| GILDGILEAD SCIENCES, INC. | 1,011,564 | $141.0M |
| SNYSanofi | 2,206,237 | $106.3M |
| REGNREGENERON PHARMACEUTICALS, INC. | 63,987 | $49.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 883,997 | $48.8M |
| INSMINSMED Inc | 138,281 | $22.6M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 67,637 | $22.4M |
| EXELEXELIXIS, INC. | 399,612 | $17.1M |
| ARGXARGENX SE | 23,247 | $17.0M |
| ROIVRoivant Sciences Ltd. | 378,656 | $10.5M |
| MRNAModerna, Inc. | 178,040 | $9.0M |
| INCYIncyte Corp. | 90,063 | $8.5M |
| ABVXAbivax SA | 75,366 | $8.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 129,499 | $8.1M |
| AXSMAxsome Therapeutics, Inc. | 47,111 | $8.0M |
| JAZZJazz Pharmaceuticals plc | 36,155 | $6.8M |
| IBRXImmunityBio, Inc. | 864,630 | $6.6M |
| TEVATeva Pharmaceutical Industries Limited | 202,298 | $6.1M |
| VKTXViking Therapeutics, Inc. | 174,263 | $5.7M |
| GMABGenmab A/S | 188,637 | $5.1M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 40,824 | $3.4M |
| TGTXTG THERAPEUTICS, INC. | 94,426 | $3.1M |
| COGTCogent Biosciences, Inc. | 74,155 | $2.9M |
| ARQTArcutis Biotherapeutics, Inc. | 119,381 | $2.8M |
| VCELVericel Corp | 76,283 | $2.5M |
| IONSIONIS PHARMACEUTICALS INC | 31,932 | $2.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 39,732 | $2.2M |
| RVMDREVOLUTION MEDICINES, INC. | 22,619 | $2.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 569,234 | $2.0M |
| GRFSGrifols S.A. | 226,631 | $1.8M |
| LGNDLigand Pharmaceuticals Incorporated | 8,211 | $1.6M |
| BBIOBridgeBio Pharma, Inc. | 21,564 | $1.6M |
| BEAMBeam Therapeutics Inc. | 66,933 | $1.6M |
| PCVXVaxcyte, Inc. | 27,324 | $1.6M |
| ADMAADMA BIOLOGICS, INC. | 175,231 | $1.6M |
| NTLAIntellia Therapeutics, Inc. | 122,861 | $1.6M |
| DMACDiaMedica Therapeutics Inc. | 226,050 | $1.5M |
| DFTXDefinium Therapeutics Inc. | 78,271 | $1.5M |
| ONCBeOne Medicines Ltd. | 4,884 | $1.5M |
| ADPTAdaptive Biotechnologies Corp | 99,889 | $1.4M |
| LQDALiquidia Corp | 34,123 | $1.3M |
| AVXLANAVEX LIFE SCIENCES CORP. | 418,640 | $1.3M |
| ARDXARDELYX, INC. | 211,320 | $1.3M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 411,385 | $1.3M |
| NUVLNuvalent, Inc. | 11,572 | $1.2M |
| STOKStoke Therapeutics, Inc. | 36,047 | $1.2M |
| ARVNARVINAS, INC. | 110,694 | $1.2M |
| HROWHARROW, INC. | 31,560 | $1.1M |
| TERNTerns Pharmaceuticals, Inc. | 20,298 | $1.1M |
| KNSAKiniksa Pharmaceuticals International, plc | 20,925 | $1.0M |
| OGNOrganon & Co. | 153,140 | $917K |
| OLMAOlema Pharmaceuticals, Inc. | 57,405 | $856K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 28,002 | $851K |
| SRRKScholar Rock Holding Corp | 16,964 | $834K |
| PGENPRECIGEN, INC. | 211,144 | $817K |
| CYTKCYTOKINETICS INC | 12,372 | $815K |
| ACADACADIA PHARMACEUTICALS INC | 36,617 | $815K |
| ESPREsperion Therapeutics, Inc. | 292,267 | $801K |
| MESOMesoblast Limited | 49,617 | $763K |
| GALTGALECTIN THERAPEUTICS INC | 267,200 | $745K |
| CCCCC4 Therapeutics, Inc. | 246,800 | $649K |
| SLSSELLAS Life Sciences Group, Inc. | 137,208 | $580K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 11,226 | $580K |
| CTMXCytomX Therapeutics, Inc. | 122,634 | $576K |
| RCKTRocket Pharmaceuticals Inc. | 156,086 | $559K |
| XERSXeris Biopharma Holdings, Inc. | 93,861 | $544K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 6,198 | $539K |
| OCULOCULAR THERAPEUTIX, INC | 62,799 | $532K |
| HUMAHumacyte Inc. | 864,463 | $524K |
| RCUSArcus Biosciences, Inc. | 22,860 | $494K |
| PVLAPALVELLA THERAPEUTICS, INC. | 3,887 | $485K |
| KODKodiak Sciences Inc. | 11,964 | $456K |
| GPCRStructure Therapeutics Inc. | 9,260 | $446K |
| ABCLAbCellera Biologics Inc. | 121,813 | $425K |
| CLYMClimb Bio, Inc. | 60,379 | $414K |
| BHVNBiohaven Ltd. | 48,801 | $413K |
| TVTXTravere Therapeutics, Inc. | 13,654 | $406K |
| MDWDMediWound Ltd. | 24,597 | $396K |
| ALGSAligos Therapeutics, Inc. | 51,500 | $383K |
| AQSTAquestive Therapeutics, Inc. | 83,213 | $345K |
| NKTRNEKTAR THERAPEUTICS | 4,550 | $327K |
| ALTAltimmune, Inc. | 103,756 | $320K |
| EVOEvotec SE | 122,346 | $306K |
| PTGXProtagonist Therapeutics, Inc | 2,793 | $294K |
| ABEOABEONA THERAPEUTICS INC. | 65,148 | $292K |
| BCAXBicara Therapeutics Inc. | 14,106 | $281K |
| QUREuniQure N.V. | 16,666 | $272K |
| CLLSCellectis S.A. | 84,345 | $267K |
| DNAGinkgo Bioworks Holdings Inc. | 43,516 | $267K |
| FOLDAMICUS THERAPEUTICS, INC. | 17,967 | $260K |
| DNLIDenali Therapeutics Inc. | 12,274 | $236K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 36,618 | $234K |
| MISTMilestone Pharmaceuticals Inc. | 193,373 | $230K |
| GERNGERON CORP | 149,857 | $223K |
| NUVBNuvation Bio Inc. | 51,140 | $219K |
| PTNPALATIN TECHNOLOGIES INC | 12,555 | $219K |
| RGCRegencell Bioscience Holdings Ltd | 8,596 | $219K |
| IXHLIncannex Healthcare Inc. | 71,178 | $214K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 9,851 | $213K |
| ANIXAnixa Biosciences Inc | 80,976 | $209K |
| CHRSCoherus Oncology, Inc. | 120,796 | $204K |
| SPRYARS Pharmaceuticals, Inc. | 25,184 | $202K |
| IMUXIMMUNIC, INC. | 169,300 | $188K |
| CMPXCompass Therapeutics, Inc. | 35,470 | $188K |
| FATEFATE THERAPEUTICS INC | 147,746 | $177K |
| RDYDR REDDYS LABORATORIES LTD | 12,668 | $175K |
| OVIDOvid Therapeutics Inc. | 69,548 | $154K |
| CMPSCOMPASS Pathways plc | 26,997 | $149K |
| CYPHCYPHERPUNK TECHNOLOGIES INC. | 162,494 | $129K |
| ZVRAZEVRA THERAPEUTICS, INC. | 13,495 | $126K |
| CADLCandel Therapeutics, Inc. | 24,702 | $121K |
| KURAKura Oncology, Inc. | 14,796 | $120K |
| SGMTSagimet Biosciences Inc. | 22,650 | $118K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 69,783 | $109K |
| MRKRMarker Therapeutics, Inc. | 83,047 | $108K |
| BDTXBlack Diamond Therapeutics, Inc. | 42,795 | $91K |
| ATAIAtai Beckley N.V. | 22,965 | $81K |
| AGENAGENUS INC | 23,720 | $79K |
| ABSIAbsci Corporation | 26,128 | $78K |
| ANNXAnnexon, Inc. | 13,214 | $73K |
| FLNAFilana Therapeutics Inc. | 40,993 | $69K |
| ONCYONCOLYTICS BIOTECH INC | 78,901 | $67K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 78,684 | $63K |
| SANASana Biotechnology, Inc. | 19,812 | $57K |
| AUTLAutolus Therapeutics plc | 37,625 | $52K |
| LCTXLineage Cell Therapeutics, Inc. | 32,205 | $51K |
| TTRXTurn Therapeutics Inc. | 13,300 | $43K |
| ALDXAldeyra Therapeutics, Inc. | 23,416 | $40K |
| CNTNCanton Strategic Holdings, Inc. | 11,200 | $37K |
| ORGOOrganogenesis Holdings Inc. | 14,939 | $35K |
| INOINOVIO PHARMACEUTICALS, INC. | 18,576 | $32K |
| OPKOPKO HEALTH, INC. | 28,158 | $32K |
| DAREDare Bioscience, Inc. | 14,639 | $27K |
| OCGNOcugen, Inc. | 14,220 | $26K |
| MGXMetagenomi Therapeutics, Inc. | 16,834 | $23K |
| CTXRCitius Pharmaceuticals, Inc. | 25,045 | $23K |
| PLXProtalix BioTherapeutics, Inc. | 10,291 | $22K |
| TLSATiziana Life Sciences Ltd | 10,500 | $12K |
| IMMPImmutep Limited | 33,982 | $12K |
| AEONAEON Biopharma, Inc. | 11,507 | $11K |
| JSPRJasper Therapeutics Inc. | 12,250 | $11K |
| SGMOQSANGAMO THERAPEUTICS, INC | 33,809 | $8K |
| HOWLWerewolf Therapeutics, Inc. | 10,000 | $8K |
| OTLKOutlook Therapeutics, Inc. | 33,627 | $7K |
| GRMLGreenland Mines Ltd | 19,000 | $6K |
| SILOSilo Pharma, Inc. | 12,534 | $5K |
| CUECue Biopharma, Inc. | 15,590 | $4K |
| QNCXQuince Therapeutics, Inc. | 10,933 | $1K |