| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 34,522,363 | $1.91B |
| SNYSanofi | 11,442,163 | $551.3M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 1,113,568 | $69.8M |
| CYTKCYTOKINETICS INC | 768,264 | $50.6M |
| RCUSArcus Biosciences, Inc. | 2,190,404 | $47.3M |
| DNLIDenali Therapeutics Inc. | 2,436,895 | $46.8M |
| VRDNViridian Therapeutics, Inc.\DE | 1,768,295 | $34.6M |
| CLDXCelldex Therapeutics, Inc. | 1,013,648 | $32.2M |
| BBIOBridgeBio Pharma, Inc. | 351,628 | $26.1M |
| LGNDLigand Pharmaceuticals Incorporated | 127,994 | $25.6M |
| SRRKScholar Rock Holding Corp | 458,017 | $22.5M |
| RVMDREVOLUTION MEDICINES, INC. | 215,947 | $21.0M |
| KNSAKiniksa Pharmaceuticals International, plc | 428,972 | $20.7M |
| PTGXProtagonist Therapeutics, Inc | 173,971 | $18.3M |
| ACADACADIA PHARMACEUTICALS INC | 732,872 | $16.3M |
| IONSIONIS PHARMACEUTICALS INC | 141,544 | $10.6M |
| INCYIncyte Corp. | 112,746 | $10.6M |
| NUVLNuvalent, Inc. | 97,518 | $10.0M |
| CMPXCompass Therapeutics, Inc. | 1,348,259 | $7.1M |
| EXELEXELIXIS, INC. | 164,949 | $7.1M |
| COGTCogent Biosciences, Inc. | 167,412 | $6.4M |
| NRIXNurix Therapeutics, Inc. | 384,831 | $6.0M |
| VCELVericel Corp | 185,337 | $6.0M |
| KURAKura Oncology, Inc. | 675,305 | $5.5M |
| RDYDR REDDYS LABORATORIES LTD | 364,745 | $5.1M |
| OLMAOlema Pharmaceuticals, Inc. | 299,756 | $4.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 5,059 | $3.9M |
| TNGXTango Therapeutics, Inc. | 162,399 | $3.4M |
| ANABANAPTYSBIO, INC | 56,596 | $3.1M |
| PTCTPTC THERAPEUTICS, INC. | 44,558 | $3.0M |
| ZYMEZymeworks Inc. | 101,439 | $2.5M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 35,480 | $2.0M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 6,045 | $2.0M |
| GILDGILEAD SCIENCES, INC. | 11,150 | $1.6M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 12,620 | $1.1M |
| TVTXTravere Therapeutics, Inc. | 33,996 | $1.0M |
| DAWNDay One Biopharmaceuticals, Inc. | 43,698 | $937K |
| STROSUTRO BIOPHARMA, INC. | 35,295 | $879K |
| SLDBSolid Biosciences Inc. | 103,481 | $745K |
| IGCIGC Pharma, Inc. | 43,400 | $11K |