| GILDGILEAD SCIENCES, INC. | 3,549,224 | $494.7M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 4,639,799 | $256.1M |
| REGNREGENERON PHARMACEUTICALS, INC. | 85,524 | $66.1M |
| ARGXARGENX SE | 85,333 | $62.3M |
| JAZZJazz Pharmaceuticals plc | 239,265 | $45.2M |
| TEVATeva Pharmaceutical Industries Limited | 879,345 | $26.5M |
| GRFSGrifols S.A. | 2,506,278 | $20.1M |
| ANIPANI PHARMACEUTICALS INC | 230,072 | $17.7M |
| LGNDLigand Pharmaceuticals Incorporated | 86,183 | $17.2M |
| TGTXTG THERAPEUTICS, INC. | 515,328 | $17.1M |
| INCYIncyte Corp. | 171,790 | $16.2M |
| SNYSanofi | 325,758 | $15.7M |
| MRNAModerna, Inc. | 297,803 | $15.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 31,864 | $10.5M |
| INSMINSMED Inc | 62,580 | $10.2M |
| APLSApellis Pharmaceuticals, Inc. | 215,041 | $8.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 63,753 | $3.6M |
| ABUSArbutus Biopharma Corp | 782,763 | $3.5M |
| EXELEXELIXIS, INC. | 72,423 | $3.1M |
| BBIOBridgeBio Pharma, Inc. | 36,171 | $2.7M |
| ONCBeOne Medicines Ltd. | 8,145 | $2.4M |
| RVMDREVOLUTION MEDICINES, INC. | 23,262 | $2.3M |
| SMMTSummit Therapeutics Inc. | 107,959 | $2.0M |
| IONSIONIS PHARMACEUTICALS INC | 26,585 | $2.0M |
| GPCRStructure Therapeutics Inc. | 39,984 | $1.9M |
| IRONDisc Medicine, Inc. | 28,773 | $1.8M |
| COGTCogent Biosciences, Inc. | 38,309 | $1.5M |
| GMABGenmab A/S | 52,688 | $1.4M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 22,128 | $1.4M |
| ROIVRoivant Sciences Ltd. | 43,785 | $1.2M |
| SLNSilence Therapeutics Plc | 202,901 | $1.1M |
| CYTKCYTOKINETICS INC | 14,612 | $963K |
| ANTXAN2 Therapeutics, Inc. | 260,127 | $890K |
| ABCLAbCellera Biologics Inc. | 181,690 | $634K |
| PTGXProtagonist Therapeutics, Inc | 5,757 | $607K |
| PTCTPTC THERAPEUTICS, INC. | 8,295 | $565K |
| ACADACADIA PHARMACEUTICALS INC | 24,193 | $539K |
| RDYDR REDDYS LABORATORIES LTD | 38,727 | $536K |
| ZYMEZymeworks Inc. | 17,468 | $437K |
| CLDXCelldex Therapeutics, Inc. | 12,995 | $412K |
| INVAInnoviva, Inc. | 15,560 | $363K |
| FOLDAMICUS THERAPEUTICS, INC. | 24,933 | $361K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 3,801 | $331K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 6,312 | $326K |
| RCKTRocket Pharmaceuticals Inc. | 78,558 | $281K |
| AQSTAquestive Therapeutics, Inc. | 63,289 | $263K |
| SVRASavara Inc | 43,376 | $237K |
| DFTXDefinium Therapeutics Inc. | 12,136 | $229K |
| OGNOrganon & Co. | 36,820 | $221K |
| ADMAADMA BIOLOGICS, INC. | 16,571 | $149K |
| ADPTAdaptive Biotechnologies Corp | 10,752 | $149K |
| ESPREsperion Therapeutics, Inc. | 51,923 | $142K |
| IBRXImmunityBio, Inc. | 16,914 | $130K |
| DMACDiaMedica Therapeutics Inc. | 18,635 | $126K |
| AVXLANAVEX LIFE SCIENCES CORP. | 40,693 | $125K |
| LXRXLEXICON PHARMACEUTICALS, INC. | 70,000 | $109K |
| HYFTMindWalk Holdings Corp. | 69,947 | $79K |
| ATAIAtai Beckley N.V. | 18,930 | $67K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 21,151 | $65K |
| AGENAGENUS INC | 15,515 | $52K |
| GERNGERON CORP | 29,072 | $43K |
| ONCYONCOLYTICS BIOTECH INC | 44,484 | $38K |