| INCYIncyte Corp. | 2,830,799 | $266.4M |
| EXELEXELIXIS, INC. | 4,834,625 | $207.4M |
| GMABGenmab A/S | 4,975,324 | $133.5M |
| REGNREGENERON PHARMACEUTICALS, INC. | 171,571 | $132.6M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 1,621,397 | $89.5M |
| IONSIONIS PHARMACEUTICALS INC | 737,859 | $55.4M |
| INVAInnoviva, Inc. | 1,887,570 | $44.0M |
| ANIPANI PHARMACEUTICALS INC | 564,360 | $43.4M |
| KNSAKiniksa Pharmaceuticals International, plc | 892,666 | $43.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 587,125 | $36.8M |
| ACADACADIA PHARMACEUTICALS INC | 1,569,491 | $34.9M |
| ONCBeOne Medicines Ltd. | 110,586 | $32.8M |
| ADPTAdaptive Biotechnologies Corp | 1,995,202 | $27.7M |
| ANABANAPTYSBIO, INC | 492,120 | $27.3M |
| GRFSGrifols S.A. | 2,723,385 | $21.8M |
| ZYMEZymeworks Inc. | 743,898 | $18.6M |
| NTLAIntellia Therapeutics, Inc. | 1,397,243 | $17.9M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 250,461 | $8.5M |
| SIGASIGA TECHNOLOGIES INC | 1,525,960 | $8.2M |
| PTCTPTC THERAPEUTICS, INC. | 111,632 | $7.6M |
| KROSKeros Therapeutics, Inc. | 590,249 | $6.5M |
| NUVBNuvation Bio Inc. | 1,439,357 | $6.2M |
| SNYSanofi | 84,435 | $4.1M |
| ROIVRoivant Sciences Ltd. | 136,887 | $3.8M |
| PBYIPUMA BIOTECHNOLOGY, INC. | 538,155 | $3.4M |
| LGNDLigand Pharmaceuticals Incorporated | 14,564 | $2.9M |
| BDTXBlack Diamond Therapeutics, Inc. | 834,570 | $1.8M |
| UPBUpstream Bio, Inc. | 185,087 | $1.7M |
| BIOABioAge Labs, Inc. | 87,881 | $1.5M |
| PGENPRECIGEN, INC. | 395,695 | $1.5M |
| RDYDR REDDYS LABORATORIES LTD | 102,643 | $1.4M |
| MLTXMoonLake Immunotherapeutics | 70,140 | $1.3M |
| TEVATeva Pharmaceutical Industries Limited | 38,900 | $1.2M |
| ACIUAC Immune SA | 405,658 | $1.1M |
| ASMBASSEMBLY BIOSCIENCES, INC. | 39,446 | $1.1M |
| XERSXeris Biopharma Holdings, Inc. | 133,760 | $776K |
| VRDNViridian Therapeutics, Inc.\DE | 23,279 | $455K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 7,595 | $393K |
| DAWNDay One Biopharmaceuticals, Inc. | 15,294 | $328K |