| GILDGILEAD SCIENCES, INC. | 4,423,414 | $616.3M |
| REGNREGENERON PHARMACEUTICALS, INC. | 273,120 | $211.0M |
| JAZZJazz Pharmaceuticals plc | 885,201 | $167.3M |
| ARGXARGENX SE | 129,147 | $94.3M |
| INCYIncyte Corp. | 938,848 | $88.5M |
| INSMINSMED Inc | 467,753 | $76.5M |
| IONSIONIS PHARMACEUTICALS INC | 907,533 | $68.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 180,012 | $59.6M |
| VCELVericel Corp | 1,723,572 | $55.4M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,580,840 | $53.5M |
| SRRKScholar Rock Holding Corp | 981,915 | $48.3M |
| ZYMEZymeworks Inc. | 1,908,039 | $47.8M |
| CYTKCYTOKINETICS INC | 714,344 | $47.1M |
| ADPTAdaptive Biotechnologies Corp | 2,688,081 | $37.3M |
| RCUSArcus Biosciences, Inc. | 1,654,754 | $35.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 574,945 | $32.5M |
| PTGXProtagonist Therapeutics, Inc | 306,037 | $32.3M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 957,442 | $30.6M |
| CNTACentessa Pharmaceuticals plc | 702,254 | $27.9M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 459,137 | $25.3M |
| PTCTPTC THERAPEUTICS, INC. | 311,810 | $21.2M |
| EXELEXELIXIS, INC. | 360,201 | $15.4M |
| TEVATeva Pharmaceutical Industries Limited | 391,587 | $11.8M |
| RVMDREVOLUTION MEDICINES, INC. | 106,498 | $10.4M |
| ONCBeOne Medicines Ltd. | 33,728 | $10.0M |
| NUVLNuvalent, Inc. | 81,775 | $8.4M |
| BBIOBridgeBio Pharma, Inc. | 88,130 | $6.5M |
| SVRASavara Inc | 1,052,893 | $5.7M |
| DNLIDenali Therapeutics Inc. | 296,503 | $5.7M |
| ABVXAbivax SA | 49,516 | $5.5M |
| MPLTMapLight Therapeutics, Inc. | 267,746 | $5.4M |
| AUTLAutolus Therapeutics plc | 3,361,156 | $4.6M |
| APGEApogee Therapeutics, Inc. | 54,437 | $4.6M |
| CLDXCelldex Therapeutics, Inc. | 122,404 | $3.9M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 43,872 | $3.8M |
| OCULOCULAR THERAPEUTIX, INC | 441,775 | $3.7M |
| INVAInnoviva, Inc. | 134,239 | $3.1M |
| IMCRImmunocore Holdings plc | 94,936 | $2.9M |
| VRDNViridian Therapeutics, Inc.\DE | 140,260 | $2.7M |
| IRONDisc Medicine, Inc. | 39,910 | $2.6M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 790,971 | $2.4M |
| OGNOrganon & Co. | 336,976 | $2.0M |
| SLNOSOLENO THERAPEUTICS INC | 57,828 | $1.9M |
| MRNAModerna, Inc. | 33,098 | $1.7M |
| ARQTArcutis Biotherapeutics, Inc. | 13,274 | $313K |
| PHVSPharvaris N.V. | 5,724 | $162K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 2,219 | $139K |
| PCVXVaxcyte, Inc. | 2,209 | $128K |
| AXSMAxsome Therapeutics, Inc. | 625 | $106K |
| TGTXTG THERAPEUTICS, INC. | 2,320 | $77K |
| FOLDAMICUS THERAPEUTICS, INC. | 4,729 | $68K |
| LGNDLigand Pharmaceuticals Incorporated | 321 | $64K |
| VKTXViking Therapeutics, Inc. | 1,905 | $62K |
| TERNTerns Pharmaceuticals, Inc. | 1,061 | $56K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 922 | $48K |
| SYRESpyre Therapeutics, Inc. | 888 | $45K |
| APLSApellis Pharmaceuticals, Inc. | 1,100 | $44K |
| IBRXImmunityBio, Inc. | 5,735 | $44K |
| LQDALiquidia Corp | 1,144 | $43K |
| TVTXTravere Therapeutics, Inc. | 1,390 | $41K |
| ACADACADIA PHARMACEUTICALS INC | 1,730 | $39K |
| BEAMBeam Therapeutics Inc. | 1,524 | $36K |
| ADMAADMA BIOLOGICS, INC. | 3,923 | $35K |
| DFTXDefinium Therapeutics Inc. | 1,812 | $34K |
| IMVTImmunovant, Inc. | 1,333 | $33K |
| ELVNEnliven Therapeutics, Inc. | 844 | $33K |
| NKTRNEKTAR THERAPEUTICS | 397 | $29K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 838 | $25K |
| NTLAIntellia Therapeutics, Inc. | 1,973 | $25K |
| DNTHDianthus Therapeutics, Inc. /DE/ | 290 | $24K |
| NRIXNurix Therapeutics, Inc. | 1,535 | $24K |
| ARDXARDELYX, INC. | 3,972 | $24K |
| BHVNBiohaven Ltd. | 2,798 | $24K |
| DAWNDay One Biopharmaceuticals, Inc. | 1,088 | $23K |
| STOKStoke Therapeutics, Inc. | 648 | $21K |
| HROWHARROW, INC. | 553 | $19K |
| KALVKalVista Pharmaceuticals, Inc. | 952 | $19K |
| ANIPANI PHARMACEUTICALS INC | 248 | $19K |
| TNGXTango Therapeutics, Inc. | 904 | $19K |
| KODKodiak Sciences Inc. | 496 | $19K |
| NUVBNuvation Bio Inc. | 4,371 | $19K |
| XERSXeris Biopharma Holdings, Inc. | 3,105 | $18K |
| MLTXMoonLake Immunotherapeutics | 923 | $17K |
| ABUSArbutus Biopharma Corp | 3,766 | $17K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 4,298 | $15K |
| ANABANAPTYSBIO, INC | 257 | $14K |
| ORICOric Pharmaceuticals, Inc. | 1,114 | $14K |
| ANNXAnnexon, Inc. | 2,367 | $13K |
| CGEMCullinan Therapeutics, Inc. | 922 | $13K |
| GERNGERON CORP | 8,599 | $13K |
| FLGTFulgent Genetics Inc. | 803 | $13K |
| ATAIAtai Beckley N.V. | 3,553 | $13K |
| ARVNARVINAS, INC. | 1,077 | $11K |
| KURAKura Oncology, Inc. | 1,326 | $11K |
| OPKOPKO HEALTH, INC. | 9,221 | $11K |
| OLMAOlema Pharmaceuticals, Inc. | 654 | $10K |
| PGENPRECIGEN, INC. | 2,383 | $9K |
| SANASana Biotechnology, Inc. | 2,962 | $9K |
| REVBREVELATION BIOSCIENCES, INC. | 9 | $11 |