| GILDGILEAD SCIENCES, INC. | 3,447,111 | $480.4M |
| INSMINSMED Inc | 1,143,739 | $187.0M |
| AXSMAxsome Therapeutics, Inc. | 812,809 | $137.4M |
| LGNDLigand Pharmaceuticals Incorporated | 573,312 | $114.5M |
| BBIOBridgeBio Pharma, Inc. | 1,534,736 | $114.0M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 2,037,202 | $105.3M |
| TVTXTravere Therapeutics, Inc. | 3,270,513 | $97.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 258,905 | $85.7M |
| IONSIONIS PHARMACEUTICALS INC | 785,281 | $59.0M |
| FOLDAMICUS THERAPEUTICS, INC. | 3,559,972 | $51.5M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,494,435 | $50.6M |
| ARDXARDELYX, INC. | 8,169,369 | $48.9M |
| ARGXARGENX SE | 58,374 | $42.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 54,475 | $42.1M |
| ADPTAdaptive Biotechnologies Corp | 1,881,183 | $26.1M |
| EXELEXELIXIS, INC. | 532,744 | $22.8M |
| ANIPANI PHARMACEUTICALS INC | 287,563 | $22.1M |
| VCELVericel Corp | 630,879 | $20.3M |
| INCYIncyte Corp. | 185,081 | $17.4M |
| COGTCogent Biosciences, Inc. | 354,240 | $13.6M |
| VKTXViking Therapeutics, Inc. | 330,100 | $10.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 163,612 | $9.2M |
| ONCBeOne Medicines Ltd. | 30,664 | $9.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 155,589 | $8.6M |
| RCUSArcus Biosciences, Inc. | 379,100 | $8.2M |
| GPCRStructure Therapeutics Inc. | 134,015 | $6.5M |
| JAZZJazz Pharmaceuticals plc | 31,300 | $5.9M |
| ANABANAPTYSBIO, INC | 93,732 | $5.2M |
| QUREuniQure N.V. | 258,211 | $4.2M |
| CYTKCYTOKINETICS INC | 48,483 | $3.2M |
| IMVTImmunovant, Inc. | 122,100 | $3.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 42,754 | $2.7M |
| DAWNDay One Biopharmaceuticals, Inc. | 110,000 | $2.4M |
| SRRKScholar Rock Holding Corp | 47,820 | $2.4M |
| ARQTArcutis Biotherapeutics, Inc. | 98,847 | $2.3M |
| DNLIDenali Therapeutics Inc. | 114,524 | $2.2M |
| ACADACADIA PHARMACEUTICALS INC | 92,648 | $2.1M |
| OCULOCULAR THERAPEUTIX, INC | 234,547 | $2.0M |
| ARVNARVINAS, INC. | 180,000 | $1.9M |
| ADMAADMA BIOLOGICS, INC. | 198,933 | $1.8M |
| VRDNViridian Therapeutics, Inc.\DE | 85,390 | $1.7M |
| CHRSCoherus Oncology, Inc. | 899,999 | $1.5M |
| SIGASIGA TECHNOLOGIES INC | 244,853 | $1.3M |
| RGNXREGENXBIO Inc. | 149,000 | $1.2M |
| PCVXVaxcyte, Inc. | 20,000 | $1.2M |
| RDYDR REDDYS LABORATORIES LTD | 80,968 | $1.1M |
| PRQRProQR Therapeutics N.V. | 620,000 | $1.0M |
| MRNAModerna, Inc. | 19,284 | $980K |
| OGNOrganon & Co. | 136,800 | $819K |
| OLMAOlema Pharmaceuticals, Inc. | 50,000 | $746K |
| CLLSCellectis S.A. | 226,875 | $719K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 61,255 | $391K |
| ALTAltimmune, Inc. | 100,000 | $308K |
| NTLAIntellia Therapeutics, Inc. | 20,000 | $256K |
| RCKTRocket Pharmaceuticals Inc. | 58,000 | $208K |
| SGMOQSANGAMO THERAPEUTICS, INC | 400,000 | $99K |
| LITSLite Strategy, Inc. | 29,999 | $35K |