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bupivacaine

Generic: BUPIVACAINE HYDROCHLORIDE·Brand: BUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE KIT, BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE, BUPIVACAINE LIPOSOME, EXPAREL, Exparel, MARCAINE, MARCAINE HYDROCHLORIDE, MARCAINE HYDROCHLORIDE PRESERVATIVE FREE, Marcaine, Marcaine with Epinephrine, Nocita, POSIMIR, Posimir, SENSORCAINE, Sensorcaine, Sensorcaine with Epinephrine, Vivacaine, XARACOLL, Xaracoll, Zynrelef

bupivacaine: developed by 1 company · 14 clinical trials tracked.

bupivacaine evidence translation

What we can confirm

What it means

Source-backed records connect bupivacaine to PCRX; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could bupivacaine → PCRX affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence4 indications · 6 study sponsors

Related indications

Postsurgical pain management; local analgesia via infiltration in patients aged six years and older and regional analgesia via interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and adductor canal block in adults.Heart DiseasesPain ManagementPostoperative Pain
Development Pipeline (1)
CompanyPhase
Pacira BioSciences, Inc. (PCRX)
Postsurgical pain management; local analgesia via infiltrati…
Approved
Clinical Trials (14)showing 10 most recent

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canal and iPACK Blocks in Patients Undergoing Primary Total Knee Arthroplasty

NCT07097493·Phase 4
Not yet recruiting

Primary endpoint: Pain Score with Movement

InterventionalRandomizeddouble90 targetStarted 2027-02Completion 2027-061 site · United StatesWake Forest University Health Sciences

Postoperative Pain Outcomes After Use of Bupivacaine-Meloxicam Extended-Release Solution in Robot Assisted Total Knee Arthroplasty: A Prospective Study

NCT07430085·Phase 4·GHRS
Not yet recruiting

Primary endpoint: Amount of opioid medications used (measured in morphine milligrams equivalents)

InterventionalRandomizeddouble150 targetStarted 2026-07Completion 2028-02Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

A Randomized, Double-blind, Active Controlled, Single-center Study to Evaluate the Efficacy of EXPAREL vs. Bupivacaine HCl Administered as Combined Sciatic (in the Popliteal Fossa) and Saphenous (in the Adductor Canal) Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Total Ankle Arthroplasty

NCT07212114·Phase 3
Recruiting

Primary endpoint: Magnitude of the analgesic effect

InterventionalRandomizeddouble104 targetStarted 2025-11Completion 2029-081 site · United StatesEmory University

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

NCT07092566·Phase 3
Recruiting

Primary endpoint: Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) pain intensity scores through 7 days (168 hours) for participants receiving Exparel vs. R.E.C.K.

InterventionalRandomizedopen170 targetStarted 2025-11Completion 2027-101 site · United StatesWake Forest University Health Sciences

Preoperative and Postoperative Erector Spinae Plane Block: Effects on Frontal QRS-T Angle in Laparoscopic Surgery - A Prospective Randomized Study

Completed

Primary endpoint: Change in Frontal QRS-T Angle Between Preoperative and Postoperative ECG

InterventionalRandomizedopen135 enrolledStarted 2025-07Completion 2025-111 site · Turkey (Türkiye)Harran University

A Randomized Controlled Trial of Bupivacaine With Epinephrine for Local Pain Control Following Perineal Laceration Repair in Patients With Pre-existing Epidural Analgesia: The PAIN Trial

NCT05972681·Phase 4
Terminated

Primary endpoint: Time to First Analgesic

InterventionalRandomizedquadruple3 targetStarted 2025-04Completion 2025-101 site · United StatesMontefiore Medical Center

Opiate-sparing Post-operative Pain Control in Septorhinoplasty: A Prospective Randomized, Double Blind Clinical Trial

NCT06989866·Phase 3·UTHR
Enrolling by invitation

Primary endpoint: Use of Opiate Pain Medications After Rhinoplasty

InterventionalRandomizedsingle50 targetStarted 2024-12Completion 2026-091 site · United StatesUnited States Naval Medical Center, Portsmouth

Randomized Control Trial to Assess the Efficacy of Preoperative Erector Spinae Blocks on Cardiac Surgery Postoperative Outcomes

NCT06077422·Phase 2/Phase 3
Enrolling by invitation

Primary endpoint: Postoperative opioid consumption

InterventionalRandomizedquadruple150 targetStarted 2024-01Completion 2027-041 site · United StatesRutgers, The State University of New Jersey

Does Subarachnoid Administration of Hyperbaric Prilocaine Produce an Improved Recovery From Anaesthesia When Compared With Hyperbaric Bupivacaine When Used to Make Cervical Cerclage Easier in Pregnant Women at Risk of Pre-term Loss?

NCT04394533·Phase 4
Completed

Primary endpoint: Time from SAB to Bromage score of I

InterventionalRandomizedquadruple129 enrolledStarted 2021-08Completion 2025-081 site · United KingdomGuy's and St Thomas' NHS Foundation Trust

A Non-Inferiority Randomized Trial Comparing the Impact of Thoracic Epidural Analgesia Versus Surgical Site Infiltration With Liposomal Bupivicaine on the Postoperative Recovery of Patients Following Open Gynecologic Surgery

NCT04117074·Phase 3
Completed

Primary endpoint: Analgesia Assessed by the Area Under the Curve of Visual Analog Scale Pain Intensity Scores

InterventionalRandomizedopen106 enrolledStarted 2021-04Completion 2025-031 site · United StatesSidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Frequently asked questions

Who is developing bupivacaine?

bupivacaine is being developed by Pacira BioSciences, Inc..

How many clinical trials involve bupivacaine?

BioSniper tracks 14 clinical trials involving bupivacaine.