| GILDGILEAD SCIENCES, INC. | 7,722,929 | $1.08B |
| REGNREGENERON PHARMACEUTICALS, INC. | 513,060 | $396.3M |
| JAZZJazz Pharmaceuticals plc | 1,895,215 | $358.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 3,802,930 | $214.8M |
| ROIVRoivant Sciences Ltd. | 7,475,866 | $207.0M |
| INCYIncyte Corp. | 1,975,544 | $185.9M |
| EXELEXELIXIS, INC. | 4,299,597 | $184.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 2,586,767 | $142.8M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 384,205 | $127.1M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 2,307,030 | $119.2M |
| MRNAModerna, Inc. | 2,132,167 | $108.2M |
| INVAInnoviva, Inc. | 4,436,427 | $103.4M |
| TEVATeva Pharmaceutical Industries Limited | 2,864,594 | $86.2M |
| LGNDLigand Pharmaceuticals Incorporated | 425,230 | $84.9M |
| RVMDREVOLUTION MEDICINES, INC. | 844,614 | $82.1M |
| RDYDR REDDYS LABORATORIES LTD | 5,323,248 | $73.7M |
| ACADACADIA PHARMACEUTICALS INC | 3,155,160 | $70.2M |
| TERNTerns Pharmaceuticals, Inc. | 1,247,845 | $65.8M |
| INSMINSMED Inc | 400,900 | $65.5M |
| PTCTPTC THERAPEUTICS, INC. | 890,715 | $60.7M |
| APLSApellis Pharmaceuticals, Inc. | 1,338,995 | $53.7M |
| PTGXProtagonist Therapeutics, Inc | 508,103 | $53.5M |
| DNLIDenali Therapeutics Inc. | 2,692,175 | $51.7M |
| BEAMBeam Therapeutics Inc. | 2,154,575 | $51.3M |
| ADMAADMA BIOLOGICS, INC. | 5,005,481 | $45.1M |
| BBIOBridgeBio Pharma, Inc. | 561,945 | $41.7M |
| ANIPANI PHARMACEUTICALS INC | 531,190 | $40.8M |
| KNSAKiniksa Pharmaceuticals International, plc | 811,922 | $39.1M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,151,614 | $38.9M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 608,531 | $38.1M |
| TGTXTG THERAPEUTICS, INC. | 1,084,855 | $36.0M |
| CLDXCelldex Therapeutics, Inc. | 1,059,534 | $33.6M |
| STOKStoke Therapeutics, Inc. | 989,936 | $32.2M |
| RCUSArcus Biosciences, Inc. | 1,426,223 | $30.8M |
| NTLAIntellia Therapeutics, Inc. | 2,318,110 | $29.7M |
| ZYMEZymeworks Inc. | 1,139,135 | $28.5M |
| ARGXARGENX SE | 38,794 | $28.3M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 325,440 | $27.3M |
| VCELVericel Corp | 844,755 | $27.2M |
| ELVNEnliven Therapeutics, Inc. | 681,715 | $26.7M |
| IRONDisc Medicine, Inc. | 394,447 | $25.2M |
| PCVXVaxcyte, Inc. | 375,772 | $21.8M |
| HROWHARROW, INC. | 579,520 | $20.4M |
| IONSIONIS PHARMACEUTICALS INC | 267,215 | $20.1M |
| OGNOrganon & Co. | 3,265,280 | $19.6M |
| ORICOric Pharmaceuticals, Inc. | 1,471,290 | $18.6M |
| VKTXViking Therapeutics, Inc. | 542,516 | $17.7M |
| DAWNDay One Biopharmaceuticals, Inc. | 819,371 | $17.6M |
| ONCBeOne Medicines Ltd. | 56,879 | $16.9M |
| OLMAOlema Pharmaceuticals, Inc. | 1,082,434 | $16.1M |
| SIGASIGA TECHNOLOGIES INC | 2,702,724 | $14.5M |
| CGEMCullinan Therapeutics, Inc. | 906,028 | $12.9M |
| NRIXNurix Therapeutics, Inc. | 780,696 | $12.1M |
| KODKodiak Sciences Inc. | 315,400 | $12.0M |
| KURAKura Oncology, Inc. | 1,425,945 | $11.6M |
| FLGTFulgent Genetics Inc. | 671,664 | $10.7M |
| VRDNViridian Therapeutics, Inc.\DE | 529,763 | $10.4M |
| TNGXTango Therapeutics, Inc. | 489,348 | $10.2M |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 2,645,702 | $9.3M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 1,436,106 | $9.2M |
| CTMXCytomX Therapeutics, Inc. | 1,930,920 | $9.1M |
| NUVBNuvation Bio Inc. | 2,052,691 | $8.8M |
| RGNXREGENXBIO Inc. | 1,010,381 | $8.5M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 782,603 | $7.6M |
| SLDBSolid Biosciences Inc. | 956,135 | $6.9M |
| ORGOOrganogenesis Holdings Inc. | 2,891,006 | $6.9M |
| CYTKCYTOKINETICS INC | 94,503 | $6.2M |
| SNYSanofi | 121,790 | $5.9M |
| ORKAOruka Therapeutics, Inc. | 113,009 | $5.5M |
| OCULOCULAR THERAPEUTIX, INC | 649,756 | $5.5M |
| ZVRAZEVRA THERAPEUTICS, INC. | 554,802 | $5.2M |
| ARVNARVINAS, INC. | 485,764 | $5.1M |
| ANNXAnnexon, Inc. | 924,078 | $5.1M |
| FDMT4D Molecular Therapeutics, Inc. | 522,823 | $4.9M |
| DSGNDesign Therapeutics, Inc. | 431,840 | $4.6M |
| XOMAXOMA Royalty Corporation | 133,360 | $4.2M |
| TRDAEntrada Therapeutics, Inc. | 324,471 | $4.1M |
| BIOABioAge Labs, Inc. | 214,546 | $3.7M |
| LRMRLarimar Therapeutics, Inc. | 798,462 | $3.6M |
| KROSKeros Therapeutics, Inc. | 321,360 | $3.5M |
| VYGRVoyager Therapeutics, Inc. | 875,568 | $3.4M |
| ALTAltimmune, Inc. | 1,045,926 | $3.2M |
| BDTXBlack Diamond Therapeutics, Inc. | 1,301,664 | $2.8M |
| ADPTAdaptive Biotechnologies Corp | 188,338 | $2.6M |
| AXSMAxsome Therapeutics, Inc. | 15,160 | $2.6M |
| SYRESpyre Therapeutics, Inc. | 47,697 | $2.4M |
| CMPXCompass Therapeutics, Inc. | 439,784 | $2.3M |
| BCAXBicara Therapeutics Inc. | 109,261 | $2.2M |
| NUVLNuvalent, Inc. | 18,893 | $1.9M |
| CATXPerspective Therapeutics, Inc. | 450,097 | $1.9M |
| ABSIAbsci Corporation | 600,445 | $1.8M |
| OPKOPKO HEALTH, INC. | 1,560,000 | $1.8M |
| SMMTSummit Therapeutics Inc. | 88,496 | $1.7M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 19,151 | $1.7M |
| RZLTRezolute, Inc. | 530,229 | $1.6M |
| GMABGenmab A/S | 56,438 | $1.5M |
| IMVTImmunovant, Inc. | 57,086 | $1.4M |
| SGMTSagimet Biosciences Inc. | 271,217 | $1.4M |
| SPRYARS Pharmaceuticals, Inc. | 172,339 | $1.4M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 136,602 | $1.3M |
| CCCCC4 Therapeutics, Inc. | 442,518 | $1.2M |
| ACIUAC Immune SA | 390,165 | $1.1M |
| FATEFATE THERAPEUTICS INC | 883,790 | $1.1M |
| ALDXAldeyra Therapeutics, Inc. | 624,170 | $1.1M |
| RCKTRocket Pharmaceuticals Inc. | 288,264 | $1.0M |
| TENXTENAX THERAPEUTICS, INC. | 62,786 | $1.0M |
| LYELLyell Immunopharma, Inc. | 47,888 | $959K |
| IBRXImmunityBio, Inc. | 110,009 | $844K |
| SANASana Biotechnology, Inc. | 291,268 | $839K |
| HCMHUTCHMED (China) Limited | 55,969 | $837K |
| DNAGinkgo Bioworks Holdings Inc. | 127,048 | $779K |
| UPBUpstream Bio, Inc. | 80,002 | $719K |
| CLYMClimb Bio, Inc. | 104,437 | $715K |
| PLXProtalix BioTherapeutics, Inc. | 296,843 | $644K |
| ZNTLZentalis Pharmaceuticals, Inc. | 272,034 | $634K |
| ALECAlector, Inc. | 283,817 | $610K |
| AVTXAvalo Therapeutics, Inc. | 40,821 | $607K |
| ORMPORAMED PHARMACEUTICALS INC. | 158,209 | $538K |
| ALMSALUMIS INC. | 23,115 | $509K |
| MLTXMoonLake Immunotherapeutics | 26,307 | $490K |
| FLNAFilana Therapeutics Inc. | 239,906 | $405K |
| LENZLENZ Therapeutics, Inc. | 41,874 | $381K |
| NBPNovaBridge Biosciences | 146,322 | $360K |
| TECXTectonic Therapeutic, Inc. | 10,077 | $311K |
| ASRTAssertio Holdings, Inc. | 14,135 | $269K |
| ZURAZura Bio Ltd | 43,135 | $257K |
| NGNENeurogene Inc. | 11,415 | $230K |
| KZRKezar Life Sciences, Inc. | 30,334 | $225K |
| GYREGYRE THERAPEUTICS, INC. | 25,268 | $176K |
| ABEOABEONA THERAPEUTICS INC. | 34,371 | $154K |
| LPCNLipocine Inc. | 19,122 | $153K |
| SVRASavara Inc | 26,421 | $144K |
| CSBRCHAMPIONS ONCOLOGY, INC. | 23,973 | $138K |
| PLRXPLIANT THERAPEUTICS, INC. | 99,773 | $125K |
| PRLDPrelude Therapeutics Inc | 35,210 | $120K |
| AYTUAYTU BIOPHARMA, INC | 43,585 | $119K |
| WHWKWhitehawk Therapeutics, Inc. | 30,090 | $104K |
| RLYBRallybio Corp | 11,280 | $101K |
| AVXLANAVEX LIFE SCIENCES CORP. | 27,238 | $84K |
| ACETAdicet Bio, Inc. | 10,778 | $73K |
| TAOXTAO Synergies Inc. | 12,619 | $72K |
| MNOVMEDICINOVA INC | 50,552 | $69K |
| SPROSpero Therapeutics, Inc. | 29,768 | $69K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 21,678 | $67K |
| CHRSCoherus Oncology, Inc. | 35,397 | $60K |
| CRDFCardiff Oncology, Inc. | 36,650 | $59K |
| LTRNLantern Pharma Inc. | 38,060 | $52K |
| BMEABiomea Fusion, Inc. | 25,339 | $39K |
| ATNMActinium Pharmaceuticals, Inc. | 34,923 | $35K |
| TPSTTempest Therapeutics, Inc. | 11,444 | $19K |
| MGXMetagenomi Therapeutics, Inc. | 12,797 | $17K |
| JSPRJasper Therapeutics Inc. | 18,664 | $16K |
| ABVCABVC BIOPHARMA, INC. | 12,227 | $12K |
| IMMPImmutep Limited | 30,409 | $11K |