| GILDGILEAD SCIENCES, INC. | 3,052,813 | $425.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 349,912 | $270.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 148,488 | $49.1M |
| PTGXProtagonist Therapeutics, Inc | 454,383 | $47.9M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 656,129 | $41.1M |
| BBIOBridgeBio Pharma, Inc. | 538,980 | $40.0M |
| INSMINSMED Inc | 243,706 | $39.9M |
| SRRKScholar Rock Holding Corp | 725,409 | $35.7M |
| AXSMAxsome Therapeutics, Inc. | 183,967 | $31.1M |
| COGTCogent Biosciences, Inc. | 664,146 | $25.6M |
| PTCTPTC THERAPEUTICS, INC. | 342,637 | $23.3M |
| MRNAModerna, Inc. | 439,076 | $22.3M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 233,810 | $20.3M |
| NUVLNuvalent, Inc. | 178,438 | $18.3M |
| CYTKCYTOKINETICS INC | 259,459 | $17.1M |
| TGTXTG THERAPEUTICS, INC. | 419,609 | $13.9M |
| ACADACADIA PHARMACEUTICALS INC | 613,784 | $13.7M |
| JAZZJazz Pharmaceuticals plc | 64,042 | $12.1M |
| INCYIncyte Corp. | 106,738 | $10.0M |
| TERNTerns Pharmaceuticals, Inc. | 165,562 | $8.7M |
| ROIVRoivant Sciences Ltd. | 314,440 | $8.7M |
| EXELEXELIXIS, INC. | 202,573 | $8.7M |
| TVTXTravere Therapeutics, Inc. | 196,541 | $5.8M |
| IONSIONIS PHARMACEUTICALS INC | 69,136 | $5.2M |
| VRDNViridian Therapeutics, Inc.\DE | 262,017 | $5.1M |
| RVMDREVOLUTION MEDICINES, INC. | 47,766 | $4.6M |
| TEVATeva Pharmaceutical Industries Limited | 145,045 | $4.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 74,360 | $4.2M |
| SVRASavara Inc | 756,774 | $4.1M |
| ARGXARGENX SE | 5,545 | $4.0M |
| TNGXTango Therapeutics, Inc. | 175,469 | $3.7M |
| XERSXeris Biopharma Holdings, Inc. | 625,310 | $3.6M |
| PCVXVaxcyte, Inc. | 61,563 | $3.6M |
| ORKAOruka Therapeutics, Inc. | 66,600 | $3.3M |
| SYRESpyre Therapeutics, Inc. | 53,970 | $2.7M |
| SMMTSummit Therapeutics Inc. | 130,237 | $2.5M |
| APGEApogee Therapeutics, Inc. | 28,378 | $2.4M |
| GPCRStructure Therapeutics Inc. | 44,410 | $2.1M |
| ABVXAbivax SA | 18,500 | $2.1M |
| CMPXCompass Therapeutics, Inc. | 375,320 | $2.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 34,385 | $1.9M |
| OLMAOlema Pharmaceuticals, Inc. | 121,494 | $1.8M |
| APLSApellis Pharmaceuticals, Inc. | 43,669 | $1.8M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 31,748 | $1.6M |
| ALMSALUMIS INC. | 73,909 | $1.6M |
| IBRXImmunityBio, Inc. | 191,552 | $1.5M |
| IMVTImmunovant, Inc. | 54,286 | $1.3M |
| OPKOPKO HEALTH, INC. | 1,160,927 | $1.3M |
| CNTACentessa Pharmaceuticals plc | 29,670 | $1.2M |
| BEAMBeam Therapeutics Inc. | 41,493 | $989K |
| VKTXViking Therapeutics, Inc. | 29,071 | $946K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 27,050 | $866K |
| ADMAADMA BIOLOGICS, INC. | 89,795 | $809K |
| ANABANAPTYSBIO, INC | 14,346 | $796K |
| FOLDAMICUS THERAPEUTICS, INC. | 49,413 | $715K |
| OCULOCULAR THERAPEUTIX, INC | 83,664 | $709K |
| ADPTAdaptive Biotechnologies Corp | 48,832 | $678K |
| LGNDLigand Pharmaceuticals Incorporated | 3,356 | $670K |
| VCELVericel Corp | 20,318 | $654K |
| PVLAPALVELLA THERAPEUTICS, INC. | 5,152 | $642K |
| ONCBeOne Medicines Ltd. | 2,020 | $600K |
| ARDXARDELYX, INC. | 97,865 | $586K |
| NTLAIntellia Therapeutics, Inc. | 45,111 | $578K |
| NRIXNurix Therapeutics, Inc. | 36,787 | $570K |
| ELVNEnliven Therapeutics, Inc. | 14,491 | $568K |
| SANASana Biotechnology, Inc. | 181,594 | $523K |
| ANIPANI PHARMACEUTICALS INC | 6,783 | $522K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 6,077 | $510K |
| CATXPerspective Therapeutics, Inc. | 115,489 | $482K |
| SPRYARS Pharmaceuticals, Inc. | 58,373 | $469K |
| DNLIDenali Therapeutics Inc. | 23,672 | $455K |
| ORGOOrganogenesis Holdings Inc. | 190,493 | $451K |
| ARQTArcutis Biotherapeutics, Inc. | 18,890 | $445K |
| LQDALiquidia Corp | 11,766 | $444K |
| FDMT4D Molecular Therapeutics, Inc. | 45,359 | $422K |
| KODKodiak Sciences Inc. | 10,661 | $406K |
| CLDXCelldex Therapeutics, Inc. | 11,719 | $372K |
| BCAXBicara Therapeutics Inc. | 18,008 | $358K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 9,996 | $338K |
| DFTXDefinium Therapeutics Inc. | 16,384 | $310K |
| RCUSArcus Biosciences, Inc. | 14,006 | $303K |
| DAWNDay One Biopharmaceuticals, Inc. | 13,242 | $284K |
| IRONDisc Medicine, Inc. | 4,420 | $283K |
| SLNOSOLENO THERAPEUTICS INC | 8,351 | $280K |
| STOKStoke Therapeutics, Inc. | 8,205 | $267K |
| INVAInnoviva, Inc. | 11,059 | $258K |
| QUREuniQure N.V. | 15,520 | $254K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 76,783 | $236K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 7,420 | $226K |
| ZYMEZymeworks Inc. | 8,993 | $225K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 57,441 | $202K |
| NUVBNuvation Bio Inc. | 41,989 | $180K |
| BHVNBiohaven Ltd. | 19,967 | $169K |
| GERNGERON CORP | 101,203 | $151K |
| ORICOric Pharmaceuticals, Inc. | 11,222 | $142K |
| ABUSArbutus Biopharma Corp | 28,676 | $129K |
| SLSSELLAS Life Sciences Group, Inc. | 29,262 | $124K |
| ANNXAnnexon, Inc. | 22,227 | $123K |
| PGENPRECIGEN, INC. | 31,153 | $121K |
| KURAKura Oncology, Inc. | 14,360 | $117K |
| ARVNARVINAS, INC. | 10,743 | $114K |
| OGNOrganon & Co. | 19,006 | $114K |
| ESPREsperion Therapeutics, Inc. | 39,818 | $109K |
| SLDBSolid Biosciences Inc. | 10,684 | $77K |
| AQSTAquestive Therapeutics, Inc. | 17,472 | $73K |
| ABSIAbsci Corporation | 22,678 | $68K |
| ALTAltimmune, Inc. | 21,011 | $65K |
| RCKTRocket Pharmaceuticals Inc. | 14,650 | $52K |
| AVXLANAVEX LIFE SCIENCES CORP. | 14,980 | $46K |
| RZLTRezolute, Inc. | 12,776 | $39K |
| ALECAlector, Inc. | 15,478 | $33K |
| CHRSCoherus Oncology, Inc. | 16,971 | $29K |
| FATEFATE THERAPEUTICS INC | 22,502 | $27K |
| PLXProtalix BioTherapeutics, Inc. | 11,494 | $25K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 25,601 | $20K |
| CRDFCardiff Oncology, Inc. | 11,752 | $19K |
| HUMAHumacyte Inc. | 26,772 | $16K |