| ARGXARGENX SE | 2,541,732 | $1.85B |
| BBIOBridgeBio Pharma, Inc. | 13,179,013 | $978.6M |
| PCVXVaxcyte, Inc. | 16,575,875 | $960.2M |
| RVMDREVOLUTION MEDICINES, INC. | 9,766,496 | $949.5M |
| PTCTPTC THERAPEUTICS, INC. | 7,193,433 | $490.0M |
| TVTXTravere Therapeutics, Inc. | 11,419,586 | $339.2M |
| PTGXProtagonist Therapeutics, Inc | 2,891,527 | $304.9M |
| GILDGILEAD SCIENCES, INC. | 1,972,639 | $274.9M |
| GPCRStructure Therapeutics Inc. | 5,354,981 | $258.3M |
| SLNOSOLENO THERAPEUTICS INC | 7,099,328 | $237.6M |
| COGTCogent Biosciences, Inc. | 5,965,125 | $229.6M |
| LGNDLigand Pharmaceuticals Incorporated | 1,009,891 | $201.6M |
| APGEApogee Therapeutics, Inc. | 2,360,596 | $198.8M |
| REGNREGENERON PHARMACEUTICALS, INC. | 209,248 | $161.6M |
| BHVNBiohaven Ltd. | 17,534,612 | $148.2M |
| TEVATeva Pharmaceutical Industries Limited | 4,816,657 | $145.1M |
| CNTACentessa Pharmaceuticals plc | 3,492,977 | $138.7M |
| NUVLNuvalent, Inc. | 1,237,779 | $126.8M |
| SRRKScholar Rock Holding Corp | 2,236,837 | $109.9M |
| OLMAOlema Pharmaceuticals, Inc. | 7,108,488 | $106.0M |
| ABVXAbivax SA | 878,829 | $98.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,436,990 | $90.1M |
| ROIVRoivant Sciences Ltd. | 3,095,448 | $85.8M |
| MAZEMaze Therapeutics, Inc. | 2,858,876 | $85.3M |
| SYRESpyre Therapeutics, Inc. | 1,656,164 | $83.6M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 918,153 | $79.9M |
| TERNTerns Pharmaceuticals, Inc. | 1,470,057 | $77.5M |
| RLMDRELMADA THERAPEUTICS, INC. | 11,063,862 | $76.9M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 2,258,984 | $72.3M |
| INSMINSMED Inc | 419,304 | $68.6M |
| DFTXDefinium Therapeutics Inc. | 3,556,041 | $67.2M |
| BCAXBicara Therapeutics Inc. | 3,339,218 | $66.4M |
| MLTXMoonLake Immunotherapeutics | 3,451,628 | $64.3M |
| DMRADamora Therapeutics, Inc. | 2,362,696 | $61.4M |
| STOKStoke Therapeutics, Inc. | 1,612,781 | $52.5M |
| KODKodiak Sciences Inc. | 1,325,457 | $50.5M |
| ARDXARDELYX, INC. | 8,371,234 | $50.1M |
| TNGXTango Therapeutics, Inc. | 2,394,972 | $50.1M |
| FDMT4D Molecular Therapeutics, Inc. | 5,247,151 | $48.9M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 147,089 | $48.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 857,010 | $48.4M |
| ALMSALUMIS INC. | 2,124,408 | $46.8M |
| IMMXImmix Biopharma, Inc. | 4,802,002 | $43.7M |
| ARQTArcutis Biotherapeutics, Inc. | 1,854,566 | $43.7M |
| JBIOJade Biosciences, Inc. | 3,105,669 | $43.6M |
| IVVDInvivyd, Inc. | 33,094,330 | $42.9M |
| EXELEXELIXIS, INC. | 913,802 | $39.2M |
| BIOABioAge Labs, Inc. | 2,094,270 | $36.6M |
| SNYSanofi | 642,277 | $30.9M |
| FBRXForte Biosciences, Inc. | 1,188,060 | $30.8M |
| TENXTENAX THERAPEUTICS, INC. | 1,815,474 | $29.1M |
| SLDBSolid Biosciences Inc. | 4,010,695 | $28.9M |
| CAMPCamp4 Therapeutics Corp | 6,307,636 | $27.9M |
| GRFSGrifols S.A. | 3,290,089 | $26.4M |
| OVIDOvid Therapeutics Inc. | 10,714,000 | $23.7M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 849,309 | $23.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 481,023 | $23.2M |
| CYTKCYTOKINETICS INC | 282,121 | $18.6M |
| IMCRImmunocore Holdings plc | 594,712 | $17.9M |
| PMNProMIS Neurosciences Inc. | 1,292,757 | $16.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,073,865 | $15.5M |
| NBPNovaBridge Biosciences | 6,032,650 | $14.8M |
| DAWNDay One Biopharmaceuticals, Inc. | 546,428 | $11.7M |
| APLSApellis Pharmaceuticals, Inc. | 252,130 | $10.1M |
| ANIPANI PHARMACEUTICALS INC | 109,552 | $8.4M |
| MRNAModerna, Inc. | 159,372 | $8.1M |
| INOINOVIO PHARMACEUTICALS, INC. | 3,308,406 | $5.8M |
| IONSIONIS PHARMACEUTICALS INC | 68,191 | $5.1M |
| JAZZJazz Pharmaceuticals plc | 24,000 | $4.5M |
| GERNGERON CORP | 2,218,196 | $3.3M |
| AXSMAxsome Therapeutics, Inc. | 19,052 | $3.2M |
| PTNPALATIN TECHNOLOGIES INC | 140,000 | $2.4M |
| BEAMBeam Therapeutics Inc. | 93,253 | $2.2M |
| TGTXTG THERAPEUTICS, INC. | 64,357 | $2.1M |
| INCYIncyte Corp. | 19,902 | $1.9M |
| RNAAtrium Therapeutics Inc. | 139,973 | $1.9M |
| XERSXeris Biopharma Holdings, Inc. | 295,489 | $1.7M |
| LBRXLB PHARMACEUTICALS INC | 65,429 | $1.6M |
| KTTAPasithea Therapeutics Corp. | 2,100,000 | $1.6M |
| VKTXViking Therapeutics, Inc. | 45,700 | $1.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 16,500 | $1.4M |
| IBRXImmunityBio, Inc. | 157,439 | $1.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 23,254 | $1.2M |
| DNLIDenali Therapeutics Inc. | 60,028 | $1.2M |
| ACADACADIA PHARMACEUTICALS INC | 51,410 | $1.1M |
| MPLTMapLight Therapeutics, Inc. | 54,752 | $1.1M |
| LQDALiquidia Corp | 27,971 | $1.1M |
| SIGASIGA TECHNOLOGIES INC | 187,521 | $1.0M |
| RCUSArcus Biosciences, Inc. | 42,338 | $916K |
| ADMAADMA BIOLOGICS, INC. | 98,261 | $884K |
| CADLCandel Therapeutics, Inc. | 171,978 | $845K |
| IMVTImmunovant, Inc. | 33,731 | $838K |
| CLDXCelldex Therapeutics, Inc. | 25,642 | $814K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 23,797 | $805K |
| NKTRNEKTAR THERAPEUTICS | 10,729 | $771K |
| IRONDisc Medicine, Inc. | 11,555 | $739K |
| VCELVericel Corp | 21,659 | $697K |
| OGNOrganon & Co. | 115,640 | $692K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 22,600 | $687K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 220,309 | $675K |
| ADPTAdaptive Biotechnologies Corp | 46,900 | $651K |
| INVAInnoviva, Inc. | 27,858 | $649K |
| NTLAIntellia Therapeutics, Inc. | 47,957 | $615K |
| NRIXNurix Therapeutics, Inc. | 39,400 | $610K |
| ORKAOruka Therapeutics, Inc. | 12,100 | $594K |
| OCULOCULAR THERAPEUTIX, INC | 68,500 | $581K |
| VRDNViridian Therapeutics, Inc.\DE | 27,472 | $537K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 141,672 | $498K |
| HROWHARROW, INC. | 13,500 | $476K |
| NUVBNuvation Bio Inc. | 108,400 | $463K |
| HRMYHarmony Biosciences Holdings, Inc. | 16,402 | $459K |
| ZYMEZymeworks Inc. | 18,200 | $456K |
| PVLAPALVELLA THERAPEUTICS, INC. | 3,600 | $450K |
| ELVNEnliven Therapeutics, Inc. | 11,000 | $431K |
| ANABANAPTYSBIO, INC | 7,464 | $414K |
| PGENPRECIGEN, INC. | 89,000 | $344K |
| ANNXAnnexon, Inc. | 59,100 | $328K |
| CMPXCompass Therapeutics, Inc. | 55,600 | $294K |
| ATAIAtai Beckley N.V. | 79,400 | $281K |
| QUREuniQure N.V. | 16,900 | $276K |
| ABUSArbutus Biopharma Corp | 60,900 | $274K |
| CGEMCullinan Therapeutics, Inc. | 18,528 | $263K |
| ARVNARVINAS, INC. | 23,365 | $247K |
| SVRASavara Inc | 45,200 | $247K |
| OPKOPKO HEALTH, INC. | 206,314 | $236K |
| CTMXCytomX Therapeutics, Inc. | 46,700 | $220K |
| KALVKalVista Pharmaceuticals, Inc. | 10,900 | $220K |
| KURAKura Oncology, Inc. | 24,922 | $202K |
| ORICOric Pharmaceuticals, Inc. | 14,400 | $182K |
| SPRYARS Pharmaceuticals, Inc. | 21,600 | $174K |
| SANASana Biotechnology, Inc. | 58,189 | $167K |
| DNAGinkgo Bioworks Holdings Inc. | 14,534 | $89K |