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bupivacaine

Generic: BUPIVACAINE HYDROCHLORIDE·Brand: BUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE KIT, BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE, BUPIVACAINE LIPOSOME, EXPAREL, Exparel, MARCAINE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, Marcaine, Marcaine with Epinephrine, Nocita, POSIMIR, Posimir, SENSORCAINE, Sensorcaine, Sensorcaine with Epinephrine, Vivacaine, XARACOLL, Xaracoll, Zynrelef

bupivacaine: sourced relationships with 1 company · 17 clinical trials tracked.

bupivacaine evidence translation

What we can confirm

What it means

Source-backed records connect bupivacaine to PCRX; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could bupivacaine → PCRX affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence6 indications · 0 study sponsors

Related indications

Postsurgical pain management; local analgesia via infiltration in patients aged six years and older and regional analgesia via interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and adductor canal block in adults.Back PainBreast Cancer FemaleHeart DiseasesPain ManagementPostoperative Pain

Study sponsors

No additional listed-company sponsor is linked.

Dated Pipeline Records (1)
CompanyDated record stage
Pacira BioSciences, Inc. (PCRX)
developer · Reported 2024-02-29 · Current development: unknownSource
Postsurgical pain management; local analgesia via infiltrati…
Approved
Clinical Trial Registry Records (17)showing 10 most recent

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canal and iPACK Blocks in Patients Undergoing Primary Total Knee Arthroplasty

NCT07097493Registry updated 2026-08-25·Phase 4
Not yet recruiting

Primary endpoint: Pain Score with Movement

InterventionalRandomizeddouble90 targetStarted 2027-02Completion 2027-061 site · United StatesWake Forest University Health Sciences

Effect of Ultrasound-Guided Preemptive Parasternal Intercostal Nerve Block on the Incidence of Chronic Pain After Cardiac Surgery Via Sternotomy: A Prospective Randomized Controlled Trial

NCT07818512Registry updated 2026-09-30·N/A
Not yet recruiting

Primary endpoint: Incidence of chronic post-sternotomy pain at three months

InterventionalRandomizeddouble132 targetStarted 2026-09Completion 2028-08Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

NCT07430085Registry updated 2026-07-06·Phase 4
Not yet recruiting

Primary endpoint: Amount of opioid medications used (measured in morphine milligrams equivalents)

InterventionalRandomizeddouble150 targetStarted 2026-07Completion 2028-02Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Multimodal Analgesia in Minimally Invasive Cardiac Surgery: A Randomized Controlled Study on the Effectiveness of the Serratus Posterior Superior Intercostal Plane Block

NCT07420712Registry updated 2026-09-11·N/A
Completed

Primary endpoint: Resting NRS pain score at 1 hour postoperatively

InterventionalRandomizedsingle22 enrolledStarted 2026-02Completion 2026-091 site · Turkey (Türkiye)Kartal Kosuyolu High Speciality Training and Research Hospital

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

NCT07212114Registry updated 2026-02-23·Phase 3
Recruiting

Primary endpoint: Magnitude of the analgesic effect

InterventionalRandomizeddouble104 targetStarted 2025-11Completion 2029-081 site · United StatesEmory University

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

NCT07092566Registry updated 2026-07-13·Phase 3
Recruiting

Primary endpoint: Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) pain intensity scores through 7 days (168 hours) for participants receiving Exparel vs. R.E.C.K.

InterventionalRandomizedopen170 targetStarted 2025-11Completion 2027-101 site · United StatesWake Forest University Health Sciences

Preoperative and Postoperative Erector Spinae Plane Block: Effects on Frontal QRS-T Angle in Laparoscopic Surgery - A Prospective Randomized Study

NCT07058194Registry updated 2026-02-27·N/A
Completed

Primary endpoint: Change in Frontal QRS-T Angle Between Preoperative and Postoperative ECG

InterventionalRandomizedopen135 enrolledStarted 2025-07Completion 2025-111 site · Turkey (Türkiye)Harran University

A Randomized Controlled Trial of Bupivacaine With Epinephrine for Local Pain Control Following Perineal Laceration Repair in Patients With Pre-existing Epidural Analgesia: The PAIN Trial

NCT05972681Registry updated 2026-05-27·Phase 4
Terminated

Primary endpoint: Time to First Analgesic

InterventionalRandomizedquadruple3 targetStarted 2025-04Completion 2025-101 site · United StatesMontefiore Medical Center

Opiate-sparing Post-operative Pain Control in Septorhinoplasty: A Prospective Randomized, Double Blind Clinical Trial

NCT06989866Registry updated 2025-10-09·Phase 3
Enrolling by invitation

Primary endpoint: Use of Opiate Pain Medications After Rhinoplasty

InterventionalRandomizedsingle50 targetStarted 2024-12Completion 2026-091 site · United StatesUnited States Naval Medical Center, Portsmouth

Analgesic Requirement for Post-Operative Pain Control in Elective 1-3 Level Transforaminal Lumbar Interbody Fusion: Comparison of Thoracolumbar Interfascial Plane Block With Exparel to Bupivacaine HCl

NCT06350981Registry updated 2026-09-09·Phase 2/Phase 3
Enrolling by invitation

Primary endpoint: Compare efficacy of thoracolumbar interfacial plane block with Exparel vs. standard of care (0.25% Bupivacaine HCL) is surgical subjects undergoing 1-3 level elective transforaminal lumbar interbody fusion.

InterventionalRandomizeddouble76 targetStarted 2024-04Completion 2027-031 site · United StatesFoundation for Orthopaedic Research and Education

Frequently asked questions

Which companies have sourced relationships with bupivacaine?

bupivacaine has dated SEC/FDA relationship records for Pacira BioSciences, Inc..

How many clinical trials involve bupivacaine?

BioSniper tracks 17 clinical trials involving bupivacaine.