| REGNREGENERON PHARMACEUTICALS, INC. | 315,212 | $243.5M |
| GILDGILEAD SCIENCES, INC. | 678,066 | $94.5M |
| INCYIncyte Corp. | 930,171 | $87.5M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 232,369 | $76.9M |
| ONCBeOne Medicines Ltd. | 241,922 | $71.8M |
| APLSApellis Pharmaceuticals, Inc. | 915,689 | $36.8M |
| RVMDREVOLUTION MEDICINES, INC. | 275,270 | $26.8M |
| JAZZJazz Pharmaceuticals plc | 135,212 | $25.6M |
| AXSMAxsome Therapeutics, Inc. | 142,271 | $24.0M |
| ROIVRoivant Sciences Ltd. | 852,204 | $23.6M |
| EXELEXELIXIS, INC. | 511,004 | $21.9M |
| INSMINSMED Inc | 126,840 | $20.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 309,659 | $17.5M |
| INVAInnoviva, Inc. | 744,791 | $17.4M |
| ANIPANI PHARMACEUTICALS INC | 208,694 | $16.0M |
| TERNTerns Pharmaceuticals, Inc. | 284,931 | $15.0M |
| HRMYHarmony Biosciences Holdings, Inc. | 461,898 | $12.9M |
| TGTXTG THERAPEUTICS, INC. | 354,697 | $11.8M |
| FOLDAMICUS THERAPEUTICS, INC. | 806,484 | $11.7M |
| VKTXViking Therapeutics, Inc. | 239,263 | $7.8M |
| COGTCogent Biosciences, Inc. | 194,801 | $7.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 127,186 | $6.1M |
| BEAMBeam Therapeutics Inc. | 231,994 | $5.5M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 144,297 | $4.9M |
| ZYMEZymeworks Inc. | 189,890 | $4.8M |
| DAWNDay One Biopharmaceuticals, Inc. | 200,000 | $4.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 74,992 | $3.9M |
| KURAKura Oncology, Inc. | 475,027 | $3.9M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 381,574 | $3.7M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 1,199,563 | $3.7M |
| APGEApogee Therapeutics, Inc. | 41,815 | $3.5M |
| ADPTAdaptive Biotechnologies Corp | 245,944 | $3.4M |
| SRRKScholar Rock Holding Corp | 62,118 | $3.1M |
| ACADACADIA PHARMACEUTICALS INC | 129,384 | $2.9M |
| NUVBNuvation Bio Inc. | 632,238 | $2.7M |
| DNLIDenali Therapeutics Inc. | 139,045 | $2.7M |
| KROSKeros Therapeutics, Inc. | 238,618 | $2.6M |
| NUVLNuvalent, Inc. | 24,258 | $2.5M |
| VCELVericel Corp | 69,643 | $2.2M |
| BBIOBridgeBio Pharma, Inc. | 28,207 | $2.1M |
| ATAIAtai Beckley N.V. | 543,515 | $1.9M |
| IONSIONIS PHARMACEUTICALS INC | 24,013 | $1.8M |
| RCUSArcus Biosciences, Inc. | 80,866 | $1.7M |
| XERSXeris Biopharma Holdings, Inc. | 276,422 | $1.6M |
| RGNXREGENXBIO Inc. | 187,625 | $1.6M |
| ARQTArcutis Biotherapeutics, Inc. | 64,219 | $1.5M |
| OCULOCULAR THERAPEUTIX, INC | 177,468 | $1.5M |
| NKTRNEKTAR THERAPEUTICS | 19,446 | $1.4M |
| BDTXBlack Diamond Therapeutics, Inc. | 559,700 | $1.2M |
| LGNDLigand Pharmaceuticals Incorporated | 5,644 | $1.1M |
| PCVXVaxcyte, Inc. | 19,257 | $1.1M |
| RDYDR REDDYS LABORATORIES LTD | 73,752 | $1.0M |
| ARVNARVINAS, INC. | 90,969 | $964K |
| AGENAGENUS INC | 278,980 | $932K |
| ESPREsperion Therapeutics, Inc. | 339,775 | $931K |
| KALVKalVista Pharmaceuticals, Inc. | 42,576 | $857K |
| MRNAModerna, Inc. | 14,277 | $725K |
| AVTXAvalo Therapeutics, Inc. | 46,553 | $695K |
| SLNOSOLENO THERAPEUTICS INC | 20,678 | $692K |
| NTLAIntellia Therapeutics, Inc. | 53,795 | $690K |
| CYTKCYTOKINETICS INC | 10,463 | $690K |
| CCCCC4 Therapeutics, Inc. | 256,468 | $675K |
| DNAGinkgo Bioworks Holdings Inc. | 109,117 | $669K |
| IRONDisc Medicine, Inc. | 10,006 | $640K |
| ANNXAnnexon, Inc. | 109,222 | $605K |
| GERNGERON CORP | 396,908 | $591K |
| FATEFATE THERAPEUTICS INC | 430,073 | $516K |
| SIGASIGA TECHNOLOGIES INC | 94,513 | $506K |
| SYRESpyre Therapeutics, Inc. | 9,546 | $482K |
| ARDXARDELYX, INC. | 79,602 | $477K |
| ALTAltimmune, Inc. | 129,846 | $400K |
| TEVATeva Pharmaceutical Industries Limited | 12,430 | $374K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 4,022 | $350K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 47,375 | $303K |
| BCYCBICYCLE THERAPEUTICS PLC | 63,305 | $294K |
| PGENPRECIGEN, INC. | 75,439 | $292K |
| SGMTSagimet Biosciences Inc. | 53,777 | $281K |
| FDMT4D Molecular Therapeutics, Inc. | 28,983 | $270K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 73,082 | $257K |
| TVTXTravere Therapeutics, Inc. | 7,356 | $219K |
| UPBUpstream Bio, Inc. | 21,154 | $190K |
| ABSIAbsci Corporation | 59,761 | $179K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 108,806 | $170K |
| RNACCartesian Therapeutics, Inc. | 23,699 | $146K |
| BTAIBioXcel Therapeutics, Inc. | 96,473 | $129K |
| MGXMetagenomi Therapeutics, Inc. | 78,636 | $105K |