| GILDGILEAD SCIENCES, INC. | 3,190,339 | $444.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 323,338 | $249.7M |
| INCYIncyte Corp. | 582,368 | $54.8M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 89,619 | $29.6M |
| TEVATeva Pharmaceutical Industries Limited | 961,140 | $28.8M |
| MRNAModerna, Inc. | 490,088 | $24.6M |
| INSMINSMED Inc | 116,456 | $19.0M |
| PTCTPTC THERAPEUTICS, INC. | 227,059 | $15.5M |
| ARGXARGENX SE | 20,379 | $14.9M |
| CYTKCYTOKINETICS INC | 221,999 | $14.6M |
| IONSIONIS PHARMACEUTICALS INC | 185,967 | $14.0M |
| TVTXTravere Therapeutics, Inc. | 396,853 | $11.8M |
| AXSMAxsome Therapeutics, Inc. | 68,453 | $11.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 151,046 | $9.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 148,182 | $8.4M |
| ANABANAPTYSBIO, INC | 125,717 | $7.1M |
| SLNOSOLENO THERAPEUTICS INC | 174,204 | $5.8M |
| UPBUpstream Bio, Inc. | 640,326 | $5.8M |
| SNYSanofi | 107,689 | $5.2M |
| TGTXTG THERAPEUTICS, INC. | 106,344 | $3.6M |
| RVMDREVOLUTION MEDICINES, INC. | 32,791 | $3.2M |
| EXELEXELIXIS, INC. | 65,978 | $2.8M |
| BBIOBridgeBio Pharma, Inc. | 32,708 | $2.4M |
| INVAInnoviva, Inc. | 101,608 | $2.4M |
| ABVXAbivax SA | 15,426 | $1.7M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 14,307 | $1.2M |
| RDYDR REDDYS LABORATORIES LTD | 78,293 | $1.1M |
| FLGTFulgent Genetics Inc. | 65,174 | $1.0M |
| ACADACADIA PHARMACEUTICALS INC | 44,008 | $977K |
| ARVNARVINAS, INC. | 89,147 | $958K |
| ZYMEZymeworks Inc. | 37,777 | $940K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 246,757 | $753K |
| KURAKura Oncology, Inc. | 89,032 | $736K |
| LGNDLigand Pharmaceuticals Incorporated | 3,455 | $690K |
| STOKStoke Therapeutics, Inc. | 20,521 | $686K |
| SLNSilence Therapeutics Plc | 122,834 | $640K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 65,070 | $632K |
| JAZZJazz Pharmaceuticals plc | 3,286 | $621K |
| NTLAIntellia Therapeutics, Inc. | 48,259 | $614K |
| KROSKeros Therapeutics, Inc. | 53,986 | $599K |
| VKTXViking Therapeutics, Inc. | 18,119 | $592K |
| ARDXARDELYX, INC. | 93,931 | $561K |
| ABCLAbCellera Biologics Inc. | 143,472 | $499K |
| ALTAltimmune, Inc. | 154,365 | $476K |
| TRDAEntrada Therapeutics, Inc. | 38,137 | $472K |
| RGNXREGENXBIO Inc. | 55,830 | $467K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 7,301 | $400K |
| BHVNBiohaven Ltd. | 45,115 | $379K |
| AVXLANAVEX LIFE SCIENCES CORP. | 107,856 | $330K |
| FOLDAMICUS THERAPEUTICS, INC. | 21,517 | $311K |
| SLDBSolid Biosciences Inc. | 39,511 | $284K |
| ROIVRoivant Sciences Ltd. | 9,720 | $273K |
| OPKOPKO HEALTH, INC. | 238,281 | $273K |
| RADXRadiopharm Theranostics Limited | 61,372 | $265K |
| KNSAKiniksa Pharmaceuticals International, plc | 5,157 | $248K |
| APLSApellis Pharmaceuticals, Inc. | 5,944 | $239K |
| PCVXVaxcyte, Inc. | 3,992 | $232K |
| ONCBeOne Medicines Ltd. | 707 | $208K |
| SANASana Biotechnology, Inc. | 72,194 | $205K |
| LENZLENZ Therapeutics, Inc. | 21,894 | $204K |
| VCELVericel Corp | 6,386 | $203K |
| PTGXProtagonist Therapeutics, Inc | 1,907 | $201K |
| ABSIAbsci Corporation | 64,508 | $196K |
| XERSXeris Biopharma Holdings, Inc. | 31,175 | $183K |
| IMAImageneBio, Inc. | 34,884 | $166K |
| CHRSCoherus Oncology, Inc. | 91,895 | $158K |
| OGNOrganon & Co. | 22,429 | $134K |
| ESPREsperion Therapeutics, Inc. | 48,141 | $132K |
| VYGRVoyager Therapeutics, Inc. | 33,202 | $129K |
| ORGOOrganogenesis Holdings Inc. | 51,963 | $122K |
| FATEFATE THERAPEUTICS INC | 97,684 | $116K |
| RZLTRezolute, Inc. | 36,939 | $113K |
| ALECAlector, Inc. | 48,523 | $105K |
| NUVBNuvation Bio Inc. | 23,724 | $101K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 27,484 | $98K |
| TLSATiziana Life Sciences Ltd | 62,437 | $76K |
| SIGASIGA TECHNOLOGIES INC | 13,385 | $71K |
| BDTXBlack Diamond Therapeutics, Inc. | 26,421 | $57K |
| AGENAGENUS INC | 14,888 | $50K |
| PRLDPrelude Therapeutics Inc | 13,652 | $48K |
| CCCCC4 Therapeutics, Inc. | 13,629 | $36K |
| GERNGERON CORP | 22,284 | $33K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 33,381 | $26K |
| ALXOALX ONCOLOGY HOLDINGS INC | 10,105 | $20K |
| FLNAFilana Therapeutics Inc. | 10,000 | $17K |