| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 212,287 | $11.7M |
| APLSApellis Pharmaceuticals, Inc. | 33,573 | $1.4M |
| PTCTPTC THERAPEUTICS, INC. | 18,169 | $1.2M |
| KURAKura Oncology, Inc. | 132,174 | $1.1M |
| FOLDAMICUS THERAPEUTICS, INC. | 70,670 | $1.0M |
| ARGXARGENX SE | 1,247 | $911K |
| SNYSanofi | 17,301 | $834K |
| TEVATeva Pharmaceutical Industries Limited | 25,671 | $773K |
| BMRNBIOMARIN PHARMACEUTICAL INC | 12,426 | $702K |
| INSMINSMED Inc | 3,698 | $605K |
| BBIOBridgeBio Pharma, Inc. | 8,057 | $598K |
| INCYIncyte Corp. | 5,289 | $498K |
| EXELEXELIXIS, INC. | 11,590 | $497K |
| ADPTAdaptive Biotechnologies Corp | 33,863 | $470K |
| GILDGILEAD SCIENCES, INC. | 3,207 | $438K |
| REGNREGENERON PHARMACEUTICALS, INC. | 528 | $405K |
| CMPXCompass Therapeutics, Inc. | 76,493 | $405K |
| SPRYARS Pharmaceuticals, Inc. | 43,665 | $351K |
| ARDXARDELYX, INC. | 53,820 | $322K |
| NUVLNuvalent, Inc. | 3,060 | $313K |
| TVTXTravere Therapeutics, Inc. | 10,518 | $312K |
| ABUSArbutus Biopharma Corp | 69,089 | $311K |
| ANNXAnnexon, Inc. | 54,484 | $302K |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 875 | $289K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 2,562 | $223K |
| SMMTSummit Therapeutics Inc. | 11,533 | $219K |
| BEAMBeam Therapeutics Inc. | 8,997 | $214K |
| XERSXeris Biopharma Holdings, Inc. | 36,807 | $213K |
| ACADACADIA PHARMACEUTICALS INC | 8,993 | $200K |
| OLMAOlema Pharmaceuticals, Inc. | 13,376 | $199K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 51,563 | $181K |
| GERNGERON CORP | 111,075 | $166K |
| ADMAADMA BIOLOGICS, INC. | 13,387 | $121K |
| ATAIAtai Beckley N.V. | 29,045 | $103K |
| CTMXCytomX Therapeutics, Inc. | 21,803 | $102K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 28,520 | $88K |
| IBRXImmunityBio, Inc. | 11,139 | $85K |
| RCKTRocket Pharmaceuticals Inc. | 20,488 | $73K |
| PGENPRECIGEN, INC. | 18,664 | $72K |
| SANASana Biotechnology, Inc. | 12,383 | $36K |
| APTOFAptose Biosciences Inc. | 19,761 | $33K |
| PTIXProtagenic Therapeutics, Inc.\new | 41,783 | $28K |
| SYBXSYNLOGIC, INC. | 23,763 | $14K |
| CLSDQClearside Biomedical, Inc. | 27,136 | $8K |