| GILDGILEAD SCIENCES, INC. | 1,333,114 | $182.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 109,720 | $84.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 139,708 | $46.1M |
| JAZZJazz Pharmaceuticals plc | 134,724 | $25.5M |
| INCYIncyte Corp. | 235,852 | $22.2M |
| EXELEXELIXIS, INC. | 489,382 | $21.0M |
| INSMINSMED Inc | 120,348 | $19.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 303,169 | $16.7M |
| IONSIONIS PHARMACEUTICALS INC | 219,652 | $16.5M |
| BBIOBridgeBio Pharma, Inc. | 199,645 | $14.8M |
| AXSMAxsome Therapeutics, Inc. | 70,725 | $12.0M |
| PTGXProtagonist Therapeutics, Inc | 105,514 | $11.1M |
| APGEApogee Therapeutics, Inc. | 128,015 | $10.8M |
| PTCTPTC THERAPEUTICS, INC. | 129,682 | $8.8M |
| SRRKScholar Rock Holding Corp | 177,377 | $8.7M |
| SYRESpyre Therapeutics, Inc. | 170,381 | $8.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 120,238 | $7.5M |
| TVTXTravere Therapeutics, Inc. | 246,648 | $7.3M |
| MRNAModerna, Inc. | 135,932 | $7.0M |
| RVMDREVOLUTION MEDICINES, INC. | 56,602 | $5.5M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 62,936 | $5.5M |
| GPCRStructure Therapeutics Inc. | 109,638 | $5.3M |
| LGNDLigand Pharmaceuticals Incorporated | 25,240 | $5.0M |
| KNSAKiniksa Pharmaceuticals International, plc | 104,654 | $5.0M |
| NUVLNuvalent, Inc. | 46,382 | $4.8M |
| ARQTArcutis Biotherapeutics, Inc. | 190,014 | $4.5M |
| PCVXVaxcyte, Inc. | 66,416 | $3.9M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 72,430 | $3.7M |
| CYTKCYTOKINETICS INC | 55,390 | $3.7M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 41,087 | $3.4M |
| OGNOrganon & Co. | 523,472 | $3.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 50,643 | $2.9M |
| INVAInnoviva, Inc. | 115,021 | $2.7M |
| FOLDAMICUS THERAPEUTICS, INC. | 176,804 | $2.6M |
| IRONDisc Medicine, Inc. | 38,006 | $2.4M |
| NTLAIntellia Therapeutics, Inc. | 186,781 | $2.4M |
| CLDXCelldex Therapeutics, Inc. | 70,053 | $2.2M |
| ARDXARDELYX, INC. | 357,180 | $2.1M |
| VCELVericel Corp | 66,422 | $2.1M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 60,679 | $2.1M |
| ROIVRoivant Sciences Ltd. | 71,798 | $2.0M |
| DNLIDenali Therapeutics Inc. | 99,503 | $1.9M |
| COGTCogent Biosciences, Inc. | 45,233 | $1.7M |
| BEAMBeam Therapeutics Inc. | 69,013 | $1.6M |
| ADPTAdaptive Biotechnologies Corp | 104,698 | $1.5M |
| OCULOCULAR THERAPEUTIX, INC | 165,984 | $1.4M |
| VRDNViridian Therapeutics, Inc.\DE | 48,822 | $955K |
| TGTXTG THERAPEUTICS, INC. | 25,970 | $863K |
| DNAGinkgo Bioworks Holdings Inc. | 140,000 | $858K |
| IMVTImmunovant, Inc. | 33,173 | $824K |
| ZYMEZymeworks Inc. | 30,432 | $762K |
| ADMAADMA BIOLOGICS, INC. | 83,356 | $751K |
| ACADACADIA PHARMACEUTICALS INC | 33,079 | $736K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 227,663 | $699K |
| RCUSArcus Biosciences, Inc. | 31,663 | $684K |
| SLNOSOLENO THERAPEUTICS INC | 17,048 | $571K |
| STOKStoke Therapeutics, Inc. | 16,206 | $528K |
| SVRASavara Inc | 90,000 | $491K |
| PVLAPALVELLA THERAPEUTICS, INC. | 3,544 | $442K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 458,766 | $367K |
| APLSApellis Pharmaceuticals, Inc. | 6,977 | $281K |
| TERNTerns Pharmaceuticals, Inc. | 5,130 | $270K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 39,308 | $251K |
| VKTXViking Therapeutics, Inc. | 7,597 | $247K |
| ANIPANI PHARMACEUTICALS INC | 3,081 | $237K |
| IBRXImmunityBio, Inc. | 21,904 | $168K |
| FLGTFulgent Genetics Inc. | 10,155 | $161K |
| RLAYRelay Therapeutics, Inc. | 13,869 | $138K |
| CTMXCytomX Therapeutics, Inc. | 26,660 | $125K |
| BHVNBiohaven Ltd. | 10,830 | $92K |
| XERSXeris Biopharma Holdings, Inc. | 14,192 | $82K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 16,029 | $56K |
| ZNTLZentalis Pharmaceuticals, Inc. | 22,447 | $53K |
| GERNGERON CORP | 32,727 | $49K |
| ATAIAtai Beckley N.V. | 10,000 | $35K |
| PLRXPLIANT THERAPEUTICS, INC. | 18,065 | $23K |
| OPKOPKO HEALTH, INC. | 14,823 | $17K |