| ALNYALNYLAM PHARMACEUTICALS, INC. | 169,031 | $55.9M |
| GILDGILEAD SCIENCES, INC. | 318,021 | $44.3M |
| REGNREGENERON PHARMACEUTICALS, INC. | 25,263 | $19.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 207,796 | $11.7M |
| INCYIncyte Corp. | 56,458 | $5.3M |
| MRNAModerna, Inc. | 98,515 | $5.0M |
| LXRXLEXICON PHARMACEUTICALS, INC. | 1,800,000 | $2.8M |
| AXSMAxsome Therapeutics, Inc. | 15,463 | $2.6M |
| OGNOrganon & Co. | 340,721 | $2.0M |
| INSMINSMED Inc | 11,006 | $1.8M |
| RVMDREVOLUTION MEDICINES, INC. | 14,264 | $1.4M |
| PGENPRECIGEN, INC. | 301,988 | $1.2M |
| BBIOBridgeBio Pharma, Inc. | 12,501 | $928K |
| MANEVeradermics Incorporated | 13,100 | $827K |
| PCVXVaxcyte, Inc. | 14,008 | $814K |
| CYTKCYTOKINETICS INC | 10,099 | $666K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 8,673 | $544K |
| TERNTerns Pharmaceuticals, Inc. | 9,820 | $518K |
| ARQTArcutis Biotherapeutics, Inc. | 13,976 | $329K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 5,889 | $323K |
| PTGXProtagonist Therapeutics, Inc | 2,968 | $313K |
| COGTCogent Biosciences, Inc. | 7,199 | $277K |
| PTCTPTC THERAPEUTICS, INC. | 4,001 | $273K |
| ROIVRoivant Sciences Ltd. | 9,521 | $264K |
| EXELEXELIXIS, INC. | 5,945 | $258K |
| NUVLNuvalent, Inc. | 2,518 | $258K |
| TGTXTG THERAPEUTICS, INC. | 7,577 | $252K |
| SLDBSolid Biosciences Inc. | 33,569 | $242K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 2,663 | $232K |
| LGNDLigand Pharmaceuticals Incorporated | 1,133 | $226K |
| FOLDAMICUS THERAPEUTICS, INC. | 14,983 | $217K |
| SRRKScholar Rock Holding Corp | 4,391 | $216K |
| IBRXImmunityBio, Inc. | 25,389 | $194K |
| ADMAADMA BIOLOGICS, INC. | 20,325 | $183K |
| ADPTAdaptive Biotechnologies Corp | 11,370 | $158K |
| OCULOCULAR THERAPEUTIX, INC | 17,507 | $148K |
| SIGASIGA TECHNOLOGIES INC | 23,384 | $125K |
| GERNGERON CORP | 69,505 | $104K |
| INOINOVIO PHARMACEUTICALS, INC. | 50,000 | $87K |
| XERSXeris Biopharma Holdings, Inc. | 14,673 | $85K |
| ARDXARDELYX, INC. | 12,067 | $72K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 23,085 | $71K |
| ABCLAbCellera Biologics Inc. | 20,000 | $70K |
| ANIXAnixa Biosciences Inc | 26,600 | $69K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 16,988 | $60K |
| NUVBNuvation Bio Inc. | 13,146 | $56K |
| ESPREsperion Therapeutics, Inc. | 12,131 | $33K |
| OPKOPKO HEALTH, INC. | 20,721 | $24K |
| ALDXAldeyra Therapeutics, Inc. | 13,237 | $22K |
| NVCTNuvectis Pharma, Inc. | 779 | $6K |