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empagliflozin

Generic: EMPAGLIFLOZIN·Brand: EMPAGLIFLOZIN, Glyxambi, JARDIANCE, Jardiance, Synjardy, Trijardy

empagliflozin: sourced relationships with 1 company · 14 clinical trials tracked.

empagliflozin evidence translation

What we can confirm

14 tracked trials

What it means

Source-backed records connect empagliflozin to LLY; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could empagliflozin → LLY affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence8 indications · 0 study sponsors

Related indications

for the treatment of type 2 diabetes; to reduce the risk of cardiovascular death in adult patients with type 2 diabetes and established cardiovascular disease; to reduce the risk of cardiovascular death and hospitalizations for heart failure in adults; and to reduce the risk of sustained decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, cardiovascular death and hospitalization in adults with chronic kidney disease (CKD) at risk of progression.CardiotoxicityChronic Kidney DiseaseChronic Kidney DiseasesDiabetesDiabetes MellitusDiabetes Mellitus, Type 2Heart Failure

Study sponsors

No additional listed-company sponsor is linked.

Dated Pipeline Records (1)
CompanyDated record stage
ELI LILLY & Co (LLY)
developer · Reported 2025-02-19 · Current development: unknownSource
for the treatment of type 2 diabetes; to reduce the risk of …
Approved
Clinical Trial Registry Records (14)showing 10 most recent

The Effects of SGLT2 Inhibition on Vascular Health and Physical Function in Veterans With CKD

NCT07060417Registry updated 2026-08-20·Phase 2
Not yet recruiting

Primary endpoint: Change in endothelium-dependent vasodilation as measured by flow mediated dilation (FMD)

InterventionalRandomizedquadruple52 targetStarted 2026-10Completion 2029-091 site · United StatesVA Office of Research and Development

The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus

NCT07771010Registry updated 2026-08-18·Phase 4
Recruiting

Primary endpoint: Change in skeletal muscle mitochondrial oxidative capacity

InterventionalRandomizedopen54 targetStarted 2026-04Completion 2028-071 site · SloveniaUniversity Medical Centre Ljubljana

A Randomised, Double-blind, Placebo-controlled Trial With an Open-label Extension to Assess the Pharmacokinetics, Safety, and Efficacy of Empagliflozin Tablets in Paediatric Patients With Chronic Kidney Disease (EMPA-KIDNEY® Kids)

NCT07107945Registry updated 2026-02-18·Phase 3
Recruiting

Primary endpoint: Change from Day 1 to the Week 24 visit in urine albumin-creatinine (UACR) [mg/g]

InterventionalRandomizedquadruple120 targetStarted 2025-12Completion 2029-0650 sites · Argentina, Australia, Belgium, Canada…Boehringer Ingelheim

Repurposing Empagliflozin for Duchenne Muscular Dystrophy - Associated Cardiomyopathy: a Pharmacokinetics, Safety and Proof-of-concept Study Among Children 6-18 Years of Age

NCT06643442Registry updated 2025-08-15·Phase 2
Not yet recruiting

Primary endpoint: Pharmacokinetics - apparent clearance (CL/F)

Interventionalopen12 targetStarted 2025-10Completion 2027-031 site · United KingdomSebastiano Lava

Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease

NCT06430684Registry updated 2026-02-20·Early Phase 1
Recruiting

Primary endpoint: Percentage of participants who complete all study procedures

InterventionalRandomizedopen40 targetStarted 2024-08Completion 2026-071 site · United StatesAnn & Robert H Lurie Children's Hospital of Chicago

Optimization of Albuminuria-Lowering Therapies for Individual Patients With Type 2 Diabetes Using Empagliflozin and Finerenone in a Pilot Remote Clinical Trial.

NCT06094920Registry updated 2026-02-13·Phase 4
Completed

Primary endpoint: Questionnaire results

Interventionalopen12 enrolledStarted 2024-07Completion 2025-091 site · NetherlandsUniversity Medical Center Groningen

Evaluation of the Effectiveness of Empagliflozin in the Prevention of Cardiotoxicity in Cancer Patients Undergoing Chemotherapy Based on Anthracyclines (EMPACT Study).

NCT05271162Registry updated 2026-06-16·Phase 3
Active, not recruiting

Primary endpoint: Number of participants with diagnosis of cancer treatment-related cardiac dysfunction (CTRCD) at any time over the 12-month study period

InterventionalRandomizedquadruple220 targetStarted 2023-09Completion 2028-022 sites · PolandMaria Sklodowska-Curie National Research Institute of Oncology

Effects of Liraglutide, Empagliflozin and Linagliptin on Mild Cognitive Impairment Remission in Type 2 Diabetes (LIGHT-MCI): A Multicentre, Randomised Controlled Trial With An Extension Phase

NCT05313529Registry updated 2026-01-06·N/A
Active, not recruiting

Primary endpoint: Mild cognitive impairment (MCI) remission rate

InterventionalRandomizedopen396 targetStarted 2022-10Completion 2026-075 sites · ChinaThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Empagliflozin in Patients With Acute Heart Failure

NCT05392764Registry updated 2026-02-13·Phase 3
Recruiting

Primary endpoint: A hierarchical composite endpoint consisting of death within 90 days, heart failure rehospitalization within 90 days, WHF during hospitalization, and urine output up to 48 hours after treatment initiation, assessed by the win ratio

InterventionalRandomizedquadruple444 targetStarted 2022-09Completion 2027-1250 sites · JapanJuntendo University

A Placebo-controlled, Proof-of-concept Study to Evaluate the Safety and Efficacy of Lanifibranor Alone and in Combination With the Sodium-glucose Transport Protein 2 (SGLT2) Inhibitor EmpaGliflozin in patiEnts With Non-alcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)

NCT05232071Registry updated 2026-09-09·Phase 2
Completed

Primary endpoint: Absolute Change in HbA1c

InterventionalRandomizedquadruple39 enrolledStarted 2022-06Completion 2024-0642 sites · Belgium, France, Netherlands, United Kingdom…Inventiva Pharma

Frequently asked questions

Which companies have sourced relationships with empagliflozin?

empagliflozin has dated SEC/FDA relationship records for ELI LILLY & Co.

How many clinical trials involve empagliflozin?

BioSniper tracks 14 clinical trials involving empagliflozin.