| REGNREGENERON PHARMACEUTICALS, INC. | 427,129 | $330.1M |
| GILDGILEAD SCIENCES, INC. | 1,331,058 | $185.7M |
| INSMINSMED Inc | 270,700 | $44.3M |
| IONSIONIS PHARMACEUTICALS INC | 443,272 | $33.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 93,496 | $30.9M |
| TERNTerns Pharmaceuticals, Inc. | 480,740 | $25.3M |
| BBIOBridgeBio Pharma, Inc. | 216,315 | $16.1M |
| PTGXProtagonist Therapeutics, Inc | 141,441 | $14.9M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 203,914 | $12.8M |
| AXSMAxsome Therapeutics, Inc. | 60,759 | $10.3M |
| PTCTPTC THERAPEUTICS, INC. | 121,549 | $8.3M |
| NUVLNuvalent, Inc. | 64,599 | $6.6M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 73,434 | $6.4M |
| PVLAPALVELLA THERAPEUTICS, INC. | 49,103 | $6.1M |
| TVTXTravere Therapeutics, Inc. | 190,762 | $5.7M |
| CYTKCYTOKINETICS INC | 77,093 | $5.1M |
| MRNAModerna, Inc. | 99,545 | $5.1M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 59,076 | $5.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 67,388 | $3.7M |
| DFTXDefinium Therapeutics Inc. | 133,369 | $2.5M |
| SNYSanofi | 50,299 | $2.4M |
| ELVNEnliven Therapeutics, Inc. | 61,632 | $2.4M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 37,469 | $2.1M |
| RVMDREVOLUTION MEDICINES, INC. | 20,118 | $2.0M |
| JAZZJazz Pharmaceuticals plc | 9,284 | $1.8M |
| EXELEXELIXIS, INC. | 40,609 | $1.7M |
| INCYIncyte Corp. | 17,981 | $1.7M |
| ADPTAdaptive Biotechnologies Corp | 110,664 | $1.5M |
| GMABGenmab A/S | 53,962 | $1.4M |
| RDYDR REDDYS LABORATORIES LTD | 94,542 | $1.3M |
| ONCBeOne Medicines Ltd. | 4,404 | $1.3M |
| ROIVRoivant Sciences Ltd. | 44,670 | $1.2M |
| TEVATeva Pharmaceutical Industries Limited | 40,626 | $1.2M |
| ARGXARGENX SE | 1,445 | $1.1M |
| RNAAtrium Therapeutics Inc. | 69,294 | $926K |
| ANIPANI PHARMACEUTICALS INC | 9,035 | $695K |
| TGTXTG THERAPEUTICS, INC. | 11,523 | $383K |
| SRRKScholar Rock Holding Corp | 6,224 | $306K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 5,816 | $301K |
| LGNDLigand Pharmaceuticals Incorporated | 1,462 | $292K |
| PCVXVaxcyte, Inc. | 4,912 | $285K |
| VCELVericel Corp | 8,722 | $281K |
| COGTCogent Biosciences, Inc. | 6,061 | $233K |
| INVAInnoviva, Inc. | 9,876 | $230K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 46,659 | $164K |
| IBRXImmunityBio, Inc. | 16,878 | $129K |
| OGNOrganon & Co. | 19,492 | $117K |
| ADMAADMA BIOLOGICS, INC. | 12,937 | $117K |
| DRTSAlpha Tau Medical Ltd. | 15,000 | $106K |
| XERSXeris Biopharma Holdings, Inc. | 16,725 | $97K |
| CMPXCompass Therapeutics, Inc. | 16,353 | $87K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 26,694 | $82K |
| NUVBNuvation Bio Inc. | 13,994 | $60K |
| ATAIAtai Beckley N.V. | 14,815 | $52K |
| SANASana Biotechnology, Inc. | 14,327 | $41K |
| GERNGERON CORP | 25,381 | $38K |
| ESPREsperion Therapeutics, Inc. | 12,842 | $35K |
| COCPCocrystal Pharma, Inc. | 31,886 | $32K |
| ALECAlector, Inc. | 14,528 | $31K |
| PLXProtalix BioTherapeutics, Inc. | 11,629 | $25K |
| CHRSCoherus Oncology, Inc. | 14,675 | $25K |
| FATEFATE THERAPEUTICS INC | 15,350 | $18K |