| GILDGILEAD SCIENCES, INC. | 10,539,111 | $1.47B |
| REGNREGENERON PHARMACEUTICALS, INC. | 1,009,798 | $780.2M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 747,544 | $247.3M |
| INSMINSMED Inc | 804,977 | $131.6M |
| INCYIncyte Corp. | 1,003,969 | $94.5M |
| TEVATeva Pharmaceutical Industries Limited | 1,765,686 | $53.2M |
| MRNAModerna, Inc. | 904,823 | $46.0M |
| ARGXARGENX SE | 61,433 | $44.9M |
| ROIVRoivant Sciences Ltd. | 1,480,970 | $41.0M |
| RVMDREVOLUTION MEDICINES, INC. | 138,560 | $13.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 188,536 | $10.7M |
| JAZZJazz Pharmaceuticals plc | 55,640 | $10.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 63,429 | $3.5M |
| HCMHUTCHMED (China) Limited | 232,246 | $3.5M |
| IONSIONIS PHARMACEUTICALS INC | 23,958 | $1.8M |
| IMVTImmunovant, Inc. | 66,848 | $1.7M |
| EXELEXELIXIS, INC. | 34,398 | $1.5M |
| APLSApellis Pharmaceuticals, Inc. | 30,721 | $1.2M |
| CYTKCYTOKINETICS INC | 17,078 | $1.1M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 17,301 | $1.1M |
| BBIOBridgeBio Pharma, Inc. | 12,610 | $936K |
| PHVSPharvaris N.V. | 30,952 | $874K |
| PCVXVaxcyte, Inc. | 12,958 | $753K |
| LGNDLigand Pharmaceuticals Incorporated | 3,555 | $710K |
| FLGTFulgent Genetics Inc. | 41,596 | $661K |
| RDYDR REDDYS LABORATORIES LTD | 45,000 | $623K |
| ACADACADIA PHARMACEUTICALS INC | 26,753 | $596K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 10,763 | $556K |
| SNYSanofi | 10,890 | $525K |
| PROKPROKIDNEY CORP. | 291,708 | $522K |
| INVAInnoviva, Inc. | 21,940 | $511K |
| AXSMAxsome Therapeutics, Inc. | 2,945 | $498K |
| OGNOrganon & Co. | 80,944 | $485K |
| ADMAADMA BIOLOGICS, INC. | 51,761 | $466K |
| TGTXTG THERAPEUTICS, INC. | 13,845 | $460K |
| PTGXProtagonist Therapeutics, Inc | 4,113 | $434K |
| FOLDAMICUS THERAPEUTICS, INC. | 25,627 | $371K |
| DNLIDenali Therapeutics Inc. | 18,604 | $357K |
| ZYMEZymeworks Inc. | 14,084 | $353K |
| ANIPANI PHARMACEUTICALS INC | 4,571 | $352K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 4,017 | $349K |
| HRMYHarmony Biosciences Holdings, Inc. | 12,308 | $345K |
| PTCTPTC THERAPEUTICS, INC. | 4,500 | $307K |
| CLDXCelldex Therapeutics, Inc. | 9,351 | $297K |
| ELVNEnliven Therapeutics, Inc. | 6,936 | $272K |
| DFTXDefinium Therapeutics Inc. | 14,136 | $267K |
| RGCRegencell Bioscience Holdings Ltd | 8,595 | $219K |
| ARQTArcutis Biotherapeutics, Inc. | 9,091 | $214K |
| COGTCogent Biosciences, Inc. | 5,515 | $212K |
| VKTXViking Therapeutics, Inc. | 6,443 | $210K |
| GERNGERON CORP | 132,367 | $197K |
| BHVNBiohaven Ltd. | 19,749 | $167K |
| NUVBNuvation Bio Inc. | 36,072 | $155K |
| ADPTAdaptive Biotechnologies Corp | 10,687 | $148K |
| IBRXImmunityBio, Inc. | 16,526 | $127K |
| ATAIAtai Beckley N.V. | 33,121 | $117K |
| OCULOCULAR THERAPEUTIX, INC | 10,589 | $90K |
| ARDXARDELYX, INC. | 14,282 | $86K |
| ABUSArbutus Biopharma Corp | 11,878 | $53K |