| REGNREGENERON PHARMACEUTICALS, INC. | 123,954 | $95.7M |
| GILDGILEAD SCIENCES, INC. | 621,970 | $86.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,231,009 | $67.9M |
| TERNTerns Pharmaceuticals, Inc. | 557,361 | $29.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 268,901 | $15.2M |
| EXELEXELIXIS, INC. | 307,928 | $13.2M |
| INCYIncyte Corp. | 121,091 | $11.4M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 29,948 | $9.9M |
| JAZZJazz Pharmaceuticals plc | 40,016 | $7.6M |
| ROIVRoivant Sciences Ltd. | 202,316 | $5.6M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 563,082 | $5.5M |
| SNYSanofi | 98,755 | $4.8M |
| TEVATeva Pharmaceutical Industries Limited | 131,941 | $4.0M |
| INSMINSMED Inc | 22,072 | $3.6M |
| RDYDR REDDYS LABORATORIES LTD | 221,274 | $3.1M |
| AXSMAxsome Therapeutics, Inc. | 16,814 | $2.8M |
| ARGXARGENX SE | 3,618 | $2.6M |
| GPCRStructure Therapeutics Inc. | 34,480 | $1.7M |
| ALMSALUMIS INC. | 73,123 | $1.6M |
| GMABGenmab A/S | 56,309 | $1.5M |
| ABVXAbivax SA | 11,006 | $1.2M |
| DAWNDay One Biopharmaceuticals, Inc. | 52,342 | $1.1M |
| TGTXTG THERAPEUTICS, INC. | 33,102 | $1.1M |
| BCAXBicara Therapeutics Inc. | 55,037 | $1.1M |
| DRTSAlpha Tau Medical Ltd. | 146,396 | $1.0M |
| GRFSGrifols S.A. | 125,151 | $1.0M |
| BMEABiomea Fusion, Inc. | 654,578 | $1.0M |
| CGEMCullinan Therapeutics, Inc. | 62,718 | $891K |
| LQDALiquidia Corp | 22,791 | $860K |
| MLTXMoonLake Immunotherapeutics | 44,950 | $838K |
| BHVNBiohaven Ltd. | 95,376 | $807K |
| KNSAKiniksa Pharmaceuticals International, plc | 16,318 | $786K |
| KURAKura Oncology, Inc. | 92,811 | $754K |
| PCVXVaxcyte, Inc. | 12,980 | $754K |
| SLSSELLAS Life Sciences Group, Inc. | 173,570 | $734K |
| PTCTPTC THERAPEUTICS, INC. | 10,571 | $720K |
| HRMYHarmony Biosciences Holdings, Inc. | 25,115 | $703K |
| RCKTRocket Pharmaceuticals Inc. | 190,111 | $680K |
| NTLAIntellia Therapeutics, Inc. | 51,903 | $665K |
| DFTXDefinium Therapeutics Inc. | 34,851 | $659K |
| SRRKScholar Rock Holding Corp | 12,121 | $595K |
| ARQTArcutis Biotherapeutics, Inc. | 23,774 | $560K |
| PVLAPALVELLA THERAPEUTICS, INC. | 4,420 | $551K |
| ESPREsperion Therapeutics, Inc. | 173,793 | $476K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 15,417 | $469K |
| RLYBRallybio Corp | 50,566 | $454K |
| ARDXARDELYX, INC. | 70,498 | $422K |
| TLXTelix Pharmaceuticals Limited | 43,446 | $415K |
| NRIXNurix Therapeutics, Inc. | 26,238 | $407K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 114,292 | $401K |
| DNAGinkgo Bioworks Holdings Inc. | 60,299 | $370K |
| INVAInnoviva, Inc. | 15,408 | $359K |
| DNLIDenali Therapeutics Inc. | 18,131 | $348K |
| NGNENeurogene Inc. | 16,687 | $336K |
| CCCCC4 Therapeutics, Inc. | 127,517 | $334K |
| IBRXImmunityBio, Inc. | 43,374 | $333K |
| TVTXTravere Therapeutics, Inc. | 10,847 | $322K |
| RGNXREGENXBIO Inc. | 37,999 | $318K |
| VCELVericel Corp | 9,705 | $312K |
| ONCBeOne Medicines Ltd. | 1,001 | $297K |
| ANNXAnnexon, Inc. | 53,242 | $295K |
| PTGXProtagonist Therapeutics, Inc | 2,775 | $292K |
| KRROKorro Bio, Inc. | 25,819 | $292K |
| ADMAADMA BIOLOGICS, INC. | 29,554 | $266K |
| ACADACADIA PHARMACEUTICALS INC | 11,518 | $257K |
| UPBUpstream Bio, Inc. | 27,314 | $246K |
| NUVBNuvation Bio Inc. | 55,401 | $238K |
| ARVNARVINAS, INC. | 20,046 | $212K |
| SGMTSagimet Biosciences Inc. | 38,800 | $203K |
| HCMHUTCHMED (China) Limited | 10,925 | $163K |
| AVXLANAVEX LIFE SCIENCES CORP. | 52,921 | $162K |
| ALDXAldeyra Therapeutics, Inc. | 91,870 | $155K |
| KROSKeros Therapeutics, Inc. | 13,826 | $153K |
| ZURAZura Bio Ltd | 24,734 | $147K |
| RZLTRezolute, Inc. | 47,752 | $146K |
| LRMRLarimar Therapeutics, Inc. | 31,645 | $142K |
| DSGNDesign Therapeutics, Inc. | 13,066 | $139K |
| XERSXeris Biopharma Holdings, Inc. | 23,081 | $134K |
| IMTXImmatics N.V. | 13,453 | $132K |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 12,806 | $120K |
| FATEFATE THERAPEUTICS INC | 98,295 | $118K |
| ABSIAbsci Corporation | 38,542 | $116K |
| SIGASIGA TECHNOLOGIES INC | 21,023 | $112K |
| OCULOCULAR THERAPEUTIX, INC | 12,782 | $108K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 14,649 | $94K |
| CTMXCytomX Therapeutics, Inc. | 19,750 | $93K |
| SPRYARS Pharmaceuticals, Inc. | 11,236 | $90K |
| TLPHTALPHERA, INC. | 100,000 | $75K |
| HUMAHumacyte Inc. | 106,278 | $64K |
| ORGOOrganogenesis Holdings Inc. | 24,986 | $59K |
| GALTGALECTIN THERAPEUTICS INC | 19,812 | $55K |
| OCGNOcugen, Inc. | 29,716 | $54K |
| CATXPerspective Therapeutics, Inc. | 11,815 | $49K |
| QNTMQuantum Biopharma Ltd. | 10,059 | $49K |
| HURATuHURA Biosciences, Inc./NV | 25,697 | $46K |
| CHRSCoherus Oncology, Inc. | 26,739 | $45K |
| OPKOPKO HEALTH, INC. | 39,346 | $45K |
| ALECAlector, Inc. | 18,799 | $40K |
| MISTMilestone Pharmaceuticals Inc. | 30,830 | $37K |
| PRQRProQR Therapeutics N.V. | 20,169 | $33K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 35,353 | $28K |
| VERUVERU INC. | 11,381 | $25K |
| CRDFCardiff Oncology, Inc. | 14,451 | $23K |
| LCTXLineage Cell Therapeutics, Inc. | 12,514 | $20K |
| MIRAMIRA PHARMACEUTICALS, INC. | 16,500 | $18K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 11,072 | $17K |
| TLSATiziana Life Sciences Ltd | 10,000 | $12K |
| HYFTMindWalk Holdings Corp. | 10,000 | $11K |
| BCABBioAtla, Inc. | 16,000 | $3K |
| QNCXQuince Therapeutics, Inc. | 12,673 | $1K |