| GILDGILEAD SCIENCES, INC. | 13,537,991 | $1.89B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,837,459 | $1.42B |
| ARGXARGENX SE | 1,021,457 | $745.9M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 11,717,613 | $646.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 1,935,925 | $640.5M |
| RVMDREVOLUTION MEDICINES, INC. | 6,027,819 | $586.2M |
| CYTKCYTOKINETICS INC | 8,009,489 | $527.9M |
| IONSIONIS PHARMACEUTICALS INC | 6,391,816 | $480.0M |
| PTGXProtagonist Therapeutics, Inc | 3,599,644 | $379.4M |
| APGEApogee Therapeutics, Inc. | 4,375,703 | $368.3M |
| GPCRStructure Therapeutics Inc. | 7,260,287 | $349.9M |
| SRRKScholar Rock Holding Corp | 6,717,655 | $330.2M |
| PCVXVaxcyte, Inc. | 5,614,597 | $326.3M |
| INCYIncyte Corp. | 3,266,136 | $307.4M |
| CLDXCelldex Therapeutics, Inc. | 8,560,476 | $271.5M |
| PTCTPTC THERAPEUTICS, INC. | 3,942,610 | $268.6M |
| NUVLNuvalent, Inc. | 2,470,491 | $253.1M |
| TEVATeva Pharmaceutical Industries Limited | 7,251,828 | $218.4M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 2,595,783 | $217.8M |
| AXSMAxsome Therapeutics, Inc. | 1,145,306 | $193.6M |
| BBIOBridgeBio Pharma, Inc. | 2,483,953 | $184.5M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 5,115,818 | $163.8M |
| SLNOSOLENO THERAPEUTICS INC | 4,426,781 | $148.2M |
| IMCRImmunocore Holdings plc | 4,706,168 | $141.9M |
| COGTCogent Biosciences, Inc. | 3,578,622 | $137.7M |
| RCUSArcus Biosciences, Inc. | 6,089,516 | $131.5M |
| MRNAModerna, Inc. | 2,357,597 | $119.8M |
| IRONDisc Medicine, Inc. | 1,735,376 | $111.0M |
| STOKStoke Therapeutics, Inc. | 3,095,700 | $100.8M |
| SYRESpyre Therapeutics, Inc. | 1,824,811 | $92.0M |
| JAZZJazz Pharmaceuticals plc | 458,014 | $86.6M |
| INSMINSMED Inc | 399,044 | $65.3M |
| VRDNViridian Therapeutics, Inc.\DE | 3,078,554 | $60.2M |
| PHVSPharvaris N.V. | 2,118,900 | $59.9M |
| ADPTAdaptive Biotechnologies Corp | 3,857,422 | $53.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 716,523 | $40.5M |
| TVTXTravere Therapeutics, Inc. | 1,022,272 | $30.4M |
| MANEVeradermics Incorporated | 477,833 | $30.2M |
| DMRADamora Therapeutics, Inc. | 1,058,000 | $27.4M |
| ROIVRoivant Sciences Ltd. | 963,282 | $26.7M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 2,818,348 | $25.2M |
| DFTXDefinium Therapeutics Inc. | 1,304,749 | $24.7M |
| ZBIOZenas BioPharma, Inc. | 1,246,053 | $24.4M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 273,757 | $23.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 641,486 | $21.7M |
| TERNTerns Pharmaceuticals, Inc. | 375,505 | $19.8M |
| CTMXCytomX Therapeutics, Inc. | 3,582,985 | $16.8M |
| KODKodiak Sciences Inc. | 436,329 | $16.6M |
| IMTXImmatics N.V. | 1,561,892 | $15.4M |
| SVRASavara Inc | 2,710,723 | $14.8M |
| TRDAEntrada Therapeutics, Inc. | 1,034,782 | $13.1M |
| XERSXeris Biopharma Holdings, Inc. | 2,171,354 | $12.6M |
| APLSApellis Pharmaceuticals, Inc. | 249,635 | $10.0M |
| OLMAOlema Pharmaceuticals, Inc. | 664,679 | $9.9M |
| PMNProMIS Neurosciences Inc. | 696,378 | $8.8M |
| VCELVericel Corp | 272,777 | $8.8M |
| LQDALiquidia Corp | 199,060 | $7.5M |
| SMMTSummit Therapeutics Inc. | 362,858 | $6.9M |
| ONCBeOne Medicines Ltd. | 20,828 | $6.2M |
| TNGXTango Therapeutics, Inc. | 289,180 | $6.0M |
| ORKAOruka Therapeutics, Inc. | 121,225 | $5.9M |
| ELVNEnliven Therapeutics, Inc. | 150,126 | $5.9M |
| ALMSALUMIS INC. | 239,231 | $5.3M |
| NRIXNurix Therapeutics, Inc. | 321,360 | $5.0M |
| PVLAPALVELLA THERAPEUTICS, INC. | 34,040 | $4.2M |
| EXELEXELIXIS, INC. | 82,092 | $3.5M |
| ZYMEZymeworks Inc. | 138,690 | $3.5M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 54,518 | $3.4M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 108,604 | $3.3M |
| HROWHARROW, INC. | 87,393 | $3.1M |
| UPBUpstream Bio, Inc. | 342,353 | $3.1M |
| ANNXAnnexon, Inc. | 521,379 | $2.9M |
| NUVBNuvation Bio Inc. | 672,144 | $2.9M |
| ANABANAPTYSBIO, INC | 46,881 | $2.6M |
| RDYDR REDDYS LABORATORIES LTD | 170,576 | $2.4M |
| ORICOric Pharmaceuticals, Inc. | 186,099 | $2.4M |
| KALVKalVista Pharmaceuticals, Inc. | 107,262 | $2.2M |
| CGEMCullinan Therapeutics, Inc. | 149,626 | $2.1M |
| TGTXTG THERAPEUTICS, INC. | 59,965 | $2.0M |
| ABUSArbutus Biopharma Corp | 440,924 | $2.0M |
| PGENPRECIGEN, INC. | 508,434 | $2.0M |
| ESPREsperion Therapeutics, Inc. | 695,848 | $1.9M |
| CMPXCompass Therapeutics, Inc. | 360,125 | $1.9M |
| SIONSionna Therapeutics, Inc. | 46,079 | $1.8M |
| JBIOJade Biosciences, Inc. | 129,166 | $1.8M |
| MAZEMaze Therapeutics, Inc. | 60,587 | $1.8M |
| PLSEPulse Biosciences Inc Common Stock (DE) | 81,252 | $1.8M |
| LGNDLigand Pharmaceuticals Incorporated | 7,906 | $1.6M |
| SLSSELLAS Life Sciences Group, Inc. | 344,778 | $1.5M |
| ZVRAZEVRA THERAPEUTICS, INC. | 156,417 | $1.5M |
| LBRXLB PHARMACEUTICALS INC | 52,640 | $1.3M |
| ARTVArtiva Biotherapeutics, Inc. | 194,108 | $1.3M |
| AQSTAquestive Therapeutics, Inc. | 290,060 | $1.2M |
| BIOABioAge Labs, Inc. | 67,681 | $1.2M |
| SLDBSolid Biosciences Inc. | 161,278 | $1.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 21,861 | $1.1M |
| ACADACADIA PHARMACEUTICALS INC | 49,981 | $1.1M |
| ABSIAbsci Corporation | 366,808 | $1.1M |
| ARQTArcutis Biotherapeutics, Inc. | 44,373 | $1.0M |
| IBRXImmunityBio, Inc. | 133,855 | $1.0M |
| DNLIDenali Therapeutics Inc. | 53,363 | $1.0M |
| FDMT4D Molecular Therapeutics, Inc. | 108,872 | $1.0M |
| OGNOrganon & Co. | 167,327 | $1.0M |
| MPLTMapLight Therapeutics, Inc. | 46,208 | $939K |
| BEAMBeam Therapeutics Inc. | 38,824 | $925K |
| TECXTectonic Therapeutic, Inc. | 29,240 | $904K |
| ADMAADMA BIOLOGICS, INC. | 95,213 | $858K |
| ALTAltimmune, Inc. | 248,158 | $764K |
| FBRXForte Biosciences, Inc. | 29,491 | $764K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 26,496 | $735K |
| IMVTImmunovant, Inc. | 28,525 | $709K |
| CATXPerspective Therapeutics, Inc. | 168,223 | $701K |
| ZURAZura Bio Ltd | 116,686 | $694K |
| AVXLANAVEX LIFE SCIENCES CORP. | 219,090 | $673K |
| OCULOCULAR THERAPEUTIX, INC | 75,358 | $638K |
| LRMRLarimar Therapeutics, Inc. | 136,530 | $614K |
| INVAInnoviva, Inc. | 25,454 | $593K |
| ANIPANI PHARMACEUTICALS INC | 7,543 | $580K |
| ARDXARDELYX, INC. | 95,184 | $570K |
| NTLAIntellia Therapeutics, Inc. | 42,359 | $543K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 151,419 | $465K |
| ALDXAldeyra Therapeutics, Inc. | 148,962 | $252K |