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olpasiran

olpasiran: developed by 1 company · 3 clinical trials tracked.

olpasiran evidence translation

What we can confirm

What it means

Source-backed records connect olpasiran to ARWR; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could olpasiran → ARWR affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence1 indications · 1 study sponsors

Related indications

Atherosclerotic cardiovascular disease with elevated lipoprotein(a)
Development Pipeline (1)
CompanyPhase
ARROWHEAD PHARMACEUTICALS, INC. (ARWR)
Atherosclerotic cardiovascular disease with elevated lipopro…
Phase 3
Clinical Trials (3)

A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating the Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed by Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)

NCT07293260·Phase 3·AMGN
Recruiting

Primary endpoint: Change in NCP Volume from Baseline to Week 72

InterventionalRandomizeddouble406 targetStarted 2026-03Completion 2028-0640 sites · Australia, Canada, China, Denmark…Amgen

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)

NCT07136012·Phase 3·AMGN
Recruiting

Primary endpoint: Time to CHD Death, Myocardial Infarction, or Urgent Coronary Revascularization, Whichever Occurs First

InterventionalRandomizeddouble11,000 targetStarted 2025-08Completion 2031-1050 sites · United StatesAmgen

A Double-blind, Randomized, Placebo-controlled Phase 2 Study to Evaluate Efficacy, Safety, and Tolerability of Olpasiran (AMG 890) in Subjects With Elevated Lipoprotein(a)

NCT04270760·Phase 2·AMGN
Completed

Primary endpoint: Percentage Change From Baseline in Lipoprotein(a) (Lp[a]) at Week 36

InterventionalRandomizeddouble281 enrolledStarted 2020-07Completion 2022-1136 sites · Australia, Canada, Denmark, Iceland…Amgen

Frequently asked questions

Who is developing olpasiran?

olpasiran is being developed by ARROWHEAD PHARMACEUTICALS, INC..

How many clinical trials involve olpasiran?

BioSniper tracks 3 clinical trials involving olpasiran.