| GILDGILEAD SCIENCES, INC. | 3,094,227 | $431.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 301,196 | $232.7M |
| JAZZJazz Pharmaceuticals plc | 610,297 | $115.4M |
| MRNAModerna, Inc. | 988,908 | $50.2M |
| EXELEXELIXIS, INC. | 954,551 | $40.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 400,020 | $22.6M |
| FOLDAMICUS THERAPEUTICS, INC. | 1,441,683 | $20.8M |
| TEVATeva Pharmaceutical Industries Limited | 568,512 | $17.1M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 47,662 | $15.8M |
| ACADACADIA PHARMACEUTICALS INC | 706,664 | $15.7M |
| INCYIncyte Corp. | 135,105 | $12.7M |
| HCMHUTCHMED (China) Limited | 837,475 | $12.5M |
| INVAInnoviva, Inc. | 519,017 | $12.1M |
| ARGXARGENX SE | 14,401 | $10.5M |
| OGNOrganon & Co. | 1,082,748 | $6.5M |
| ADPTAdaptive Biotechnologies Corp | 379,805 | $5.3M |
| DNAGinkgo Bioworks Holdings Inc. | 700,516 | $4.3M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 55,622 | $3.5M |
| FLGTFulgent Genetics Inc. | 181,922 | $2.9M |
| INSMINSMED Inc | 14,600 | $2.4M |
| ROIVRoivant Sciences Ltd. | 69,253 | $1.9M |
| TERNTerns Pharmaceuticals, Inc. | 31,900 | $1.7M |
| COGTCogent Biosciences, Inc. | 32,600 | $1.3M |
| PTGXProtagonist Therapeutics, Inc | 9,600 | $1.0M |
| RDYDR REDDYS LABORATORIES LTD | 70,595 | $978K |
| IONSIONIS PHARMACEUTICALS INC | 12,601 | $946K |
| RVMDREVOLUTION MEDICINES, INC. | 9,379 | $912K |
| BBIOBridgeBio Pharma, Inc. | 9,800 | $728K |
| VKTXViking Therapeutics, Inc. | 22,187 | $722K |
| NUVLNuvalent, Inc. | 6,700 | $686K |
| AXSMAxsome Therapeutics, Inc. | 4,000 | $676K |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 11,000 | $607K |
| CYTKCYTOKINETICS INC | 8,696 | $573K |
| PTCTPTC THERAPEUTICS, INC. | 7,400 | $504K |
| SRRKScholar Rock Holding Corp | 9,400 | $462K |
| ABVXAbivax SA | 3,800 | $423K |
| SMMTSummit Therapeutics Inc. | 22,200 | $421K |
| GPCRStructure Therapeutics Inc. | 8,600 | $415K |
| PCVXVaxcyte, Inc. | 7,100 | $413K |
| ALMSALUMIS INC. | 18,200 | $401K |
| IBRXImmunityBio, Inc. | 47,400 | $364K |
| ORKAOruka Therapeutics, Inc. | 7,100 | $348K |
| IMVTImmunovant, Inc. | 12,900 | $320K |
| CNTACentessa Pharmaceuticals plc | 6,900 | $274K |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 3,000 | $261K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 6,600 | $211K |
| APGEApogee Therapeutics, Inc. | 2,500 | $210K |
| BEAMBeam Therapeutics Inc. | 8,800 | $210K |
| OCULOCULAR THERAPEUTIX, INC | 15,200 | $129K |
| HYFTMindWalk Holdings Corp. | 35,000 | $40K |