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aleniglipron

Generic: GSBR-1290·Code: GSBR-1290

aleniglipron: developed by 1 company · 4 clinical trials tracked.

aleniglipron evidence translation

What we can confirm

What it means

Source-backed records connect aleniglipron to GPCR; that link alone does not prove the drug works.

What to watch

Watch trial status, endpoints, and the next source-backed update.
BioSniper AIPage evidence connected

Prepared research question

How could aleniglipron → GPCR affect its developer, and what evidence supports the link?

Run cited research

Traceable citations · Unknowns marked

See linked entities and source evidence6 indications · 0 study sponsors

Related indications

Obesity, Overweight, or Chronic Weight ManagementType 2 diabetes mellitus (T2DM) and obesityObesity; Obese; Obesity, Overweight, or Chronic Weight ManagementObesityOverweightWeight Loss

Study sponsors

No additional listed-company sponsor is linked.

Development Pipeline (3)
CompanyPhase
Structure Therapeutics Inc. (GPCR)
Obesity, Overweight, or Chronic Weight Management
Phase 3
Structure Therapeutics Inc. (GPCR)
Type 2 diabetes mellitus (T2DM) and obesity
Phase 2
Structure Therapeutics Inc. (GPCR)
Obesity; Obese; Obesity, Overweight, or Chronic Weight Manag…
Phase 2
Clinical Trials (4)

A Long-Term Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Multiple Maintenance Doses of Oral Once Daily Aleniglipron for Chronic Weight Management in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

NCT07654374·Phase 3·GPCR
Recruiting

Primary endpoint: Percent change in body weight from Baseline

InterventionalRandomizedtriple1,100 targetStarted 2026-07Completion 2028-1150 sites · United StatesGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

A Randomized, Double-Blind, Placebo-Controlled, Pivotal Phase 3 Study to Evaluate the Long-Term Efficacy and Safety of Multiple Maintenance Doses of Once Daily Oral Aleniglipron for Chronic Weight Management in Adults With Obesity or Overweight and a Weight-Related Comorbidity

NCT07654361·Phase 3·GPCR
Recruiting

Primary endpoint: Percent change in body weight from Baseline

InterventionalRandomizedtriple3,600 targetStarted 2026-07Completion 2028-1150 sites · United StatesGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

A Phase 2, Randomized, Double-blind, Placebo-controlled, Study of the Safety and Tolerability of Aleniglipron in Adult Participants With Type 2 Diabetes Mellitus Living With Obesity or Overweight

NCT07400588·Phase 2·GPCR
Recruiting

Primary endpoint: Incidence, severity and relationship of AEs/SAEs

InterventionalRandomizedtriple50 targetStarted 2025-12Completion 2026-1117 sites · United StatesGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of Aleniglipron (GSBR-1290) in Participants Living With Obesity (Body Mass Index ≥ 30 kg/m2) or Overweight (Body Mass Index ≥ 27 kg/m2) With at Least One Weight-related Comorbidity

NCT06693843·Phase 2·GPCR
Completed

Primary endpoint: Percent change in body weight from Baseline to Week 36

InterventionalRandomizedtriple230 enrolledStarted 2024-10Completion 2026-0739 sites · United StatesGasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Frequently asked questions

Who is developing aleniglipron?

aleniglipron is being developed by Structure Therapeutics Inc..

How many clinical trials involve aleniglipron?

BioSniper tracks 4 clinical trials involving aleniglipron.