| TVTXTravere Therapeutics, Inc. | 4,897,417 | $145.5M |
| PTCTPTC THERAPEUTICS, INC. | 2,074,449 | $141.3M |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 1,895,347 | $98.0M |
| AGIOAGIOS PHARMACEUTICALS, INC. | 2,716,000 | $91.9M |
| IMVTImmunovant, Inc. | 3,564,916 | $88.6M |
| INCYIncyte Corp. | 656,817 | $61.8M |
| CYTKCYTOKINETICS INC | 764,538 | $50.4M |
| NKTRNEKTAR THERAPEUTICS | 578,000 | $41.6M |
| IMCRImmunocore Holdings plc | 1,188,000 | $35.8M |
| IRONDisc Medicine, Inc. | 536,000 | $34.3M |
| KURAKura Oncology, Inc. | 3,736,000 | $30.4M |
| REGNREGENERON PHARMACEUTICALS, INC. | 36,126 | $27.9M |
| KALVKalVista Pharmaceuticals, Inc. | 1,236,000 | $24.9M |
| GRFSGrifols S.A. | 2,988,000 | $24.0M |
| SLDBSolid Biosciences Inc. | 3,200,000 | $23.0M |
| AUTLAutolus Therapeutics plc | 15,800,000 | $21.8M |
| ARVNARVINAS, INC. | 1,978,000 | $21.0M |
| FDMT4D Molecular Therapeutics, Inc. | 2,000,000 | $18.6M |
| SRRKScholar Rock Holding Corp | 336,959 | $16.6M |
| BCYCBICYCLE THERAPEUTICS PLC | 3,398,000 | $15.8M |
| SNYSanofi | 300,000 | $14.5M |
| VYGRVoyager Therapeutics, Inc. | 3,500,000 | $13.5M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 236,000 | $13.0M |
| BBOTBridgeBio Oncology Therapeutics, Inc. | 1,328,000 | $11.9M |
| XERSXeris Biopharma Holdings, Inc. | 1,909,838 | $11.1M |
| ESPREsperion Therapeutics, Inc. | 3,930,125 | $10.8M |
| SGMOQSANGAMO THERAPEUTICS, INC | 40,400,067 | $10.0M |
| ZURAZura Bio Ltd | 1,507,000 | $9.0M |
| TENXTENAX THERAPEUTICS, INC. | 478,827 | $7.7M |
| NUVBNuvation Bio Inc. | 1,736,000 | $7.4M |
| DWTXDogwood Therapeutics, Inc. | 3,280,000 | $6.9M |
| SYRESpyre Therapeutics, Inc. | 120,931 | $6.1M |
| CTORCITIUS ONCOLOGY, INC. | 9,188,855 | $5.7M |
| LCTXLineage Cell Therapeutics, Inc. | 3,182,799 | $5.0M |
| ESLAEstrella Immunopharma Inc. | 4,099,000 | $4.3M |
| NTLAIntellia Therapeutics, Inc. | 336,000 | $4.3M |
| PRTAPROTHENA CORP PUBLIC LTD CO | 439,411 | $4.3M |
| CRBPCorbus Pharmaceuticals Holdings, Inc. | 364,000 | $3.4M |
| KYNBKYNTRA BIO INC. | 400,000 | $2.7M |
| BTAIBioXcel Therapeutics, Inc. | 1,910,076 | $2.6M |
| SCLXSCILEX HOLDING CO | 297,706 | $2.0M |
| IMNNImunon, Inc. | 348,330 | $1.0M |
| OTLKOutlook Therapeutics, Inc. | 4,168,000 | $858K |
| RVPHREVIVA PHARMACEUTICALS HOLDINGS, INC. | 592,079 | $432K |
| REVBREVELATION BIOSCIENCES, INC. | 323,241 | $388K |
| GOVXGeoVax Labs, Inc. | 269,253 | $372K |
| AKTXAkari Therapeutics Plc | 38,922 | $200K |
| PDSBPDS Biotechnology Corp | 173,605 | $105K |