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emavusertib

Generic: CA-4948·Code: CA-4948

emavusertib: developed by 1 company · 7 clinical trials tracked.

emavusertib evidence translation

What we can confirm

7 tracked trials

What it means

Source-backed records connect emavusertib to CRIS; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could emavusertib → CRIS affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence5 indications · 1 study sponsors

Related indications

Chronic Lymphocytic Leukemia; Relapsed Hematologic Malignancy; Acute Myelogenous LeukemiaB-cell MalignanciesChronic Lymphocytic LeukemiaMetastatic Pancreatic Ductal AdenocarcinomaMetastatic Urothelial Carcinoma
Development Pipeline (2)
CompanyPhase
CURIS INC (CRIS)
Chronic Lymphocytic Leukemia; Relapsed Hematologic Malignanc…
Phase 2
CURIS INC (CRIS)
Chronic Lymphocytic Leukemia; Relapsed Hematologic Malignanc…
Phase 1
Clinical Trials (7)

A Phase 2 Study of Emavusertib in Combination With an Approved Bruton Tyrosine Kinase Inhibitor in Patients With Chronic Lymphocytic Leukemia and Other B-cell Malignancies

NCT07271667·Phase 2·CRIS
Recruiting

Primary endpoint: Cohort 1: Undetectable Measurable Residual Disease (uMRD) Rate

Interventionalopen108 targetStarted 2026-04Completion 2027-1111 sites · Italy, Spain, United StatesCuris, Inc.

Phase I Trial of Emavusertib (CA-4948) in Combination With Cisplatin, Gemcitabine, and Durvalumab in Patients With Untreated Advanced or Metastatic Biliary Tract Cancer

NCT07107750·Phase 1
Recruiting

Primary endpoint: To determine the safety of emavusertib in combination with gemcitabine, cisplatin, and durvalumab in patients with BTC as measured by incidences and types of adverse events

Interventionalopen48 targetStarted 2026-03Completion 2032-051 site · United StatesWashington University School of Medicine

Phase I Clinical Trial of CA-4948 (Emavusertib) in Combination With FOLFOX Plus Bevacizumab as Frontline Treatment in Patients With Metastatic Colorectal Cancer

NCT06696768·Phase 1·AMRX
Recruiting

Primary endpoint: Dose limiting toxicities (DLT)

Interventionalopen24 targetStarted 2025-06Completion 2026-1213 sites · United StatesNational Cancer Institute (NCI)

Phase 1 Trial of CA-4948 in Combination With Pembrolizumab to Overcome Resistance to PD-1/PD-L1 Blockade in Metastatic Urothelial Cancer

NCT06439836·Phase 1·AMRX
Recruiting

Primary endpoint: Dose limiting toxicities (DLTs)

Interventionalopen27 targetStarted 2025-05Completion 2027-0611 sites · United StatesNational Cancer Institute (NCI)

A Phase I Clinical Trial of CA-4948 in Combination With Gemcitabine and Nab-Paclitaxel in Metastatic or Unresectable Pancreatic Ductal Carcinoma

NCT05685602·Phase 1·AMRX
Recruiting

Primary endpoint: Dose limiting toxicity rate

Interventionalopen43 targetStarted 2023-06Completion 2026-0426 sites · United StatesNational Cancer Institute (NCI)

A Phase 1/2A, Open Label Dose Escalation and Expansion Study of Orally Administered CA-4948 as a Monotherapy in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

NCT04278768·Phase 1·CRIS
Suspended

Primary endpoint: Determine Maximum Tolerated Dose (MTD) of emavusertib (CA-4948) monotherapy (Phase 1)

Interventionalopen366 targetStarted 2020-07Completion 2026-041 siteCuris, Inc.

An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma

NCT03328078·Phase 1/Phase 2·CRIS
Recruiting

Primary endpoint: Part A: To determine the safety and tolerability of emavusertib as a monotherapy and in combination with ibrutinib: dose-limiting toxicity (DLT)

Interventionalopen152 targetStarted 2017-12Completion 2026-1045 sites · Czechia, France, Israel, Italy…Curis, Inc.

Frequently asked questions

Who is developing emavusertib?

emavusertib is being developed by CURIS INC.

How many clinical trials involve emavusertib?

BioSniper tracks 7 clinical trials involving emavusertib.