| GILDGILEAD SCIENCES, INC. | 1,859,012 | $259.1M |
| SNYSanofi | 3,861,894 | $186.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,837,744 | $101.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 109,152 | $84.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 171,797 | $56.8M |
| TEVATeva Pharmaceutical Industries Limited | 1,770,908 | $53.3M |
| INSMINSMED Inc | 299,925 | $49.0M |
| ARGXARGENX SE | 61,418 | $44.9M |
| GMABGenmab A/S | 862,301 | $23.1M |
| ROIVRoivant Sciences Ltd. | 678,518 | $18.8M |
| ONCBeOne Medicines Ltd. | 59,611 | $17.7M |
| JAZZJazz Pharmaceuticals plc | 89,311 | $16.9M |
| EXELEXELIXIS, INC. | 305,465 | $13.1M |
| VCELVericel Corp | 254,252 | $8.2M |
| BBIOBridgeBio Pharma, Inc. | 99,916 | $7.4M |
| IONSIONIS PHARMACEUTICALS INC | 93,382 | $7.0M |
| LGNDLigand Pharmaceuticals Incorporated | 34,576 | $6.9M |
| ABVXAbivax SA | 59,209 | $6.6M |
| INCYIncyte Corp. | 64,764 | $6.1M |
| PCVXVaxcyte, Inc. | 98,155 | $5.7M |
| AXSMAxsome Therapeutics, Inc. | 30,555 | $5.2M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 66,750 | $4.2M |
| ACADACADIA PHARMACEUTICALS INC | 169,954 | $3.8M |
| GRFSGrifols S.A. | 467,028 | $3.7M |
| TGTXTG THERAPEUTICS, INC. | 105,831 | $3.5M |
| DNTHDianthus Therapeutics, Inc. /DE/ | 31,184 | $2.6M |
| COGTCogent Biosciences, Inc. | 62,230 | $2.4M |
| CYTKCYTOKINETICS INC | 34,537 | $2.3M |
| TERNTerns Pharmaceuticals, Inc. | 40,998 | $2.2M |
| VKTXViking Therapeutics, Inc. | 60,110 | $2.0M |
| MRNAModerna, Inc. | 38,290 | $1.9M |
| PTGXProtagonist Therapeutics, Inc | 16,317 | $1.7M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 30,361 | $1.7M |
| IMCRImmunocore Holdings plc | 56,825 | $1.7M |
| NUVLNuvalent, Inc. | 15,810 | $1.6M |
| QUREuniQure N.V. | 96,559 | $1.6M |
| TVTXTravere Therapeutics, Inc. | 48,591 | $1.4M |
| NTLAIntellia Therapeutics, Inc. | 109,290 | $1.4M |
| ORKAOruka Therapeutics, Inc. | 23,667 | $1.2M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 21,998 | $1.1M |
| ADMAADMA BIOLOGICS, INC. | 122,790 | $1.1M |
| ANIPANI PHARMACEUTICALS INC | 14,371 | $1.1M |
| CLDXCelldex Therapeutics, Inc. | 33,053 | $1.0M |
| ZYMEZymeworks Inc. | 40,419 | $1.0M |
| BEAMBeam Therapeutics Inc. | 42,194 | $1.0M |
| DNLIDenali Therapeutics Inc. | 50,900 | $977K |
| SRRKScholar Rock Holding Corp | 19,481 | $958K |
| CAPRCAPRICOR THERAPEUTICS, INC. | 29,316 | $891K |
| ADPTAdaptive Biotechnologies Corp | 61,948 | $860K |
| RVMDREVOLUTION MEDICINES, INC. | 8,820 | $858K |
| NKTRNEKTAR THERAPEUTICS | 10,883 | $783K |
| INVAInnoviva, Inc. | 32,470 | $757K |
| FBRXForte Biosciences, Inc. | 28,697 | $743K |
| RXRXRECURSION PHARMACEUTICALS, INC. | 230,112 | $706K |
| ARQTArcutis Biotherapeutics, Inc. | 28,908 | $681K |
| GPCRStructure Therapeutics Inc. | 11,377 | $548K |
| NAMSNEWAMSTERDAM PHARMA CO N.V. | 15,550 | $498K |
| SVRASavara Inc | 88,720 | $484K |
| BHVNBiohaven Ltd. | 57,065 | $483K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 12,228 | $414K |
| AVXLANAVEX LIFE SCIENCES CORP. | 129,175 | $397K |
| ANABANAPTYSBIO, INC | 5,851 | $324K |
| VRDNViridian Therapeutics, Inc.\DE | 16,519 | $323K |
| HROWHARROW, INC. | 8,496 | $300K |
| AVTXAvalo Therapeutics, Inc. | 19,996 | $299K |
| EVOEvotec SE | 119,409 | $299K |
| APGEApogee Therapeutics, Inc. | 3,498 | $294K |
| CNTACentessa Pharmaceuticals plc | 6,975 | $277K |
| MDWDMediWound Ltd. | 16,539 | $266K |
| FLGTFulgent Genetics Inc. | 16,428 | $261K |
| SLNOSOLENO THERAPEUTICS INC | 7,693 | $258K |
| CHRSCoherus Oncology, Inc. | 152,194 | $257K |
| PVLAPALVELLA THERAPEUTICS, INC. | 1,853 | $231K |
| PTCTPTC THERAPEUTICS, INC. | 3,299 | $225K |
| PGENPRECIGEN, INC. | 49,341 | $191K |
| KURAKura Oncology, Inc. | 22,741 | $185K |
| ABSIAbsci Corporation | 57,284 | $172K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 26,558 | $170K |
| IBRXImmunityBio, Inc. | 18,146 | $139K |
| OGNOrganon & Co. | 13,873 | $83K |
| SIGASIGA TECHNOLOGIES INC | 12,053 | $64K |
| ABEOABEONA THERAPEUTICS INC. | 13,291 | $60K |
| SLSSELLAS Life Sciences Group, Inc. | 10,941 | $46K |
| ABCLAbCellera Biologics Inc. | 12,716 | $44K |
| GERNGERON CORP | 18,188 | $27K |
| HRTXHERON THERAPEUTICS, INC. /DE/ | 13,591 | $11K |