Simplex Trading, Llc

Source: SEC Form 13F · as of Mar 2026

Simplex Trading, Llc holds 275 biotech & pharma companies tracked by BioSniper, totaling $239.8M in value as of Mar 2026 (SEC Form 13F).

Companies held

275

Total value held

$239.8M

CompanySharesValue
UNHUnitedHealth Group Incorporated Common Stock (DE)287,580$77.8M
PFEPFIZER INC1,266,685$35.6M
NVONovo Nordisk A/S392,803$14.4M
MRNAModerna, Inc.219,573$11.2M
ZTSZoetis Inc.74,697$8.8M
APGEApogee Therapeutics, Inc.77,808$6.5M
OSCROscar Health Inc.565,246$6.5M
CAHCardinal Health Inc.25,707$5.4M
ERASErasca, Inc.252,747$4.1M
QUREuniQure N.V.231,769$3.8M
BBIOBridgeBio Pharma, Inc.41,434$3.1M
CORTCORCEPT THERAPEUTICS INC69,515$2.8M
ROIVRoivant Sciences Ltd.88,035$2.4M
DVADaVita Inc.12,475$1.9M
QGENQIAGEN N.V.47,722$1.9M
INSMINSMED Inc10,715$1.8M
MOHMolina Healthcare Inc11,613$1.5M
AZNASTRAZENECA PLC7,753$1.5M
CMPSCOMPASS Pathways plc267,465$1.5M
PBIPROVENTION BIO, INC.130,939$1.4M
DAWNDay One Biopharmaceuticals, Inc.64,464$1.4M
ARGXARGENX SE1,771$1.3M
AGIOAGIOS PHARMACEUTICALS, INC.37,462$1.3M
IMVTImmunovant, Inc.50,276$1.2M
SLSSELLAS Life Sciences Group, Inc.295,162$1.2M
BNTXBioNTech SE14,033$1.2M
CTMXCytomX Therapeutics, Inc.248,438$1.2M
ARDXARDELYX, INC.174,861$1.0M
NBIXNEUROCRINE BIOSCIENCES INC7,144$941K
PRGOPERRIGO Co plc87,608$941K
ARWRARROWHEAD PHARMACEUTICALS, INC.14,281$895K
REPLReplimune Group, Inc.104,875$802K
ACHCAcadia Healthcare Company Inc.33,460$783K
DFTXDefinium Therapeutics Inc.41,156$778K
KODKodiak Sciences Inc.19,755$753K
ABCLAbCellera Biologics Inc.201,236$702K
PTCTPTC THERAPEUTICS, INC.10,180$694K
ABSIAbsci Corporation227,044$681K
PGENPRECIGEN, INC.172,660$668K
WVEWave Life Sciences Ltd.89,263$647K
VRTXVERTEX PHARMACEUTICALS INC / MA1,401$626K
ZBHZimmer Biomet Holdings Inc.6,887$623K
RDYDR REDDYS LABORATORIES LTD44,776$620K
SLNOSOLENO THERAPEUTICS INC18,166$608K
RIOTRiot Platforms, Inc.48,934$605K
PRAXPraxis Precision Medicines, Inc.1,660$535K
CRONCronos Group Inc.212,416$533K
IOVAIOVANCE BIOTHERAPEUTICS, INC.151,831$533K
MLYSMineralys Therapeutics, Inc.19,562$530K
SNDLSNDL Inc.397,934$525K
VTRSViatris Inc38,221$516K
BCRXBIOCRYST PHARMACEUTICALS INC53,965$514K
CRVSCorvus Pharmaceuticals, Inc.34,723$508K
CRBPCorbus Pharmaceuticals Holdings, Inc.52,836$496K
ADMAADMA BIOLOGICS, INC.54,917$495K
SNDXSyndax Pharmaceuticals Inc20,825$486K
FMSFresenius Medical Care AG American Depositary Shares (Each representing 1/2 of an Ordinary Share)21,521$486K
ALKSAlkermes plc.13,138$465K
PRCTPROCEPT BioRobotics Corporation16,725$418K
NKTRNEKTAR THERAPEUTICS5,722$412K
BIIBBIOGEN INC.2,164$397K
OMEROMEROS CORP37,526$396K
KNSAKiniksa Pharmaceuticals International, plc8,002$385K
IRDOpus Genetics, Inc.82,480$375K
MNKDMANNKIND CORP152,471$374K
TEVATeva Pharmaceutical Industries Limited11,315$341K
FULCFulcrum Therapeutics, Inc.41,940$322K
INDVIndivior Pharmaceuticals, Inc.10,533$321K
ABVXAbivax SA2,850$317K
ELVNEnliven Therapeutics, Inc.7,883$309K
RXRXRECURSION PHARMACEUTICALS, INC.97,118$298K
BHVNBiohaven Ltd.34,937$296K
ANIPANI PHARMACEUTICALS INC3,459$266K
CGEMCullinan Therapeutics, Inc.17,631$251K
KROSKeros Therapeutics, Inc.22,288$246K
GLUEMonte Rosa Therapeutics, Inc.14,710$242K
TRVITrevi Therapeutics, Inc.20,277$242K
PROFProfound Medical Corp.36,718$238K
FLNAFilana Therapeutics Inc.139,995$237K
DNLIDenali Therapeutics Inc.12,315$236K
GALTGALECTIN THERAPEUTICS INC84,000$234K
ZNTLZentalis Pharmaceuticals, Inc.98,554$231K
GLPGGalapagos NV7,227$217K
PVLAPALVELLA THERAPEUTICS, INC.1,622$202K
FDMT4D Molecular Therapeutics, Inc.21,660$202K
TGTXTG THERAPEUTICS, INC.6,069$202K
MISTMilestone Pharmaceuticals Inc.149,291$178K
GERNGERON CORP119,000$177K
CATXPerspective Therapeutics, Inc.42,486$177K
ALMSALUMIS INC.8,030$177K
TARSTarsus Pharmaceuticals, Inc.2,465$173K
OLMAOlema Pharmaceuticals, Inc.11,127$166K
CLOVClover Health Investments Corp.93,109$164K
FBIOFortress Biotech Inc.58,329$163K
SMMTSummit Therapeutics Inc.8,410$159K
DNTHDianthus Therapeutics, Inc. /DE/1,875$157K
ICLRICON plc1,366$151K
SUPNSUPERNUS PHARMACEUTICALS, INC.2,850$147K
NUVBNuvation Bio Inc.34,338$147K
ALECAlector, Inc.68,477$147K
AVXLANAVEX LIFE SCIENCES CORP.47,867$147K
URGNUroGen Pharma Ltd.8,066$145K
ARCTArcturus Therapeutics Holdings Inc.18,166$140K
ABEOABEONA THERAPEUTICS INC.31,096$139K
CMPXCompass Therapeutics, Inc.25,851$137K
MBOTMicrobot Medical Inc.54,842$132K
ALLOAllogene Therapeutics, Inc.53,282$130K
NRIXNurix Therapeutics, Inc.8,113$126K
COGTCogent Biosciences, Inc.3,153$121K
ORKAOruka Therapeutics, Inc.2,463$121K
NAGENiagen Bioscience, Inc.26,677$118K
DGXQuest Diagnostics Incorporated596$117K
APLSApellis Pharmaceuticals, Inc.2,735$110K
ZURAZura Bio Ltd18,491$110K
SLDBSolid Biosciences Inc.15,097$109K
RZLTRezolute, Inc.35,127$107K
RGENREPLIGEN CORP903$106K
ALTSALT5 Sigma Corp94,741$105K
NEOGNEOGEN CORP10,767$100K
ESPREsperion Therapeutics, Inc.36,467$100K
RAREUltragenyx Pharmaceutical Inc.4,729$99K
TAKTakeda Pharmaceutical Company Limited American Depositary Shares (each representing 1/2 of a share of Common Stock)5,146$95K
CPRXCATALYST PHARMACEUTICALS, INC.3,811$94K
VYGRVoyager Therapeutics, Inc.22,261$86K
CLPTClearPoint Neuro Inc.8,382$76K
CHRSCoherus Oncology, Inc.44,402$75K
SGMTSagimet Biosciences Inc.13,636$71K
SPROSpero Therapeutics, Inc.30,304$71K
ALTAltimmune, Inc.22,841$70K
TNXPTonix Pharmaceuticals Holding Corp.5,108$70K
ABUSArbutus Biopharma Corp15,574$70K
CRSPCRISPR Therapeutics AG1,407$67K
CADLCandel Therapeutics, Inc.13,216$65K
LENZLENZ Therapeutics, Inc.6,927$63K
IRWDIRONWOOD PHARMACEUTICALS INC17,724$62K
PHVSPharvaris N.V.2,173$61K
PLRXPLIANT THERAPEUTICS, INC.48,054$61K
FBRXForte Biosciences, Inc.2,312$60K
ALHCAlignment Healthcare Inc.3,372$59K
EWTXEdgewise Therapeutics, Inc.1,832$58K
MLTXMoonLake Immunotherapeutics3,075$57K
AURAAura Biosciences, Inc.8,430$56K
KURAKura Oncology, Inc.6,905$56K
NEONeoGenomics Inc.7,536$56K
MDXGMiMedx Group Inc13,856$55K
VTGNVistagen Therapeutics, Inc.89,649$51K
PLXProtalix BioTherapeutics, Inc.22,671$49K
IMTXImmatics N.V.4,891$48K
CAICaris Life Sciences Inc.2,669$48K
IMRXImmuneering Corp8,942$47K
OCULOCULAR THERAPEUTIX, INC5,555$47K
VCELVericel Corp1,456$47K
DNAGinkgo Bioworks Holdings Inc.7,474$46K
BHCBausch Health Companies Inc.8,456$46K
IMCRImmunocore Holdings plc1,451$44K
NKTXNkarta, Inc.20,486$43K
ACRSAclaris Therapeutics, Inc.11,216$42K
TECXTectonic Therapeutic, Inc.1,351$42K
ABOSAcumen Pharmaceuticals, Inc.17,414$41K
BIOABioAge Labs, Inc.2,322$41K
PRQRProQR Therapeutics N.V.24,868$40K
MBXMBX Biosciences, Inc.1,307$39K
IMMXImmix Biopharma, Inc.4,255$39K
UNCYUnicycive Therapeutics, Inc.5,820$38K
ACHAccendra Health Inc.16,576$38K
MAZEMaze Therapeutics, Inc.1,210$36K
TNYATenaya Therapeutics, Inc.50,655$35K
KYTXKyverna Therapeutics, Inc.3,998$35K
AVIRAtea Pharmaceuticals, Inc.6,244$34K
AGLagilon health inc.4,245$34K
ZYMEZymeworks Inc.1,336$33K
ZLABZai Lab Ltd1,735$33K
AUTLAutolus Therapeutics plc23,641$33K
DYNDyne Therapeutics, Inc.1,734$31K
BEAMBeam Therapeutics Inc.1,308$31K
CYPHCYPHERPUNK TECHNOLOGIES INC.39,196$31K
EOLSEvolus, Inc.7,557$31K
MIRMMirum Pharmaceuticals, Inc.303$28K
OTLKOutlook Therapeutics, Inc.132,666$27K
MCRBSeres Therapeutics, Inc.3,070$27K
HOWLWerewolf Therapeutics, Inc.32,526$27K
CRDFCardiff Oncology, Inc.16,454$27K
GANXGain Therapeutics, Inc.13,439$26K
JSPRJasper Therapeutics Inc.29,273$26K
SIGASIGA TECHNOLOGIES INC4,483$24K
LFCRLIFECORE BIOMEDICAL, INC. DE6,277$23K
TARAProtara Therapeutics, Inc.4,449$23K
TWSTTwist Bioscience Corp473$22K
TNGXTango Therapeutics, Inc.1,056$22K
PBHPrestige Consumer Healthcare Inc.355$21K
STIMNeuronetics Inc.14,073$20K
IPSCCentury Therapeutics, Inc.9,028$20K
PGNYProgyny Inc.1,188$20K
NVCTNuvectis Pharma, Inc.2,596$20K
FATEFATE THERAPEUTICS INC16,436$20K
DTILPRECISION BIOSCIENCES INC3,512$19K
ACIUAC Immune SA6,620$18K
SABSSAB BIOTHERAPEUTICS, INC.4,713$18K
ORICOric Pharmaceuticals, Inc.1,348$17K
AARDAardvark Therapeutics, Inc.4,243$16K
LCTXLineage Cell Therapeutics, Inc.9,698$15K
EDITEditas Medicine, Inc.5,981$15K
AKBAAkebia Therapeutics, Inc.10,589$15K
LYELLyell Immunopharma, Inc.693$14K
MGNXMACROGENICS INC4,764$14K
PMCBPharmaCyte Biotech, Inc.19,940$13K
KRYSKrystal Biotech, Inc.50$13K
PRTAPROTHENA CORP PUBLIC LTD CO1,303$13K
PROKPROKIDNEY CORP.6,741$12K
USNAUSANA HEALTH SCIENCES INC687$12K
TECHBIO-TECHNE Corp219$11K
RAPPRapport Therapeutics, Inc.344$11K
ORGOOrganogenesis Holdings Inc.4,495$11K
HRTXHERON THERAPEUTICS, INC. /DE/12,774$10K
PMVPPMV Pharmaceuticals, Inc.8,181$10K
OBIOOrchestra BioMed Holdings Inc.2,381$10K
ANROAlto Neuroscience, Inc.450$10K
LFVNLifevantage Corp2,341$10K
DYAIDYADIC INTERNATIONAL INC12,078$10K
VIVOMERIDIAN BIOSCIENCE INC4,163$10K
ACETAdicet Bio, Inc.1,393$9K
COLLCOLLEGIUM PHARMACEUTICAL, INC259$9K
NRCNational Research Corporation Common Stock (Delaware)498$8K
IDXXIDEXX LABORATORIES INC /DE15$8K
OPKOPKO HEALTH, INC.7,320$8K
OVIDOvid Therapeutics Inc.3,674$8K
VERAVera Therapeutics, Inc.191$8K
HCMHUTCHMED (China) Limited506$8K
RANIRani Therapeutics Holdings, Inc.10,101$7K
CALCCalciMedica, Inc.12,816$7K
NOTVInotiv, Inc.25,074$7K
OCSOculis Holding AG222$6K
ENTAENANTA PHARMACEUTICALS INC455$6K
AMPHAmphastar Pharmaceuticals, Inc.262$5K
OFIXOrthofix Medical Inc. Common Stock (DE)444$5K
SVRASavara Inc926$5K
GYREGYRE THERAPEUTICS, INC.674$5K
STOKStoke Therapeutics, Inc.130$4K
CRNXCrinetics Pharmaceuticals, Inc.108$4K
INMBInmune Bio, Inc.3,366$4K
INNVINNOVUS PHARMACEUTICALS, INC.461$4K
NATRNATURES SUNSHINE PRODUCTS INC146$4K
SLNSilence Therapeutics Plc612$3K
ENLVEnlivex Ltd.2,615$2K
PPBTPURPLE BIOTECH LTD.597$2K
NGNENeurogene Inc.89$2K
ICUIICU Medical Inc.12$2K
STROSUTRO BIOPHARMA, INC.62$2K
BYSIBeyondSpring Inc.864$1K
ORMPORAMED PHARMACEUTICALS INC.374$1K
PCRXPacira BioSciences, Inc.56$1K
COSMCosmos Health Inc.3,803$1K
ADPTAdaptive Biotechnologies Corp86$1K
JBIOJade Biosciences, Inc.83$1K
GHRSGH Research PLC83$1K
ATYRaTYR PHARMA INC1,335$1K
ANIKAnika Therapeutics Inc.70$1K
MXCTMaxCyte Inc.1,267$890
SKINThe Beauty Health Company783$696
LNAILunai Bioworks Inc.1,107$451
OABIOmniAb Inc.283$444
PYXSPyxis Oncology, Inc.253$369
FHTXFoghorn Therapeutics Inc.66$315
TRIBTRINITY BIOTECH PLC555$300
GNLXGENELUX Corp106$256
LNTHLantheus Holdings, Inc.3$227
RFLRafael Holdings, Inc.137$171
PDSBPDS Biotechnology Corp271$163
LTRNLantern Pharma Inc.107$146
NGENNERVGEN PHARMA CORP.27$101
TELATELA Bio Inc.143$88
CELUCelularity Inc.55$73
CLGNCollPlant Biotechnologies Ltd118$63
CASIFCASI Pharmaceuticals, Inc.228$25
RCELAvita Medical Inc.4$14

13F holdings reflect long positions in U.S.-listed securities as reported to the SEC. Values are point-in-time for the most recent reported quarter.

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