| GILDGILEAD SCIENCES, INC. | 3,129,637 | $436.2M |
| REGNREGENERON PHARMACEUTICALS, INC. | 346,855 | $268.0M |
| INCYIncyte Corp. | 1,500,792 | $141.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 382,701 | $126.6M |
| MRNAModerna, Inc. | 2,392,693 | $121.5M |
| EXELEXELIXIS, INC. | 2,534,992 | $108.7M |
| AXSMAxsome Therapeutics, Inc. | 577,479 | $97.6M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 1,672,491 | $94.5M |
| ARGXARGENX SE | 107,195 | $78.3M |
| ACADACADIA PHARMACEUTICALS INC | 3,343,868 | $74.4M |
| ONCBeOne Medicines Ltd. | 241,426 | $71.7M |
| GMABGenmab A/S | 2,461,342 | $66.0M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 682,850 | $37.7M |
| INSMINSMED Inc | 229,563 | $37.5M |
| SNYSanofi | 767,835 | $37.0M |
| APLSApellis Pharmaceuticals, Inc. | 903,637 | $36.4M |
| IONSIONIS PHARMACEUTICALS INC | 468,363 | $35.2M |
| BBIOBridgeBio Pharma, Inc. | 339,907 | $25.2M |
| OGNOrganon & Co. | 3,227,320 | $19.3M |
| JAZZJazz Pharmaceuticals plc | 91,302 | $17.3M |
| LGNDLigand Pharmaceuticals Incorporated | 80,401 | $16.1M |
| ROIVRoivant Sciences Ltd. | 455,865 | $12.6M |
| LQDALiquidia Corp | 279,475 | $10.5M |
| CYTKCYTOKINETICS INC | 145,890 | $9.6M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 149,148 | $9.4M |
| PTCTPTC THERAPEUTICS, INC. | 136,003 | $9.3M |
| PTGXProtagonist Therapeutics, Inc | 87,858 | $9.3M |
| SYRESpyre Therapeutics, Inc. | 178,389 | $9.0M |
| ARDXARDELYX, INC. | 1,498,798 | $9.0M |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 267,105 | $8.6M |
| ARQTArcutis Biotherapeutics, Inc. | 351,217 | $8.3M |
| RXRXRECURSION PHARMACEUTICALS, INC. | 2,610,726 | $8.0M |
| TVTXTravere Therapeutics, Inc. | 268,549 | $8.0M |
| ADPTAdaptive Biotechnologies Corp | 554,584 | $7.7M |
| ANIPANI PHARMACEUTICALS INC | 99,747 | $7.7M |
| RYTMRHYTHM PHARMACEUTICALS, INC. | 85,506 | $7.4M |
| RVMDREVOLUTION MEDICINES, INC. | 70,970 | $6.9M |
| INVAInnoviva, Inc. | 278,340 | $6.5M |
| VRDNViridian Therapeutics, Inc.\DE | 301,529 | $5.9M |
| HROWHARROW, INC. | 154,096 | $5.4M |
| STOKStoke Therapeutics, Inc. | 163,459 | $5.3M |
| NUVLNuvalent, Inc. | 47,617 | $4.9M |
| VKTXViking Therapeutics, Inc. | 105,570 | $3.4M |
| APGEApogee Therapeutics, Inc. | 40,776 | $3.4M |
| SPRYARS Pharmaceuticals, Inc. | 422,038 | $3.4M |
| ADMAADMA BIOLOGICS, INC. | 360,217 | $3.2M |
| BEAMBeam Therapeutics Inc. | 135,166 | $3.2M |
| CTMXCytomX Therapeutics, Inc. | 568,562 | $2.7M |
| OCULOCULAR THERAPEUTIX, INC | 308,321 | $2.6M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 46,627 | $2.4M |
| CLDXCelldex Therapeutics, Inc. | 68,470 | $2.2M |
| VCELVericel Corp | 53,841 | $1.7M |
| TGTXTG THERAPEUTICS, INC. | 49,947 | $1.7M |
| ALMSALUMIS INC. | 66,099 | $1.5M |
| RDYDR REDDYS LABORATORIES LTD | 91,982 | $1.3M |
| MANEVeradermics Incorporated | 19,775 | $1.2M |
| SIGASIGA TECHNOLOGIES INC | 160,355 | $858K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 123,513 | $789K |
| MAZEMaze Therapeutics, Inc. | 25,485 | $761K |
| OPKOPKO HEALTH, INC. | 500,273 | $570K |
| KNSAKiniksa Pharmaceuticals International, plc | 9,876 | $476K |
| TEVATeva Pharmaceutical Industries Limited | 9,619 | $290K |
| RCUSArcus Biosciences, Inc. | 13,098 | $283K |
| SRRKScholar Rock Holding Corp | 5,324 | $262K |