Siren, L.L.C.

Source: SEC Form 13F · as of Mar 2026

Siren, L.L.C. holds 37 biotech & pharma companies tracked by BioSniper, totaling $1.50B in value as of Mar 2026 (SEC Form 13F).

Companies held

37

Total value held

$1.50B

CompanySharesValue
ONCBeOne Medicines Ltd.465,000$138.1M
TNGXTango Therapeutics, Inc.5,657,105$118.3M
RVMDREVOLUTION MEDICINES, INC.1,110,980$108.0M
ARWRARROWHEAD PHARMACEUTICALS, INC.1,615,476$101.3M
XENEXenon Pharmaceuticals Inc.1,318,564$76.7M
CRNXCrinetics Pharmaceuticals, Inc.1,903,636$69.1M
COGTCogent Biosciences, Inc.1,709,279$65.8M
STOKStoke Therapeutics, Inc.1,995,347$65.0M
GPCRStructure Therapeutics Inc.1,328,698$64.0M
IRONDisc Medicine, Inc.988,401$63.2M
RYTMRHYTHM PHARMACEUTICALS, INC.725,511$63.1M
CNTACentessa Pharmaceuticals plc1,053,464$41.8M
SYRESpyre Therapeutics, Inc.818,598$41.3M
CYTKCYTOKINETICS INC613,952$40.5M
DYNDyne Therapeutics, Inc.2,229,125$40.4M
TSHATaysha Gene Therapies, Inc.8,829,913$39.5M
ORICOric Pharmaceuticals, Inc.2,998,192$38.0M
PVLAPALVELLA THERAPEUTICS, INC.257,485$32.1M
ELVNEnliven Therapeutics, Inc.746,226$29.3M
DNLIDenali Therapeutics Inc.1,396,513$26.8M
DMRADamora Therapeutics, Inc.900,000$23.3M
ANNXAnnexon, Inc.3,958,646$21.9M
TRVITrevi Therapeutics, Inc.1,786,867$21.3M
RAPPRapport Therapeutics, Inc.641,469$20.1M
WVEWave Life Sciences Ltd.2,450,000$17.8M
DFTXDefinium Therapeutics Inc.919,493$17.4M
AMLXAmylyx Pharmaceuticals, Inc.1,230,000$17.1M
CGEMCullinan Therapeutics, Inc.1,193,410$17.0M
QUREuniQure N.V.1,000,000$16.4M
CTMXCytomX Therapeutics, Inc.3,457,711$16.3M
SIONSionna Therapeutics, Inc.300,000$12.0M
GENBGenerate Biomedicines Inc.736,104$9.2M
MPLTMapLight Therapeutics, Inc.450,000$9.1M
ABSIAbsci Corporation1,800,000$5.4M
IVVDInvivyd, Inc.4,000,000$5.2M
AGMBAgomAb Therapeutics NV411,250$4.3M
KRROKorro Bio, Inc.347,718$3.9M

13F holdings reflect long positions in U.S.-listed securities as reported to the SEC. Values are point-in-time for the most recent reported quarter.