeutics, Inc. | 321,360 | $5.0M |
| PVLAPALVELLA THERAPEUTICS, INC. | 34,040 | $4.2M |
| OSCROscar Health Inc. | 364,566 | $4.2M |
| ZBHZimmer Biomet Holdings Inc. | 44,360 | $4.0M |
| ZYMEZymeworks Inc. | 138,690 | $3.5M |
| COLLCOLLEGIUM PHARMACEUTICAL, INC | 103,485 | $3.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 54,518 | $3.4M |
| AMLXAmylyx Pharmaceuticals, Inc. | 241,552 | $3.4M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 108,604 | $3.3M |
| PAHCPHIBRO ANIMAL HEALTH CORP | 58,010 | $3.2M |
| SPRBSPRUCE BIOSCIENCES, INC. | 48,796 | $3.2M |
| UPBUpstream Bio, Inc. | 342,353 | $3.1M |
| TYRATyra Biosciences, Inc. | 77,169 | $3.0M |
| ANNXAnnexon, Inc. | 521,379 | $2.9M |
| SNDXSyndax Pharmaceuticals Inc | 123,586 | $2.9M |
| NUVBNuvation Bio Inc. | 672,144 | $2.9M |
| TSHATaysha Gene Therapies, Inc. | 626,361 | $2.8M |
| WVEWave Life Sciences Ltd. | 373,794 | $2.7M |
| KRYSKrystal Biotech, Inc. | 10,227 | $2.6M |
| GMEDGlobus Medical Inc. | 30,215 | $2.6M |
| ANABANAPTYSBIO, INC | 46,881 | $2.6M |
| RAPPRapport Therapeutics, Inc. | 78,231 | $2.4M |
| VERAVera Therapeutics, Inc. | 59,856 | $2.4M |
| RDYDR REDDYS LABORATORIES LTD | 170,576 | $2.4M |
| ORICOric Pharmaceuticals, Inc. | 186,099 | $2.4M |
| KALVKalVista Pharmaceuticals, Inc. | 107,262 | $2.2M |
| CGEMCullinan Therapeutics, Inc. | 149,626 | $2.1M |
| GLUEMonte Rosa Therapeutics, Inc. | 128,792 | $2.1M |
| TGTXTG THERAPEUTICS, INC. | 59,965 | $2.0M |
| ABUSArbutus Biopharma Corp | 440,924 | $2.0M |
| OMEROMEROS CORP | 187,300 | $2.0M |
| PGENPRECIGEN, INC. | 508,434 | $2.0M |
| EIKNEikon Therapeutics Inc. | 185,000 | $2.0M |
| ESPREsperion Therapeutics, Inc. | 695,848 | $1.9M |
| CMPXCompass Therapeutics, Inc. | 360,125 | $1.9M |
| SIONSionna Therapeutics, Inc. | 46,079 | $1.8M |
| JBIOJade Biosciences, Inc. | 129,166 | $1.8M |
| MAZEMaze Therapeutics, Inc. | 60,587 | $1.8M |
| AVBPArriVent BioPharma, Inc. | 78,213 | $1.8M |
| URGNUroGen Pharma Ltd. | 100,215 | $1.8M |
| TBPHTheravance Biopharma, Inc. | 109,700 | $1.8M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 81,252 | $1.8M |
| INBXInhibrx Biosciences, Inc. | 25,785 | $1.7M |
| ETONEton Pharmaceuticals, Inc. | 70,124 | $1.7M |
| CRSPCRISPR Therapeutics AG | 34,869 | $1.7M |
| IRWDIRONWOOD PHARMACEUTICALS INC | 453,515 | $1.6M |
| LGNDLigand Pharmaceuticals Incorporated | 7,906 | $1.6M |
| RIGLRIGEL PHARMACEUTICALS INC | 56,502 | $1.5M |
| REPLReplimune Group, Inc. | 197,578 | $1.5M |
| INDVIndivior Pharmaceuticals, Inc. | 49,129 | $1.5M |
| SLSSELLAS Life Sciences Group, Inc. | 344,778 | $1.5M |
| ZVRAZEVRA THERAPEUTICS, INC. | 156,417 | $1.5M |
| BVSBioventus Inc. | 154,141 | $1.4M |
| CRMDCorMedix Inc. | 204,265 | $1.4M |
| ANROAlto Neuroscience, Inc. | 59,799 | $1.3M |
| MDXGMiMedx Group Inc | 336,098 | $1.3M |
| LBRXLB PHARMACEUTICALS INC | 52,640 | $1.3M |
| EBSEmergent BioSolutions Inc. | 151,246 | $1.3M |
| ARTVArtiva Biotherapeutics, Inc. | 194,108 | $1.3M |
| PHATPhathom Pharmaceuticals, Inc. | 111,752 | $1.2M |
| ACRVAcrivon Therapeutics, Inc. | 888,130 | $1.2M |
| PBHPrestige Consumer Healthcare Inc. | 20,524 | $1.2M |
| AQSTAquestive Therapeutics, Inc. | 290,060 | $1.2M |
| BIOABioAge Labs, Inc. | 67,681 | $1.2M |
| SLDBSolid Biosciences Inc. | 161,278 | $1.2M |
| CPRXCATALYST PHARMACEUTICALS, INC. | 46,817 | $1.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 21,861 | $1.1M |
| TARSTarsus Pharmaceuticals, Inc. | 16,085 | $1.1M |
| ACADACADIA PHARMACEUTICALS INC | 49,981 | $1.1M |
| ABSIAbsci Corporation | 366,808 | $1.1M |
| IDYAIDEAYA Biosciences, Inc. | 32,851 | $1.1M |
| MGTXMeiraGTx Holdings plc | 126,331 | $1.1M |
| ARQTArcutis Biotherapeutics, Inc. | 44,373 | $1.0M |
| IBRXImmunityBio, Inc. | 133,855 | $1.0M |
| DNLIDenali Therapeutics Inc. | 53,363 | $1.0M |
| FDMT4D Molecular Therapeutics, Inc. | 108,872 | $1.0M |
| OGNOrganon & Co. | 167,327 | $1.0M |
| AKBAAkebia Therapeutics, Inc. | 707,745 | $984K |
| PRMEPrime Medicine, Inc. | 278,120 | $968K |
| ACRSAclaris Therapeutics, Inc. | 257,156 | $964K |
| ENTAENANTA PHARMACEUTICALS INC | 74,960 | $947K |
| BCRXBIOCRYST PHARMACEUTICALS INC | 98,883 | $941K |
| MPLTMapLight Therapeutics, Inc. | 46,208 | $939K |
| BEAMBeam Therapeutics Inc. | 38,824 | $925K |
| FULCFulcrum Therapeutics, Inc. | 118,600 | $910K |
| TECXTectonic Therapeutic, Inc. | 29,240 | $904K |
| DYNDyne Therapeutics, Inc. | 48,882 | $886K |
| ADCTADC Therapeutics SA | 231,064 | $866K |
| EWTXEdgewise Therapeutics, Inc. | 27,409 | $863K |
| ADMAADMA BIOLOGICS, INC. | 95,213 | $858K |
| AURAAura Biosciences, Inc. | 127,543 | $853K |
| IMRXImmuneering Corp | 156,424 | $824K |
| VSTMVerastem, Inc. | 151,240 | $802K |
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| FBRXForte Biosciences, Inc. | 29,491 | $764K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 26,496 | $735K |
| IMVTImmunovant, Inc. | 28,525 | $709K |
| CATXPerspective Therapeutics, Inc. | 168,223 | $701K |
| AUPHAurinia Pharmaceuticals Inc. | 46,912 | $695K |
| ZURAZura Bio Ltd | 116,686 | $694K |
| AVXLANAVEX LIFE SCIENCES CORP. | 219,090 | $673K |
| CABACabaletta Bio, Inc. | 247,659 | $666K |
| HALOHALOZYME THERAPEUTICS, INC. | 10,288 | $665K |
| OCULOCULAR THERAPEUTIX, INC | 75,358 | $638K |
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| BAXBaxter International Inc. | 36,525 | $614K |
| BOLDBoundless Bio, Inc. | 556,233 | $612K |
| INVAInnoviva, Inc. | 25,454 | $593K |
| RLAYRelay Therapeutics, Inc. | 59,508 | $592K |
| ANIPANI PHARMACEUTICALS INC | 7,543 | $580K |
| ARDXARDELYX, INC. | 95,184 | $570K |
| NTLAIntellia Therapeutics, Inc. | 42,359 | $543K |
| NVAXNOVAVAX INC | 59,954 | $488K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 151,419 | $465K |
| DVADaVita Inc. | 2,372 | $365K |
| RPRXRoyalty Pharma plc | 7,131 | $342K |
| AVIRAtea Pharmaceuticals, Inc. | 57,009 | $307K |
| ALDXAldeyra Therapeutics, Inc. | 148,962 | $252K |
| PEPGPepGen Inc. | 121,974 | $216K |