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bezuclastinib

bezuclastinib: developed by 1 company · 4 clinical trials tracked.

bezuclastinib evidence translation

What we can confirm

What it means

Source-backed records connect bezuclastinib to COGT; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could bezuclastinib → COGT affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence1 indications · 0 study sponsors

Related indications

Advanced Systemic Mastocytosis (AdvSM); SSM; Systemic Mastocytoses, Indolent

Study sponsors

No additional listed-company sponsor is linked.

Development Pipeline (2)
CompanyPhase
Cogent Biosciences, Inc. (COGT)
Advanced Systemic Mastocytosis (AdvSM); SSM; Systemic Mastoc…
Phase 3
Cogent Biosciences, Inc. (COGT)
Advanced Systemic Mastocytosis (AdvSM); SSM; Systemic Mastoc…
Phase 2
Clinical Trials (4)

Intermediate-Size Patient Population Expanded Access to Bezuclastinib for Patients With NonAdvanced Systemic Mastocytosis or Advanced Systemic Mastocytosis

Available
Expanded Access23 sites · United StatesCogent Biosciences, Inc.

Expanded Access to Bezuclastinib to be Coadministered With Sunitinib for Patients With Locally Advanced, Unresectable, or Metastatic Gastrointestinal Stromal Tumors

Available
Expanded Access26 sites · United StatesCogent Biosciences, Inc.

A Multi-Part, Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study of The Safety and Efficacy of CGT9486 in Subjects With Nonadvanced Systemic Mastocytosis

NCT05186753·Phase 2·COGT
Active, not recruiting

Primary endpoint: Part 1: Determine recommended dose of bezuclastinib (CGT9486) in subjects with NonAdvSM

InterventionalRandomizedquadruple237 targetStarted 2022-06Completion 2030-0450 sites · Australia, Belgium, Canada, Czechia…Cogent Biosciences, Inc.

A Phase 2 Open-Label, Multicenter Clinical Study of the Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Profiles of CGT9486 as a Single Agent in Patients With Advanced Systemic Mastocytosis

NCT04996875·Phase 2·COGT
Recruiting

Primary endpoint: Part I: Identify clinically active and tolerable exposures of bezuclastinib in patients with AdvSM

Interventionalopen140 targetStarted 2021-11Completion 2027-0742 sites · Australia, Austria, Belgium, Canada…Cogent Biosciences, Inc.

Frequently asked questions

Who is developing bezuclastinib?

bezuclastinib is being developed by Cogent Biosciences, Inc..

How many clinical trials involve bezuclastinib?

BioSniper tracks 4 clinical trials involving bezuclastinib.