| GILDGILEAD SCIENCES, INC. | 1,771,496 | $246.9M |
| REGNREGENERON PHARMACEUTICALS, INC. | 38,502 | $29.7M |
| EXELEXELIXIS, INC. | 312,296 | $13.4M |
| LGNDLigand Pharmaceuticals Incorporated | 29,900 | $6.0M |
| SNYSanofi | 106,385 | $5.1M |
| INCYIncyte Corp. | 53,555 | $5.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 12,503 | $4.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 61,836 | $3.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 49,487 | $2.8M |
| INSMINSMED Inc | 13,252 | $2.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 40,252 | $2.1M |
| HROWHARROW, INC. | 56,788 | $2.0M |
| AXSMAxsome Therapeutics, Inc. | 11,566 | $2.0M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 18,147 | $1.6M |
| TEVATeva Pharmaceutical Industries Limited | 49,795 | $1.5M |
| JAZZJazz Pharmaceuticals plc | 6,729 | $1.3M |
| RVMDREVOLUTION MEDICINES, INC. | 10,438 | $1.0M |
| VCELVericel Corp | 28,394 | $913K |
| ADMAADMA BIOLOGICS, INC. | 88,032 | $793K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 11,295 | $708K |
| GMABGenmab A/S | 25,515 | $685K |
| VRDNViridian Therapeutics, Inc.\DE | 34,991 | $684K |
| TVTXTravere Therapeutics, Inc. | 21,938 | $652K |
| MRNAModerna, Inc. | 10,654 | $541K |
| ONCBeOne Medicines Ltd. | 1,617 | $480K |
| IBRXImmunityBio, Inc. | 61,592 | $472K |
| PVLAPALVELLA THERAPEUTICS, INC. | 3,557 | $443K |
| ROIVRoivant Sciences Ltd. | 15,908 | $441K |
| ANNXAnnexon, Inc. | 79,173 | $439K |
| VYGRVoyager Therapeutics, Inc. | 104,854 | $405K |
| BBIOBridgeBio Pharma, Inc. | 5,118 | $380K |
| IONSIONIS PHARMACEUTICALS INC | 5,000 | $375K |
| ARGXARGENX SE | 511 | $373K |
| ADPTAdaptive Biotechnologies Corp | 20,900 | $290K |
| NTLAIntellia Therapeutics, Inc. | 22,465 | $288K |
| CYTKCYTOKINETICS INC | 4,364 | $288K |
| PTCTPTC THERAPEUTICS, INC. | 3,734 | $254K |
| KNSAKiniksa Pharmaceuticals International, plc | 5,257 | $253K |
| BHVNBiohaven Ltd. | 29,053 | $246K |
| ARQTArcutis Biotherapeutics, Inc. | 10,290 | $242K |
| TGTXTG THERAPEUTICS, INC. | 7,268 | $241K |
| FOLDAMICUS THERAPEUTICS, INC. | 15,335 | $222K |
| MLTXMoonLake Immunotherapeutics | 11,446 | $213K |
| PTGXProtagonist Therapeutics, Inc | 1,902 | $200K |
| KURAKura Oncology, Inc. | 24,485 | $199K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 55,157 | $194K |
| IRDOpus Genetics, Inc. | 32,000 | $146K |
| ARDXARDELYX, INC. | 24,307 | $145K |
| ANTXAN2 Therapeutics, Inc. | 40,000 | $137K |
| ARMPArmata Pharmaceuticals, Inc. | 13,140 | $135K |
| ABSIAbsci Corporation | 43,112 | $129K |
| OCGNOcugen, Inc. | 70,000 | $127K |
| RGNXREGENXBIO Inc. | 14,268 | $120K |
| NUVBNuvation Bio Inc. | 27,751 | $119K |
| RCKTRocket Pharmaceuticals Inc. | 32,779 | $117K |
| CMPXCompass Therapeutics, Inc. | 21,676 | $115K |
| GRFSGrifols S.A. | 13,685 | $110K |
| OGNOrganon & Co. | 16,669 | $100K |
| AGENAGENUS INC | 29,878 | $100K |
| ALDXAldeyra Therapeutics, Inc. | 52,947 | $89K |
| XERSXeris Biopharma Holdings, Inc. | 14,815 | $86K |
| SIGASIGA TECHNOLOGIES INC | 12,803 | $68K |
| AQSTAquestive Therapeutics, Inc. | 16,000 | $66K |
| SGMOQSANGAMO THERAPEUTICS, INC | 268,755 | $66K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 18,898 | $58K |
| FATEFATE THERAPEUTICS INC | 41,880 | $50K |
| INABIN8BIO, INC. | 33,295 | $49K |
| OPKOPKO HEALTH, INC. | 40,306 | $46K |
| SANASana Biotechnology, Inc. | 15,843 | $46K |
| RZLTRezolute, Inc. | 14,229 | $43K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 47,281 | $38K |
| ESPREsperion Therapeutics, Inc. | 11,705 | $32K |
| CHRSCoherus Oncology, Inc. | 16,994 | $29K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 15,450 | $24K |
| GERNGERON CORP | 15,573 | $23K |
| ALECAlector, Inc. | 10,648 | $23K |
| HUMAHumacyte Inc. | 34,464 | $21K |
| TLSATiziana Life Sciences Ltd | 11,000 | $13K |
| PHIOPhio Pharmaceuticals Corp. | 10,000 | $12K |