| GILDGILEAD SCIENCES, INC. | 409,391 | $57.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 40,152 | $31.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 427,414 | $23.6M |
| SNYSanofi | 434,104 | $20.9M |
| RDYDR REDDYS LABORATORIES LTD | 1,167,182 | $16.2M |
| INSMINSMED Inc | 72,200 | $11.8M |
| EXELEXELIXIS, INC. | 234,142 | $10.0M |
| BBIOBridgeBio Pharma, Inc. | 119,661 | $8.9M |
| PCVXVaxcyte, Inc. | 140,177 | $8.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 24,122 | $8.0M |
| INCYIncyte Corp. | 80,874 | $7.6M |
| CYTKCYTOKINETICS INC | 107,760 | $7.1M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 113,100 | $6.4M |
| FOLDAMICUS THERAPEUTICS, INC. | 428,977 | $6.2M |
| ARGXARGENX SE | 8,239 | $6.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 88,256 | $5.5M |
| PTGXProtagonist Therapeutics, Inc | 47,971 | $5.1M |
| RVMDREVOLUTION MEDICINES, INC. | 49,392 | $4.8M |
| AXSMAxsome Therapeutics, Inc. | 27,735 | $4.7M |
| MRNAModerna, Inc. | 86,909 | $4.4M |
| COGTCogent Biosciences, Inc. | 110,758 | $4.3M |
| NUVLNuvalent, Inc. | 38,420 | $3.9M |
| IONSIONIS PHARMACEUTICALS INC | 52,228 | $3.9M |
| ROIVRoivant Sciences Ltd. | 121,560 | $3.4M |
| GMABGenmab A/S | 118,596 | $3.2M |
| ONCBeOne Medicines Ltd. | 10,158 | $3.0M |
| PTCTPTC THERAPEUTICS, INC. | 42,196 | $2.9M |
| TERNTerns Pharmaceuticals, Inc. | 51,763 | $2.7M |
| TGTXTG THERAPEUTICS, INC. | 63,896 | $2.1M |
| TEVATeva Pharmaceutical Industries Limited | 64,908 | $2.0M |
| INVAInnoviva, Inc. | 79,770 | $1.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 21,085 | $1.8M |
| JAZZJazz Pharmaceuticals plc | 9,199 | $1.7M |
| LGNDLigand Pharmaceuticals Incorporated | 8,505 | $1.7M |
| KURAKura Oncology, Inc. | 201,696 | $1.6M |
| STOKStoke Therapeutics, Inc. | 48,108 | $1.6M |
| LQDALiquidia Corp | 40,031 | $1.5M |
| SRRKScholar Rock Holding Corp | 29,192 | $1.4M |
| DNLIDenali Therapeutics Inc. | 74,069 | $1.4M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 24,263 | $1.3M |
| TVTXTravere Therapeutics, Inc. | 40,812 | $1.2M |
| KALVKalVista Pharmaceuticals, Inc. | 59,986 | $1.2M |
| ADPTAdaptive Biotechnologies Corp | 83,443 | $1.2M |
| APGEApogee Therapeutics, Inc. | 13,631 | $1.1M |
| IMVTImmunovant, Inc. | 45,729 | $1.1M |
| TNGXTango Therapeutics, Inc. | 52,907 | $1.1M |
| OLMAOlema Pharmaceuticals, Inc. | 72,234 | $1.1M |
| VKTXViking Therapeutics, Inc. | 32,677 | $1.1M |
| CLDXCelldex Therapeutics, Inc. | 33,436 | $1.1M |
| ACADACADIA PHARMACEUTICALS INC | 47,485 | $1.1M |
| RLAYRelay Therapeutics, Inc. | 101,349 | $1.0M |
| ANABANAPTYSBIO, INC | 16,836 | $934K |
| IBRXImmunityBio, Inc. | 120,691 | $926K |
| ALMSALUMIS INC. | 41,083 | $905K |
| SIGASIGA TECHNOLOGIES INC | 168,555 | $902K |
| CGEMCullinan Therapeutics, Inc. | 59,974 | $852K |
| ZYMEZymeworks Inc. | 32,394 | $811K |
| HROWHARROW, INC. | 22,273 | $785K |
| SYRESpyre Therapeutics, Inc. | 15,486 | $781K |
| RCKTRocket Pharmaceuticals Inc. | 217,851 | $780K |
| XERSXeris Biopharma Holdings, Inc. | 133,285 | $773K |
| AQSTAquestive Therapeutics, Inc. | 183,188 | $760K |
| RCUSArcus Biosciences, Inc. | 33,445 | $722K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 205,551 | $721K |
| PRTAPROTHENA CORP PUBLIC LTD CO | 72,986 | $709K |
| ARQTArcutis Biotherapeutics, Inc. | 29,651 | $699K |
| DAWNDay One Biopharmaceuticals, Inc. | 31,931 | $685K |
| PGENPRECIGEN, INC. | 175,749 | $680K |
| NTLAIntellia Therapeutics, Inc. | 52,410 | $672K |
| ZNTLZentalis Pharmaceuticals, Inc. | 285,000 | $667K |
| ORKAOruka Therapeutics, Inc. | 12,736 | $625K |
| ARVNARVINAS, INC. | 58,120 | $616K |
| ADMAADMA BIOLOGICS, INC. | 67,933 | $612K |
| KNSAKiniksa Pharmaceuticals International, plc | 12,687 | $611K |
| IRDOpus Genetics, Inc. | 128,366 | $584K |
| CMPXCompass Therapeutics, Inc. | 106,191 | $562K |
| PVLAPALVELLA THERAPEUTICS, INC. | 4,393 | $548K |
| ELVNEnliven Therapeutics, Inc. | 13,672 | $536K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 16,780 | $510K |
| BHVNBiohaven Ltd. | 56,113 | $475K |
| OGNOrganon & Co. | 79,042 | $473K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 13,333 | $451K |
| BIOABioAge Labs, Inc. | 25,321 | $443K |
| NUVBNuvation Bio Inc. | 101,424 | $435K |
| BCAXBicara Therapeutics Inc. | 21,816 | $434K |
| BEAMBeam Therapeutics Inc. | 16,824 | $401K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 4,771 | $400K |
| OCULOCULAR THERAPEUTIX, INC | 46,056 | $390K |
| TECXTectonic Therapeutic, Inc. | 12,446 | $385K |
| APLSApellis Pharmaceuticals, Inc. | 9,521 | $383K |
| PLSEPulse Biosciences Inc Common Stock (DE) | 16,413 | $354K |
| AVXLANAVEX LIFE SCIENCES CORP. | 108,349 | $333K |
| GERNGERON CORP | 220,604 | $329K |
| SVRASavara Inc | 59,829 | $327K |
| KODKodiak Sciences Inc. | 8,415 | $321K |
| CATXPerspective Therapeutics, Inc. | 71,464 | $298K |
| NRIXNurix Therapeutics, Inc. | 19,121 | $296K |
| LRMRLarimar Therapeutics, Inc. | 65,037 | $293K |
| ABSIAbsci Corporation | 97,284 | $292K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 94,208 | $289K |
| TRDAEntrada Therapeutics, Inc. | 22,230 | $281K |
| FDMT4D Molecular Therapeutics, Inc. | 29,160 | $271K |
| ABUSArbutus Biopharma Corp | 60,117 | $271K |
| ARDXARDELYX, INC. | 45,043 | $270K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 8,357 | $268K |
| SMMTSummit Therapeutics Inc. | 13,597 | $258K |
| VRDNViridian Therapeutics, Inc.\DE | 13,101 | $256K |
| ESPREsperion Therapeutics, Inc. | 93,492 | $256K |
| ANNXAnnexon, Inc. | 45,923 | $254K |
| RGNXREGENXBIO Inc. | 30,001 | $251K |
| VCELVericel Corp | 7,778 | $250K |
| SLDBSolid Biosciences Inc. | 34,566 | $249K |
| ZBIOZenas BioPharma, Inc. | 12,658 | $247K |
| IRONDisc Medicine, Inc. | 3,769 | $241K |
| DMACDiaMedica Therapeutics Inc. | 33,599 | $227K |
| FLGTFulgent Genetics Inc. | 14,192 | $226K |
| ORICOric Pharmaceuticals, Inc. | 16,466 | $209K |
| OPKOPKO HEALTH, INC. | 176,985 | $202K |
| KROSKeros Therapeutics, Inc. | 17,807 | $197K |
| SPRYARS Pharmaceuticals, Inc. | 24,273 | $195K |
| MESOMesoblast Limited | 11,800 | $181K |
| SANASana Biotechnology, Inc. | 61,736 | $178K |
| SLSSELLAS Life Sciences Group, Inc. | 40,571 | $172K |
| GRFSGrifols S.A. | 20,554 | $165K |
| CADLCandel Therapeutics, Inc. | 31,398 | $154K |
| ABCLAbCellera Biologics Inc. | 44,051 | $154K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 23,113 | $148K |
| ALTAltimmune, Inc. | 39,229 | $121K |
| RZLTRezolute, Inc. | 39,463 | $120K |
| ZVRAZEVRA THERAPEUTICS, INC. | 11,681 | $109K |
| UPBUpstream Bio, Inc. | 10,850 | $98K |
| ATAIAtai Beckley N.V. | 27,191 | $96K |
| CRDFCardiff Oncology, Inc. | 43,610 | $71K |
| HUMAHumacyte Inc. | 105,119 | $64K |
| FATEFATE THERAPEUTICS INC | 49,425 | $59K |
| XFORX4 Pharmaceuticals, Inc | 13,819 | $57K |
| HURATuHURA Biosciences, Inc./NV | 30,894 | $55K |
| ORGOOrganogenesis Holdings Inc. | 22,355 | $53K |
| CTMXCytomX Therapeutics, Inc. | 10,505 | $49K |
| ALDXAldeyra Therapeutics, Inc. | 28,871 | $49K |
| OCGNOcugen, Inc. | 26,087 | $47K |
| IMUXIMMUNIC, INC. | 35,022 | $39K |
| GALTGALECTIN THERAPEUTICS INC | 10,485 | $29K |
| CHRSCoherus Oncology, Inc. | 14,744 | $25K |
| CGTXCOGNITION THERAPEUTICS INC | 30,204 | $23K |
| MRKRMarker Therapeutics, Inc. | 17,312 | $23K |
| LCTXLineage Cell Therapeutics, Inc. | 13,685 | $22K |
| BMEABiomea Fusion, Inc. | 12,000 | $18K |
| MISTMilestone Pharmaceuticals Inc. | 13,410 | $16K |
| ONCYONCOLYTICS BIOTECH INC | 14,545 | $12K |
| NRSNNeuroSense Therapeutics Ltd. | 11,911 | $9K |
| SGMOQSANGAMO THERAPEUTICS, INC | 14,840 | $4K |