| GILDGILEAD SCIENCES, INC. | 483,233 | $64.9M |
| SNYSanofi | 812,970 | $38.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 73,643 | $23.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 223,097 | $12.0M |
| ARGXARGENX SE | 16,809 | $11.6M |
| ARDXARDELYX, INC. | 1,858,891 | $10.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 12,763 | $9.4M |
| TEVATeva Pharmaceutical Industries Limited | 321,219 | $9.2M |
| SLSSELLAS Life Sciences Group, Inc. | 1,675,077 | $7.3M |
| INSMINSMED Inc | 41,406 | $6.0M |
| ESPREsperion Therapeutics, Inc. | 2,135,741 | $5.9M |
| JAZZJazz Pharmaceuticals plc | 18,152 | $3.3M |
| MRNAModerna, Inc. | 42,835 | $2.1M |
| IONSIONIS PHARMACEUTICALS INC | 26,723 | $1.9M |
| ONCBeOne Medicines Ltd. | 6,465 | $1.8M |
| ACADACADIA PHARMACEUTICALS INC | 76,902 | $1.6M |
| BBIOBridgeBio Pharma, Inc. | 21,251 | $1.5M |
| EXELEXELIXIS, INC. | 31,428 | $1.3M |
| VKTXViking Therapeutics, Inc. | 32,024 | $1.0M |
| VCELVericel Corp | 29,602 | $869K |
| INCYIncyte Corp. | 9,272 | $837K |
| NTLAIntellia Therapeutics, Inc. | 53,781 | $665K |
| TERNTerns Pharmaceuticals, Inc. | 12,567 | $665K |
| TGTXTG THERAPEUTICS, INC. | 20,422 | $648K |
| CYTKCYTOKINETICS INC | 9,191 | $574K |
| COGTCogent Biosciences, Inc. | 14,832 | $535K |
| ABVXAbivax SA | 4,070 | $417K |
| NUVLNuvalent, Inc. | 3,891 | $376K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 4,918 | $373K |
| IBRXImmunityBio, Inc. | 50,171 | $370K |
| ROIVRoivant Sciences Ltd. | 12,850 | $341K |
| ARQTArcutis Biotherapeutics, Inc. | 14,033 | $298K |
| PTGXProtagonist Therapeutics, Inc | 2,923 | $289K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 5,292 | $287K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 5,089 | $252K |
| AXSMAxsome Therapeutics, Inc. | 1,493 | $233K |
| LGNDLigand Pharmaceuticals Incorporated | 1,134 | $222K |
| APGEApogee Therapeutics, Inc. | 2,845 | $221K |
| PCVXVaxcyte, Inc. | 3,571 | $190K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 19,409 | $180K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 2,896 | $167K |
| BTAIBioXcel Therapeutics, Inc. | 131,789 | $166K |
| FENCFENNEC PHARMACEUTICALS INC. | 24,952 | $147K |
| SRRKScholar Rock Holding Corp | 3,350 | $143K |
| GERNGERON CORP | 88,952 | $125K |
| GMABGenmab A/S | 4,691 | $121K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 4,044 | $119K |
| IRONDisc Medicine, Inc. | 1,627 | $98K |
| SPRYARS Pharmaceuticals, Inc. | 11,142 | $90K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 1,076 | $87K |
| ALTAltimmune, Inc. | 25,869 | $78K |
| GLSIGreenwich LifeSciences, Inc. | 3,200 | $71K |
| STOKStoke Therapeutics, Inc. | 2,120 | $70K |
| RGNXREGENXBIO Inc. | 8,470 | $66K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 21,756 | $64K |
| ABSIAbsci Corporation | 19,359 | $54K |
| BEAMBeam Therapeutics Inc. | 2,307 | $51K |
| APLSApellis Pharmaceuticals, Inc. | 2,984 | $51K |
| OCULOCULAR THERAPEUTIX, INC | 6,348 | $48K |
| INVAInnoviva, Inc. | 2,054 | $47K |
| LQDALiquidia Corp | 1,275 | $45K |
| HROWHARROW, INC. | 1,269 | $43K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 11,686 | $41K |
| RVMDREVOLUTION MEDICINES, INC. | 426 | $39K |
| QUREuniQure N.V. | 2,657 | $39K |
| IMVTImmunovant, Inc. | 1,481 | $36K |
| OLMAOlema Pharmaceuticals, Inc. | 2,455 | $34K |
| XERSXeris Biopharma Holdings, Inc. | 6,207 | $34K |
| ZVRAZEVRA THERAPEUTICS, INC. | 3,248 | $30K |
| ADMAADMA BIOLOGICS, INC. | 2,836 | $26K |
| CGTXCOGNITION THERAPEUTICS INC | 35,481 | $26K |
| SANASana Biotechnology, Inc. | 9,168 | $25K |
| CLNNClene Inc. | 5,000 | $24K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 30,062 | $24K |
| NUVBNuvation Bio Inc. | 5,200 | $22K |
| NKTRNEKTAR THERAPEUTICS | 300 | $21K |
| ATAIAtai Beckley N.V. | 6,029 | $20K |
| LYELLyell Immunopharma, Inc. | 1,025 | $20K |
| OGNOrganon & Co. | 3,421 | $20K |
| ADPTAdaptive Biotechnologies Corp | 1,609 | $20K |
| OPKOPKO HEALTH, INC. | 16,675 | $19K |
| SPROSpero Therapeutics, Inc. | 7,678 | $18K |
| ANNXAnnexon, Inc. | 3,565 | $18K |
| TVTXTravere Therapeutics, Inc. | 632 | $17K |
| SMMTSummit Therapeutics Inc. | 1,036 | $17K |
| AQSTAquestive Therapeutics, Inc. | 4,150 | $17K |
| MISTMilestone Pharmaceuticals Inc. | 16,000 | $17K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 530 | $16K |
| GPCRStructure Therapeutics Inc. | 341 | $16K |
| VRDNViridian Therapeutics, Inc.\DE | 511 | $14K |
| ALMSALUMIS INC. | 544 | $13K |
| SLNSilence Therapeutics Plc | 2,500 | $12K |
| ZYMEZymeworks Inc. | 465 | $11K |
| HUMAHumacyte Inc. | 16,507 | $11K |
| ANIXAnixa Biosciences Inc | 4,330 | $11K |
| KNSAKiniksa Pharmaceuticals International, plc | 237 | $11K |
| ALVOAlvotech | 3,370 | $10K |
| ANIPANI PHARMACEUTICALS INC | 141 | $10K |
| BHVNBiohaven Ltd. | 1,187 | $10K |
| AVXLANAVEX LIFE SCIENCES CORP. | 3,470 | $10K |
| ATOSATOSSA THERAPEUTICS, INC. | 2,061 | $10K |
| RCKTRocket Pharmaceuticals Inc. | 2,310 | $9K |
| LENZLENZ Therapeutics, Inc. | 947 | $8K |
| CNTACentessa Pharmaceuticals plc | 277 | $8K |
| FOLDAMICUS THERAPEUTICS, INC. | 528 | $8K |
| OVIDOvid Therapeutics Inc. | 2,925 | $7K |
| LCTXLineage Cell Therapeutics, Inc. | 4,500 | $7K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 189 | $5K |
| OCGNOcugen, Inc. | 2,888 | $5K |
| IVAInventiva S.A. | 881 | $5K |
| ABCLAbCellera Biologics Inc. | 1,507 | $5K |
| CADLCandel Therapeutics, Inc. | 1,020 | $5K |
| SCLXSCILEX HOLDING CO | 752 | $5K |
| GRFSGrifols S.A. | 608 | $5K |
| FLGTFulgent Genetics Inc. | 289 | $5K |
| MESOMesoblast Limited | 300 | $4K |
| ABEOABEONA THERAPEUTICS INC. | 1,000 | $4K |
| BCAXBicara Therapeutics Inc. | 229 | $4K |
| CATXPerspective Therapeutics, Inc. | 1,021 | $4K |
| ONCYONCOLYTICS BIOTECH INC | 4,278 | $4K |
| ABUSArbutus Biopharma Corp | 830 | $4K |
| RLAYRelay Therapeutics, Inc. | 350 | $3K |
| QNTMQuantum Biopharma Ltd. | 700 | $3K |
| PTCTPTC THERAPEUTICS, INC. | 49 | $3K |
| DFTXDefinium Therapeutics Inc. | 180 | $3K |
| ORMPORAMED PHARMACEUTICALS INC. | 933 | $3K |
| PTNPALATIN TECHNOLOGIES INC | 150 | $3K |
| NBPNovaBridge Biosciences | 1,104 | $3K |
| IVVDInvivyd, Inc. | 2,036 | $3K |
| DRTSAlpha Tau Medical Ltd. | 400 | $3K |
| MAZEMaze Therapeutics, Inc. | 90 | $3K |
| NNVCNANOVIRICIDES, INC. | 3,000 | $3K |
| GALTGALECTIN THERAPEUTICS INC | 1,000 | $3K |
| ORKAOruka Therapeutics, Inc. | 59 | $3K |
| PVLAPALVELLA THERAPEUTICS, INC. | 23 | $3K |
| SLNOSOLENO THERAPEUTICS INC | 82 | $2K |
| TNGXTango Therapeutics, Inc. | 122 | $2K |
| CTMXCytomX Therapeutics, Inc. | 500 | $2K |
| BCYCBICYCLE THERAPEUTICS PLC | 500 | $2K |
| CLDXCelldex Therapeutics, Inc. | 70 | $2K |
| ENVBEnveric Biosciences, Inc. | 1,000 | $2K |
| CLYMClimb Bio, Inc. | 266 | $2K |
| IFRXInflaRx N.V. | 1,784 | $2K |
| ARVNARVINAS, INC. | 156 | $2K |
| RCUSArcus Biosciences, Inc. | 67 | $1K |
| TLSATiziana Life Sciences Ltd | 1,027 | $1K |
| KALVKalVista Pharmaceuticals, Inc. | 63 | $1K |
| INABIN8BIO, INC. | 768 | $1K |
| PDSBPDS Biotechnology Corp | 2,000 | $1K |
| FATEFATE THERAPEUTICS INC | 900 | $1K |
| MLTXMoonLake Immunotherapeutics | 52 | $901 |
| BDTXBlack Diamond Therapeutics, Inc. | 428 | $869 |
| FLNAFilana Therapeutics Inc. | 462 | $772 |
| SVRASavara Inc | 146 | $750 |
| NRSNNeuroSense Therapeutics Ltd. | 1,000 | $731 |
| DNLIDenali Therapeutics Inc. | 39 | $708 |
| CCCCC4 Therapeutics, Inc. | 278 | $670 |
| PGENPRECIGEN, INC. | 181 | $664 |
| MGXMetagenomi Therapeutics, Inc. | 500 | $660 |
| MANEVeradermics Incorporated | 10 | $655 |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 71 | $618 |
| LXRXLEXICON PHARMACEUTICALS, INC. | 356 | $587 |
| OTLKOutlook Therapeutics, Inc. | 2,500 | $520 |
| ACOGAlpha Cognition Inc. | 100 | $508 |
| TNXPTonix Pharmaceuticals Holding Corp. | 35 | $451 |
| PBYIPUMA BIOTECHNOLOGY, INC. | 68 | $413 |
| TPSTTempest Therapeutics, Inc. | 239 | $413 |
| TVRDTvardi Therapeutics, Inc. | 128 | $406 |
| INOINOVIO PHARMACEUTICALS, INC. | 240 | $386 |
| RNAAtrium Therapeutics Inc. | 29 | $384 |
| TAOXTAO Synergies Inc. | 70 | $365 |
| ATNMActinium Pharmaceuticals, Inc. | 351 | $362 |
| BCABBioAtla, Inc. | 2,000 | $306 |
| VYGRVoyager Therapeutics, Inc. | 75 | $297 |
| LONALeonaBio, Inc. | 33 | $296 |
| LGVNLongeveron Inc. | 300 | $276 |
| EVOEvotec SE | 100 | $242 |
| BMEABiomea Fusion, Inc. | 128 | $169 |
| PROKPROKIDNEY CORP. | 100 | $160 |
| XFORX4 Pharmaceuticals, Inc | 38 | $154 |
| VERUVERU INC. | 66 | $138 |
| CELUCelularity Inc. | 82 | $100 |
| CUECue Biopharma, Inc. | 400 | $96 |
| CRDFCardiff Oncology, Inc. | 50 | $78 |
| DNAGinkgo Bioworks Holdings Inc. | 12 | $71 |
| VTGNVistagen Therapeutics, Inc. | 114 | $65 |
| JSPRJasper Therapeutics Inc. | 50 | $53 |
| DAWNDay One Biopharmaceuticals, Inc. | 2 | $43 |
| ASRTAssertio Holdings, Inc. | 2 | $39 |
| SLXNSilexion Therapeutics Corp | 26 | $32 |
| JBIOJade Biosciences, Inc. | 2 | $27 |
| PPBTPURPLE BIOTECH LTD. | 5 | $20 |
| PCSAProcessa Pharmaceuticals, Inc. | 7 | $17 |
| TENXTENAX THERAPEUTICS, INC. | 1 | $15 |
| QNCXQuince Therapeutics, Inc. | 133 | $12 |
| INKTMiNK Therapeutics, Inc. | 1 | $11 |
| CLRBCellectar Biosciences, Inc. | 3 | $8 |
| AYTUAYTU BIOPHARMA, INC | 1 | $3 |
| HURATuHURA Biosciences, Inc./NV | 1 | $2 |