| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 2,817,445 | $155.5M |
| SNYSanofi | 2,223,301 | $107.1M |
| IONSIONIS PHARMACEUTICALS INC | 874,089 | $65.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 836,981 | $52.5M |
| KNSAKiniksa Pharmaceuticals International, plc | 649,629 | $31.3M |
| REGNREGENERON PHARMACEUTICALS, INC. | 32,164 | $24.9M |
| AXSMAxsome Therapeutics, Inc. | 134,792 | $22.8M |
| GILDGILEAD SCIENCES, INC. | 154,780 | $21.6M |
| TERNTerns Pharmaceuticals, Inc. | 384,681 | $20.3M |
| VKTXViking Therapeutics, Inc. | 516,108 | $16.8M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 450,093 | $15.2M |
| TEVATeva Pharmaceutical Industries Limited | 471,891 | $14.2M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 151,842 | $13.2M |
| IMVTImmunovant, Inc. | 503,673 | $12.5M |
| FOLDAMICUS THERAPEUTICS, INC. | 747,465 | $10.8M |
| NTLAIntellia Therapeutics, Inc. | 748,636 | $9.6M |
| ADPTAdaptive Biotechnologies Corp | 649,627 | $9.0M |
| RVMDREVOLUTION MEDICINES, INC. | 91,720 | $8.9M |
| ANABANAPTYSBIO, INC | 158,562 | $8.8M |
| INSMINSMED Inc | 46,230 | $7.6M |
| ELVNEnliven Therapeutics, Inc. | 191,293 | $7.5M |
| TNGXTango Therapeutics, Inc. | 355,229 | $7.4M |
| NKTRNEKTAR THERAPEUTICS | 98,745 | $7.1M |
| ORICOric Pharmaceuticals, Inc. | 522,061 | $6.6M |
| ACADACADIA PHARMACEUTICALS INC | 294,265 | $6.6M |
| KURAKura Oncology, Inc. | 800,597 | $6.5M |
| RCUSArcus Biosciences, Inc. | 281,681 | $6.1M |
| CLDXCelldex Therapeutics, Inc. | 184,104 | $5.8M |
| RDYDR REDDYS LABORATORIES LTD | 382,976 | $5.3M |
| COGTCogent Biosciences, Inc. | 136,450 | $5.3M |
| TVTXTravere Therapeutics, Inc. | 176,390 | $5.2M |
| NUVBNuvation Bio Inc. | 1,207,771 | $5.2M |
| NUVLNuvalent, Inc. | 50,026 | $5.1M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 782,798 | $5.0M |
| FLGTFulgent Genetics Inc. | 302,564 | $4.8M |
| CGEMCullinan Therapeutics, Inc. | 289,115 | $4.1M |
| PTGXProtagonist Therapeutics, Inc | 27,260 | $2.9M |
| KROSKeros Therapeutics, Inc. | 257,884 | $2.8M |
| HRMYHarmony Biosciences Holdings, Inc. | 101,110 | $2.8M |
| CMPXCompass Therapeutics, Inc. | 497,818 | $2.6M |
| JBIOJade Biosciences, Inc. | 169,051 | $2.4M |
| XERSXeris Biopharma Holdings, Inc. | 407,625 | $2.4M |
| BDTXBlack Diamond Therapeutics, Inc. | 1,058,397 | $2.3M |
| TECXTectonic Therapeutic, Inc. | 66,994 | $2.1M |
| ZNTLZentalis Pharmaceuticals, Inc. | 792,001 | $1.9M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 156,551 | $1.5M |
| ARVNARVINAS, INC. | 131,974 | $1.4M |
| ZVRAZEVRA THERAPEUTICS, INC. | 145,222 | $1.4M |
| OLMAOlema Pharmaceuticals, Inc. | 70,711 | $1.1M |
| LGNDLigand Pharmaceuticals Incorporated | 4,943 | $987K |
| APGEApogee Therapeutics, Inc. | 11,481 | $966K |
| ZYMEZymeworks Inc. | 37,919 | $949K |
| CCCCC4 Therapeutics, Inc. | 277,183 | $729K |
| RGNXREGENXBIO Inc. | 85,248 | $714K |
| NRIXNurix Therapeutics, Inc. | 44,976 | $697K |
| SVRASavara Inc | 122,862 | $671K |
| AGENAGENUS INC | 198,502 | $663K |
| PLRXPLIANT THERAPEUTICS, INC. | 517,453 | $652K |
| ASMBASSEMBLY BIOSCIENCES, INC. | 21,761 | $604K |
| OPKOPKO HEALTH, INC. | 522,906 | $596K |
| FATEFATE THERAPEUTICS INC | 469,785 | $564K |
| ANNXAnnexon, Inc. | 92,707 | $514K |
| PLXProtalix BioTherapeutics, Inc. | 207,275 | $450K |
| PRLDPrelude Therapeutics Inc | 109,085 | $373K |
| LENZLENZ Therapeutics, Inc. | 37,314 | $341K |
| ANIPANI PHARMACEUTICALS INC | 4,225 | $325K |
| LRMRLarimar Therapeutics, Inc. | 69,087 | $311K |
| FLNAFilana Therapeutics Inc. | 136,931 | $231K |
| SIGASIGA TECHNOLOGIES INC | 36,064 | $193K |
| ORMPORAMED PHARMACEUTICALS INC. | 50,207 | $171K |
| ABUSArbutus Biopharma Corp | 25,859 | $116K |
| KLRSKalaris Therapeutics, Inc. | 13,655 | $79K |
| AVXLANAVEX LIFE SCIENCES CORP. | 19,655 | $60K |