| APGEApogee Therapeutics, Inc. | 831,428 | $70.0M |
| GILDGILEAD SCIENCES, INC. | 296,654 | $41.3M |
| ORKAOruka Therapeutics, Inc. | 802,470 | $39.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 20,053 | $15.5M |
| CAPRCAPRICOR THERAPEUTICS, INC. | 402,999 | $12.3M |
| INCYIncyte Corp. | 93,266 | $8.8M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 155,860 | $8.6M |
| ORMPORAMED PHARMACEUTICALS INC. | 1,910,540 | $6.5M |
| EXELEXELIXIS, INC. | 136,747 | $5.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 90,472 | $5.1M |
| SNYSanofi | 86,017 | $4.1M |
| SYRESpyre Therapeutics, Inc. | 71,091 | $3.6M |
| PTCTPTC THERAPEUTICS, INC. | 50,357 | $3.4M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 8,579 | $2.8M |
| TEVATeva Pharmaceutical Industries Limited | 70,408 | $2.1M |
| JAZZJazz Pharmaceuticals plc | 11,117 | $2.1M |
| MRNAModerna, Inc. | 40,906 | $2.1M |
| ROIVRoivant Sciences Ltd. | 42,675 | $1.2M |
| INSMINSMED Inc | 5,732 | $937K |
| INVAInnoviva, Inc. | 36,317 | $846K |
| GMABGenmab A/S | 26,061 | $699K |
| IONSIONIS PHARMACEUTICALS INC | 6,296 | $473K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 8,678 | $449K |
| KNSAKiniksa Pharmaceuticals International, plc | 8,960 | $431K |
| APLSApellis Pharmaceuticals, Inc. | 10,663 | $429K |
| ARGXARGENX SE | 573 | $418K |
| BHVNBiohaven Ltd. | 49,225 | $416K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 6,316 | $396K |
| AXSMAxsome Therapeutics, Inc. | 2,259 | $382K |
| ARDXARDELYX, INC. | 60,232 | $361K |
| SRRKScholar Rock Holding Corp | 7,195 | $354K |
| DAWNDay One Biopharmaceuticals, Inc. | 16,411 | $352K |
| VKTXViking Therapeutics, Inc. | 10,059 | $327K |
| OGNOrganon & Co. | 51,981 | $311K |
| RCKTRocket Pharmaceuticals Inc. | 82,548 | $296K |
| IMTXImmatics N.V. | 29,987 | $295K |
| KURAKura Oncology, Inc. | 36,032 | $293K |
| ALMSALUMIS INC. | 12,765 | $281K |
| FOLDAMICUS THERAPEUTICS, INC. | 19,178 | $277K |
| NTLAIntellia Therapeutics, Inc. | 20,029 | $257K |
| RDYDR REDDYS LABORATORIES LTD | 18,198 | $252K |
| TGTXTG THERAPEUTICS, INC. | 7,496 | $249K |
| VCELVericel Corp | 7,255 | $233K |
| TVTXTravere Therapeutics, Inc. | 7,218 | $214K |
| CGEMCullinan Therapeutics, Inc. | 14,109 | $200K |
| RGNXREGENXBIO Inc. | 23,840 | $200K |
| OCULOCULAR THERAPEUTIX, INC | 19,621 | $166K |
| NUVBNuvation Bio Inc. | 37,069 | $159K |
| ARVNARVINAS, INC. | 12,246 | $130K |
| KROSKeros Therapeutics, Inc. | 11,742 | $130K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 13,094 | $127K |
| GERNGERON CORP | 82,314 | $123K |
| ADMAADMA BIOLOGICS, INC. | 11,639 | $105K |
| ANNXAnnexon, Inc. | 18,714 | $104K |
| SIGASIGA TECHNOLOGIES INC | 18,879 | $101K |
| XERSXeris Biopharma Holdings, Inc. | 16,988 | $99K |
| IBRXImmunityBio, Inc. | 12,741 | $94K |
| CATXPerspective Therapeutics, Inc. | 22,269 | $93K |
| ABUSArbutus Biopharma Corp | 19,345 | $87K |
| LRMRLarimar Therapeutics, Inc. | 17,084 | $77K |
| RZLTRezolute, Inc. | 24,183 | $74K |
| ATAIAtai Beckley N.V. | 19,683 | $70K |
| ABSIAbsci Corporation | 22,482 | $67K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 21,349 | $66K |
| ALDXAldeyra Therapeutics, Inc. | 37,742 | $64K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 17,997 | $63K |
| OPKOPKO HEALTH, INC. | 52,832 | $60K |
| FATEFATE THERAPEUTICS INC | 49,804 | $60K |
| RNTXRein Therapeutics, Inc. | 35,461 | $46K |
| AVXLANAVEX LIFE SCIENCES CORP. | 15,005 | $46K |
| HUMAHumacyte Inc. | 60,593 | $37K |
| SANASana Biotechnology, Inc. | 12,644 | $36K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 41,038 | $33K |
| GALTGALECTIN THERAPEUTICS INC | 10,113 | $28K |
| HURATuHURA Biosciences, Inc./NV | 14,809 | $27K |
| CHRSCoherus Oncology, Inc. | 14,917 | $25K |
| CGTXCOGNITION THERAPEUTICS INC | 15,951 | $12K |