| EXELEXELIXIS, INC. | 3,388,920 | $145.4M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 480,636 | $26.5M |
| SNYSanofi | 509,464 | $24.5M |
| GILDGILEAD SCIENCES, INC. | 136,538 | $19.0M |
| REGNREGENERON PHARMACEUTICALS, INC. | 12,316 | $9.5M |
| ONCBeOne Medicines Ltd. | 29,569 | $8.8M |
| ARGXARGENX SE | 9,275 | $6.8M |
| GMABGenmab A/S | 224,144 | $6.0M |
| INSMINSMED Inc | 34,258 | $5.6M |
| PTGXProtagonist Therapeutics, Inc | 46,442 | $4.9M |
| INVAInnoviva, Inc. | 205,072 | $4.8M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 14,207 | $4.7M |
| INCYIncyte Corp. | 42,597 | $4.0M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 43,972 | $2.3M |
| JAZZJazz Pharmaceuticals plc | 11,366 | $2.1M |
| TEVATeva Pharmaceutical Industries Limited | 63,314 | $1.9M |
| BBIOBridgeBio Pharma, Inc. | 20,790 | $1.5M |
| LGNDLigand Pharmaceuticals Incorporated | 6,570 | $1.3M |
| BMRNBIOMARIN PHARMACEUTICAL INC | 22,875 | $1.3M |
| IMCRImmunocore Holdings plc | 28,387 | $856K |
| TERNTerns Pharmaceuticals, Inc. | 16,157 | $852K |
| COGTCogent Biosciences, Inc. | 18,987 | $731K |
| IONSIONIS PHARMACEUTICALS INC | 9,574 | $719K |
| TVTXTravere Therapeutics, Inc. | 19,636 | $583K |
| RDYDR REDDYS LABORATORIES LTD | 21,145 | $293K |
| QUREuniQure N.V. | 15,909 | $260K |
| CYTKCYTOKINETICS INC | 3,463 | $228K |
| AXSMAxsome Therapeutics, Inc. | 1,182 | $200K |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 2,470 | $155K |
| BHVNBiohaven Ltd. | 17,073 | $144K |
| VKTXViking Therapeutics, Inc. | 3,870 | $126K |
| GPCRStructure Therapeutics Inc. | 2,544 | $123K |
| PCVXVaxcyte, Inc. | 1,879 | $109K |
| DNLIDenali Therapeutics Inc. | 5,199 | $100K |
| ABVXAbivax SA | 886 | $99K |
| ALMSALUMIS INC. | 4,188 | $92K |
| ADPTAdaptive Biotechnologies Corp | 4,421 | $61K |
| AGIOAGIOS PHARMACEUTICALS, INC. | 1,317 | $45K |
| MRNAModerna, Inc. | 801 | $41K |
| ORICOric Pharmaceuticals, Inc. | 3,000 | $38K |
| ARQTArcutis Biotherapeutics, Inc. | 1,517 | $36K |
| BCYCBICYCLE THERAPEUTICS PLC | 4,218 | $20K |
| RVMDREVOLUTION MEDICINES, INC. | 185 | $18K |
| NUVLNuvalent, Inc. | 57 | $6K |
| ROIVRoivant Sciences Ltd. | 197 | $5K |
| ACADACADIA PHARMACEUTICALS INC | 245 | $5K |
| TGTXTG THERAPEUTICS, INC. | 115 | $4K |
| IMVTImmunovant, Inc. | 117 | $3K |
| HCMHUTCHMED (China) Limited | 187 | $3K |
| ANABANAPTYSBIO, INC | 36 | $2K |
| TLXTelix Pharmaceuticals Limited | 153 | $1K |
| FBRXForte Biosciences, Inc. | 46 | $1K |
| ANIPANI PHARMACEUTICALS INC | 11 | $846 |
| IRONDisc Medicine, Inc. | 12 | $767 |
| CLDXCelldex Therapeutics, Inc. | 21 | $666 |
| IOVAIOVANCE BIOTHERAPEUTICS, INC. | 183 | $642 |
| GRFSGrifols S.A. | 75 | $602 |
| GERNGERON CORP | 335 | $499 |
| VCELVericel Corp | 15 | $483 |
| RNAAtrium Therapeutics Inc. | 34 | $455 |
| NTLAIntellia Therapeutics, Inc. | 33 | $423 |
| CTXRCitius Pharmaceuticals, Inc. | 372 | $335 |
| KNSAKiniksa Pharmaceuticals International, plc | 5 | $241 |
| PTCTPTC THERAPEUTICS, INC. | 3 | $204 |
| OGNOrganon & Co. | 22 | $134 |
| PHIOPhio Pharmaceuticals Corp. | 110 | $134 |
| TNXPTonix Pharmaceuticals Holding Corp. | 3 | $41 |
| JBIOJade Biosciences, Inc. | 1 | $14 |
| IBRXImmunityBio, Inc. | 1 | $8 |