| ARGXARGENX SE | 175,311 | $130.3M |
| ALNYALNYLAM PHARMACEUTICALS, INC. | 281,793 | $92.6M |
| EXELEXELIXIS, INC. | 1,707,715 | $75.2M |
| BBIOBridgeBio Pharma, Inc. | 889,356 | $66.2M |
| TEVATeva Pharmaceutical Industries Limited | 1,664,546 | $50.4M |
| GILDGILEAD SCIENCES, INC. | 357,901 | $50.2M |
| INSMINSMED Inc | 282,734 | $46.6M |
| REGNREGENERON PHARMACEUTICALS, INC. | 52,497 | $40.8M |
| VCELVericel Corp | 678,003 | $22.1M |
| ACADACADIA PHARMACEUTICALS INC | 954,855 | $21.3M |
| INCYIncyte Corp. | 126,176 | $11.9M |
| LGNDLigand Pharmaceuticals Incorporated | 52,652 | $10.5M |
| SNYSanofi | 113,283 | $5.4M |
| HRMYHarmony Biosciences Holdings, Inc. | 176,219 | $4.9M |
| ADMAADMA BIOLOGICS, INC. | 479,579 | $4.4M |
| ROIVRoivant Sciences Ltd. | 142,134 | $4.0M |
| ARWRARROWHEAD PHARMACEUTICALS, INC. | 55,179 | $3.5M |
| PTCTPTC THERAPEUTICS, INC. | 47,871 | $3.3M |
| PTGXProtagonist Therapeutics, Inc | 29,916 | $3.1M |
| GSKGSK plc American Depositary Shares (Each representing two Ordinary Shares) | 22,481 | $1.3M |
| MRNAModerna, Inc. | 22,205 | $1.1M |
| ANIPANI PHARMACEUTICALS INC | 10,257 | $779K |
| KNSAKiniksa Pharmaceuticals International, plc | 15,356 | $739K |
| STOKStoke Therapeutics, Inc. | 20,985 | $683K |
| TGTXTG THERAPEUTICS, INC. | 18,887 | $634K |
| JAZZJazz Pharmaceuticals plc | 3,034 | $571K |
| ARVNARVINAS, INC. | 51,923 | $550K |
| APGEApogee Therapeutics, Inc. | 6,052 | $510K |
| COGTCogent Biosciences, Inc. | 14,280 | $503K |
| CYTKCYTOKINETICS INC | 6,989 | $466K |
| RCUSArcus Biosciences, Inc. | 21,041 | $460K |
| PCVXVaxcyte, Inc. | 6,469 | $378K |
| BEAMBeam Therapeutics Inc. | 14,181 | $343K |
| SUPNSUPERNUS PHARMACEUTICALS, INC. | 6,390 | $329K |
| NUVLNuvalent, Inc. | 2,736 | $289K |
| VYGRVoyager Therapeutics, Inc. | 68,830 | $266K |
| NTLAIntellia Therapeutics, Inc. | 19,240 | $255K |
| GMABGenmab A/S | 9,117 | $247K |
| TRDAEntrada Therapeutics, Inc. | 19,465 | $246K |
| ZYMEZymeworks Inc. | 8,507 | $221K |
| NKTRNEKTAR THERAPEUTICS | 2,898 | $209K |
| NRIXNurix Therapeutics, Inc. | 13,410 | $208K |
| ONCBeOne Medicines Ltd. | 644 | $201K |
| KURAKura Oncology, Inc. | 23,297 | $194K |
| PBYIPUMA BIOTECHNOLOGY, INC. | 17,066 | $109K |
| IBRXImmunityBio, Inc. | 10,189 | $73K |
| OVIDOvid Therapeutics Inc. | 11,262 | $24K |