| GILDGILEAD SCIENCES, INC. | 3,641,000 | $507.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 303,140 | $234.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 387,720 | $128.3M |
| TEVATeva Pharmaceutical Industries Limited | 4,227,900 | $127.3M |
| INSMINSMED Inc | 625,912 | $102.3M |
| INCYIncyte Corp. | 489,774 | $46.1M |
| RVMDREVOLUTION MEDICINES, INC. | 425,431 | $41.4M |
| MRNAModerna, Inc. | 696,100 | $35.4M |
| IONSIONIS PHARMACEUTICALS INC | 304,500 | $22.9M |
| EXELEXELIXIS, INC. | 504,300 | $21.6M |
| BBIOBridgeBio Pharma, Inc. | 286,000 | $21.2M |
| ROIVRoivant Sciences Ltd. | 743,446 | $20.6M |
| JAZZJazz Pharmaceuticals plc | 108,200 | $20.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 361,100 | $20.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 242,000 | $15.2M |
| CYTKCYTOKINETICS INC | 229,800 | $15.1M |
| PCVXVaxcyte, Inc. | 233,100 | $13.5M |
| AXSMAxsome Therapeutics, Inc. | 69,100 | $11.7M |
| PTGXProtagonist Therapeutics, Inc | 98,900 | $10.4M |
| TGTXTG THERAPEUTICS, INC. | 298,400 | $9.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 112,200 | $9.8M |
| PTCTPTC THERAPEUTICS, INC. | 142,865 | $9.7M |
| NUVLNuvalent, Inc. | 78,900 | $8.1M |
| FOLDAMICUS THERAPEUTICS, INC. | 551,000 | $8.0M |
| LGNDLigand Pharmaceuticals Incorporated | 38,900 | $7.8M |
| VKTXViking Therapeutics, Inc. | 212,500 | $6.9M |
| COGTCogent Biosciences, Inc. | 165,400 | $6.4M |
| APGEApogee Therapeutics, Inc. | 75,600 | $6.4M |
| SRRKScholar Rock Holding Corp | 123,200 | $6.1M |
| APLSApellis Pharmaceuticals, Inc. | 149,500 | $6.0M |
| TERNTerns Pharmaceuticals, Inc. | 112,500 | $5.9M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 113,500 | $5.9M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 69,000 | $5.8M |
| DNLIDenali Therapeutics Inc. | 273,800 | $5.3M |
| IBRXImmunityBio, Inc. | 682,400 | $5.2M |
| ACADACADIA PHARMACEUTICALS INC | 234,404 | $5.2M |
| ARQTArcutis Biotherapeutics, Inc. | 218,200 | $5.1M |
| TVTXTravere Therapeutics, Inc. | 168,100 | $5.0M |
| SYRESpyre Therapeutics, Inc. | 96,500 | $4.9M |
| LQDALiquidia Corp | 120,400 | $4.5M |
| BEAMBeam Therapeutics Inc. | 180,600 | $4.3M |
| ADMAADMA BIOLOGICS, INC. | 470,600 | $4.2M |
| IMVTImmunovant, Inc. | 159,400 | $4.0M |
| CLDXCelldex Therapeutics, Inc. | 117,900 | $3.7M |
| RCUSArcus Biosciences, Inc. | 171,296 | $3.7M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 108,860 | $3.7M |
| NKTRNEKTAR THERAPEUTICS | 47,900 | $3.4M |
| KNSAKiniksa Pharmaceuticals International, plc | 71,500 | $3.4M |
| INVAInnoviva, Inc. | 140,500 | $3.3M |
| VCELVericel Corp | 99,500 | $3.2M |
| ADPTAdaptive Biotechnologies Corp | 225,200 | $3.1M |
| OGNOrganon & Co. | 512,575 | $3.1M |
| IRONDisc Medicine, Inc. | 48,000 | $3.1M |
| DAWNDay One Biopharmaceuticals, Inc. | 141,500 | $3.0M |
| SLNOSOLENO THERAPEUTICS INC | 90,300 | $3.0M |
| DFTXDefinium Therapeutics Inc. | 158,400 | $3.0M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 96,800 | $2.9M |
| ARDXARDELYX, INC. | 480,800 | $2.9M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 88,900 | $2.8M |
| ALMSALUMIS INC. | 127,800 | $2.8M |
| NTLAIntellia Therapeutics, Inc. | 217,800 | $2.8M |
| ANIPANI PHARMACEUTICALS INC | 35,500 | $2.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 877,000 | $2.7M |
| OCULOCULAR THERAPEUTIX, INC | 313,300 | $2.7M |
| STOKStoke Therapeutics, Inc. | 79,100 | $2.6M |
| ELVNEnliven Therapeutics, Inc. | 64,273 | $2.5M |
| VRDNViridian Therapeutics, Inc.\DE | 128,600 | $2.5M |
| PVLAPALVELLA THERAPEUTICS, INC. | 19,400 | $2.4M |
| RLAYRelay Therapeutics, Inc. | 238,000 | $2.4M |
| NRIXNurix Therapeutics, Inc. | 150,000 | $2.3M |
| HROWHARROW, INC. | 62,100 | $2.2M |
| KODKodiak Sciences Inc. | 57,400 | $2.2M |
| BHVNBiohaven Ltd. | 258,600 | $2.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 606,456 | $2.1M |
| ORKAOruka Therapeutics, Inc. | 43,000 | $2.1M |
| XERSXeris Biopharma Holdings, Inc. | 328,300 | $1.9M |
| NUVBNuvation Bio Inc. | 437,400 | $1.9M |
| ZYMEZymeworks Inc. | 74,200 | $1.9M |
| TNGXTango Therapeutics, Inc. | 87,800 | $1.8M |
| ANABANAPTYSBIO, INC | 27,600 | $1.5M |
| CTMXCytomX Therapeutics, Inc. | 319,600 | $1.5M |
| GERNGERON CORP | 947,500 | $1.4M |
| PGENPRECIGEN, INC. | 349,000 | $1.4M |
| ANNXAnnexon, Inc. | 236,000 | $1.3M |
| QUREuniQure N.V. | 79,000 | $1.3M |
| ABUSArbutus Biopharma Corp | 283,400 | $1.3M |
| PHVSPharvaris N.V. | 44,757 | $1.3M |
| KURAKura Oncology, Inc. | 145,600 | $1.2M |
| CMPXCompass Therapeutics, Inc. | 220,700 | $1.2M |
| ATAIAtai Beckley N.V. | 325,900 | $1.2M |
| MLTXMoonLake Immunotherapeutics | 61,500 | $1.1M |
| ARVNARVINAS, INC. | 108,000 | $1.1M |
| OLMAOlema Pharmaceuticals, Inc. | 74,600 | $1.1M |
| KALVKalVista Pharmaceuticals, Inc. | 54,900 | $1.1M |
| BCAXBicara Therapeutics Inc. | 55,000 | $1.1M |
| ORICOric Pharmaceuticals, Inc. | 86,200 | $1.1M |
| SANASana Biotechnology, Inc. | 342,600 | $987K |
| OPKOPKO HEALTH, INC. | 845,755 | $964K |
| SPRYARS Pharmaceuticals, Inc. | 107,200 | $861K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 39,100 | $844K |
| CGEMCullinan Therapeutics, Inc. | 58,300 | $828K |
| SVRASavara Inc | 136,800 | $747K |
| FLGTFulgent Genetics Inc. | 39,200 | $623K |
| ZBIOZenas BioPharma, Inc. | 31,600 | $618K |
| UPBUpstream Bio, Inc. | 48,100 | $433K |
| DNAGinkgo Bioworks Holdings Inc. | 65,063 | $399K |
| LENZLENZ Therapeutics, Inc. | 21,800 | $199K |