| REGNREGENERON PHARMACEUTICALS, INC. | 78,302 | $60.5M |
| INCYIncyte Corp. | 498,835 | $47.0M |
| EXELEXELIXIS, INC. | 579,541 | $24.9M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 401,610 | $22.7M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 22,871 | $7.6M |
| RVMDREVOLUTION MEDICINES, INC. | 36,113 | $3.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 52,017 | $2.9M |
| GILDGILEAD SCIENCES, INC. | 17,747 | $2.5M |
| BHVNBiohaven Ltd. | 278,704 | $2.4M |
| KURAKura Oncology, Inc. | 281,904 | $2.3M |
| KNSAKiniksa Pharmaceuticals International, plc | 42,950 | $2.1M |
| RDYDR REDDYS LABORATORIES LTD | 130,069 | $1.8M |
| ARDXARDELYX, INC. | 295,495 | $1.8M |
| PTCTPTC THERAPEUTICS, INC. | 22,321 | $1.5M |
| AXSMAxsome Therapeutics, Inc. | 8,835 | $1.5M |
| RCKTRocket Pharmaceuticals Inc. | 381,839 | $1.4M |
| TEVATeva Pharmaceutical Industries Limited | 42,533 | $1.3M |
| RGNXREGENXBIO Inc. | 139,639 | $1.2M |
| ANNXAnnexon, Inc. | 195,764 | $1.1M |
| ARGXARGENX SE | 1,448 | $1.1M |
| SNYSanofi | 21,628 | $1.0M |
| NUVBNuvation Bio Inc. | 233,352 | $1.0M |
| INVAInnoviva, Inc. | 31,487 | $734K |
| JAZZJazz Pharmaceuticals plc | 3,788 | $716K |
| DAWNDay One Biopharmaceuticals, Inc. | 31,854 | $683K |
| NTLAIntellia Therapeutics, Inc. | 53,098 | $681K |
| ROIVRoivant Sciences Ltd. | 21,718 | $602K |
| ACADACADIA PHARMACEUTICALS INC | 26,789 | $596K |
| SANASana Biotechnology, Inc. | 187,727 | $541K |
| LRMRLarimar Therapeutics, Inc. | 114,038 | $513K |
| XERSXeris Biopharma Holdings, Inc. | 81,630 | $473K |
| ALDXAldeyra Therapeutics, Inc. | 266,518 | $450K |
| GMABGenmab A/S | 16,747 | $449K |
| CGEMCullinan Therapeutics, Inc. | 27,736 | $394K |
| FATEFATE THERAPEUTICS INC | 324,788 | $390K |
| ABSIAbsci Corporation | 99,022 | $297K |
| ONCBeOne Medicines Ltd. | 814 | $242K |
| AVXLANAVEX LIFE SCIENCES CORP. | 69,101 | $212K |
| CHRSCoherus Oncology, Inc. | 121,967 | $206K |
| TNXPTonix Pharmaceuticals Holding Corp. | 14,358 | $197K |
| IBRXImmunityBio, Inc. | 25,100 | $193K |
| ALXOALX ONCOLOGY HOLDINGS INC | 92,233 | $185K |
| LENZLENZ Therapeutics, Inc. | 18,807 | $172K |
| HUMAHumacyte Inc. | 264,319 | $160K |
| HURATuHURA Biosciences, Inc./NV | 81,316 | $146K |
| KRROKorro Bio, Inc. | 12,777 | $145K |
| DNAGinkgo Bioworks Holdings Inc. | 22,626 | $139K |
| ARVNARVINAS, INC. | 12,417 | $132K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 40,048 | $123K |
| OPKOPKO HEALTH, INC. | 93,222 | $106K |
| OCULOCULAR THERAPEUTIX, INC | 12,532 | $106K |
| ALECAlector, Inc. | 47,080 | $101K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 14,901 | $95K |
| GRFSGrifols S.A. | 11,774 | $94K |
| SIGASIGA TECHNOLOGIES INC | 13,534 | $72K |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 19,204 | $67K |
| AARDAardvark Therapeutics, Inc. | 16,485 | $62K |
| QNCXQuince Therapeutics, Inc. | 600,105 | $61K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 66,966 | $54K |
| JSPRJasper Therapeutics Inc. | 51,428 | $45K |
| ATAIAtai Beckley N.V. | 10,019 | $35K |